Maya Hoptman

Sean Agbor-Enoh, MD, PhD – video clip

Posted on by Maya Hoptman

Dr. Nana-Sinkam interviewed lung transplantation researcher and 2023 ASCI inductee Sean Agbor-Enoh, MD, PhD (view profile). Dr. Agbor-Enoh is Laboratory Chief, NIH Lasker Clinical Tenure Track Investigator, and NIH Distinguished Scholar, Laboratory of Applied Precision Omics (APO) Division of Intramural Research, NHLBI-NIH; Lead Investigator and Director, Genomic Research Alliance for Transplantation; and Adjunct Associate Professor of Medicine, Lung Transplant Program, Johns Hopkins Hospital. His team has developed cell-free DNA (cfDNA) approaches that reliably detect transplant rejection at an earlier stage than biopsy. Dr. Agbor-Enoh relates the influences of his early background on his current work, surprises and discoveries in his research on lung transplantation, and how these findings can be applied for other medical conditions — while offering advice and encouragement to young physician-scientists and colleagues. — Posted March 2023

Recipient of the 2023 Marian W. Ropes, MD, Award: Wendy S. Garrett, MD, PhD

Posted on by Maya Hoptman
Wendy S. Garrett, MD, PhD
Dr. Garrett

The American Society for Clinical Investigation is pleased to recognize Wendy S. Garrett, MD, PhD, as the recipient of the inaugural ASCI/Marian W. Ropes, MD, Award, for her scientific contributions to the understanding of diseases related to perturbations in the balance between the immune system and microbiome. Dr. Garrett, who will be recognized at the 2023 AAP/ASCI/APSA Joint Meeting, receives an honorarium of $10,000, and delivers a scientific talk at the 2024 meeting.

Dr. Garrett’s work has provided insight into how gut microbes instigate and propagate inflammation, and how host and microbial factors work in concert to exacerbate inflammatory bowel disease (IBD). Her laboratory discovered that intestinal tuft cells orchestrate antiparasite immunity, with taste receptors playing key roles. Dr. Garrett established that oral microbes promote the development of colorectal cancer. Her work on short-chain fatty acids and regulatory T cells identified a diet-derived microbial metabolite that regulates a lymphocyte population of critical importance for human health. Dr. Garrett’s study of chronic kidney disease in patients with colon cancer spurred preclinical studies indicating that changes in dietary amino acid consumption can have a marked effect on microbial enzyme activities.

Dr. Garrett founded the Harvard Chan Microbiome in Public Health Center and co-leads a Cancer Research UK Grand Challenges Award — including more than 100 North American and European researchers — to study colon cancer and the gut microbiome. As associate director of the immunology graduate program at Harvard Medical School, she has taken on leadership roles for diversity, equity, inclusion, and belonging — as a mentor for women and postdoctoral fellows underrepresented in biomedical sciences.

I am enormously grateful to my mentors and to trailblazers like Dr. Ropes who made my career path possible, inspire me to emulate their scientific rigor, clinic acumen, and their outstanding mentorship and to pay it forward.

— Dr. Garrett

She was nominated for this recognition by Dr. Laurie H. Glimcher, who wrote, “The breadth and depth of her lab’s works is phenomenal, and she has made many fundamental contributions to the fields of microbiology and immunology of import for inflammatory bowel diseases, cancer, immunity against parasitic infections, and chronic kidney disease.”

Dr. Garrett received her BS, MS, MD, and PhD from Yale University. She completed her clinical residency at Brigham and Women’s Hospital and fellowship at Harvard Medical School and the Dana-Farber Cancer Institute; her research fellowship was at the Harvard T.H. Chan School of Public Health (HSPH). She is Irene Heinz Given Professor of Immunology and Infectious Diseases at HSPH and professor of medicine at Harvard Medical School. Dr. Garrett was elected to the ASCI in 2020.

 

Recipient of the 2023 Louis W. Sullivan, MD, Award: Duane A. Mitchell, MD, PhD

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Duane A. Mitchell
Dr. Mitchell

Dr. Mitchell’s research focuses on the development of immunotherapy treatments for adults and children with malignant brain tumors. In studying glioblastoma, an aggressive and therapy-resistant aggressive type of cancer, his laboratory found that preconditioning the vaccine site with a potent recall antigen such as tetanus/diphtheria toxoid significantly improved lymph node homing and efficacy of tumor antigen–specific dendritic cells in both patients and a mouse model. His team discovered that certain hematopoietic stem cells could overcome complete resistance to PD-1 checkpoint blockade treatment through mechanisms that alter the tumor microenvironment in glioblastoma. In evaluation of personalized adoptive cellular therapy for refractory pediatric medulloblastoma, Dr. Mitchell demonstrated the safety and profound clonal T cell expansion of tumor-reactive lymphocytes; tumor-reactive T cells persisted in circulation for months after treatment in preclinical models and in children with relapsed medulloblastoma. Dr. Mitchell’s many discoveries have formed the basis of FDA-approved investigational new drug applications and first-in-human phase I and phase II clinical trials.

My sincerest hope is that through my research I can contribute to the body of knowledge that ultimately leads to more effective treatments for cancer, that through my mentorship I can turn my mistakes into others’ wisdom to be applied toward even greater goals, and that through my example, I can inspire the minds of other young people, particularly young black men, to pursue the remarkable journey and rewarding life of the physician-scientist.

— Dr. Mitchell
Drs. Licht, Mitchell, and Sullivan (seated) with DEIC member Dr. Dineo Khabele and  Co-Chair Dr Sherita H. Golden (standing) at the Sullivan Award Presentation, Joint Meeting, April 22, 2023

Dr. Jonathan D. Licht nominated Dr. Mitchell for the Award in recognition of his “pioneering work, outstanding leadership, and dedicated service … In addition to being an accomplished scientist and excellent mentor, Dr. Mitchell is an impactful leader at our institution and on the national stage.”

Dr. Mitchell received his BA from Rutgers College and his MD and PhD from Duke University, where he also completed his residency and postdoctoral work. Along with his role as director of the University of Florida Clinical and Translational Science Institute, he is Assistant Vice President for Research; Associate Dean for Clinical and Translational Sciences in the College of Medicine codirector of the Preston A. Wells, Jr., Center for Brain Tumor Therapy at UF Health; and Phyllis Kottler Friedman Professor in the Lillian S. Wells Department of Neurosurgery. Dr. Mitchell was elected to the ASCI in 2020.

 

Charles S. Dela Cruz, MD, PhD—video clip

Posted on by Maya Hoptman

Dr. Nana-Sinkam interviewed 2022 ASCI inductee Charles S. Dela Cruz, MD, PhD (view profile) at the end of the year. Dr. Dela Cruz is Associate Professor of Medicine (Pulmonary Critical Care and Sleep Medicine) and Microbial Pathogenesis; Director, Center for Pulmonary Infection Research and Treatment (CPIRT); Vice Chief, Clinical and Basic Research; and Director, Physician Scientist Training Program in the Department of Internal Medicine at Yale School of Medicine. His laboratory studies the role of respiratory infection in the pathogenesis of acute and chronic lung diseases, specifically how lung infection/pneumonia contribute to inflammation, injury, and tissue repair in the lung. Dr. Dela Cruz discusses his history as a researcher and clinician, offers advice about finding a niche in both areas, and reflects on how the experience with COVID is influencing how the physician-scientist works. — Posted December 2022

Valerie A. Arboleda, MD, PhD—video clip

Posted on by Maya Hoptman

Our second Perspectives video features Dr. Nana-Sinkam’s interview with 2022 ASCI inductee Valerie A. Arboleda, MD, PhD (view profile), Assistant Professor of Pathology, Laboratory Medicine, and Human Genetics at the University of California, Los Angeles. Dr. Arboleda’s research focuses on the application of next-generation sequencing to understand the basis of genetic syndromes. She talks about her scientific background; her contribution to developing an FDA-approved scalable COVID-19 test; and the need to improve equity in genetic testing.

Diversity, Equity, and Inclusion update — July 2022

Posted on by Maya Hoptman

The Diversity, Equity, and Inclusion Committee is pleased to announce a new video series, ASCI Perspectives.

Deleted:
Consuelo H. Wilkins, MD, MSCI
Consuelo Wilkins
S. Patrick Nana-Sinkam, MD
Patrick Nana-Sinkam

Led by Committee Member Patrick Nana-Sinkam, MD (Virginia Commonwealth University; elected 2019), the interviews are a forum to highlight physician-scientists in the ASCI community who are members of populations underrepresented in medicine or science (UiMS). We invite you to watch for first-person insights into the guest’s career path, scientific work, and mentoring and collaborative relationships.

We are proud to initiate the series with new ASCI member Consuelo H. Wilkins, MD, MSCI (view profile), who is Chief Equity Officer and Senior Associate Dean for Health Equity and Inclusive Excellence; Associate Director of the Vanderbilt Institute for Translational Science; and Professor of Medicine, Division of Geriatric Medicine, Vanderbilt University. Dr. Wilkins, a leading health equity researcher, discusses the origins of her research path and shares lessons learned.

 

View the video: full interview (15.5 min); shorter clip (4.5 min).
Click here to read the transcript.

 

 

ASCI Resources

 

Consuelo H. Wilkins, MD, MSCI—video clip

Posted on by Maya Hoptman

The DEIC is proud to initiate the ASCI Perspectives series with DEIC Member Dr. Patrick Nana-Sinkam’s (elected 2019; view profile) interview with Consuelo H. Wilkins, MD, MSCI (elected 2022; view profile). Dr. Wilkins is Chief Equity Officer and Senior Associate Dean for Health Equity and Inclusive Excellence; Associate Director of the Vanderbilt Institute for Translational Science; and Professor of Medicine, Division of Geriatric Medicine, Vanderbilt University. She was elected to the National Academy of Medicine in 2020. In the interview, Dr. Wilkins, a leading health equity researcher, discusses the origins of her research path and shares lessons learned.

Diversity, Equity, and Inclusion update – March 2021

Posted on by Maya Hoptman

Message from the Chair

March 2021

DEIC Chair Sophie Paczesny
Dr. Paczesny

I am pleased to share with you the the accomplishments of the Diversity, Equity, and Inclusion Committee (DEIC) since it was established in 2020. The ASCI bylaws state that the DEIC “ensures that the organization, its programs, and its mentoring mechanisms promote and recognize diversity, inclusion, and equity.” With these goals in mind, the Committee has developed two foundational documents.

The first intended to establish a common understanding of key terms. This Definitions document outlines the considerations underlying diversity, equity, and inclusion, as well as presenting the term “underrepresented in medicine and science (UiMS)” in reference to populations that are underrepresented relative to their numbers in the general US population.

The second is a mechanism to collect detailed demographic information, which was initiated with the 2022 member nomination process and will be applied in all areas of the Society. We ask that members provide demographic details through their ASCI account. The data will allow us to determine the current makeup of the Society’s populations, areas needing attention, and changes over time. Information will be kept confidential, and data deidentified for any reporting.

I look forward to bringing you news of further steps the Committee and the ASCI undertake in the areas of diversity, equity, and inclusion, and invite you to return to this page for periodic updates and additional resources.

Sincerely, on behalf of the Committee,

Sophie Paczesny, MD, PhD
Chair, Diversity, Equity, and Inclusion Committee

Past messages of note

  • June 2020 – From the ASCI President. In view of the events of 2020 that brought US systemic racism and inequality into sharp focus, President Lorraine Ware described in a message to the membership a plan to establish a Diversity, Inclusion, and Equity Committee in the ASCI bylaws. The Committee’s would aim to ensure that all ASCI programs emphasize diversity, inclusion, and equity; establish mentoring opportunities for underrepresented physician-scientists; and consider how the ASCI can better recognize and promote health equity research.
  • August 2020 – JCI Viewpoint. The leadership of the Society, the Journal of Clinical Investigation, and JCI Insight expanded on the Statement with a publication in the JCI, providing greater detail  – including planned evaluation of the current status of diversity, inclusion, and equity — as well as historical and present-day context for the ASCI and its publications.

Resources

ASCI pages and posts

Publications in the JCI Family of Journals

JCI Viewpoints
JCI Editorial
Presidential addresses
JCI Insight Perspectives

JCI Editor’s update, January 2021

Posted on by Maya Hoptman

Dear Colleague,

As the year 2021 begins, I would like to take the opportunity to update you on recent JCI activity. The Journal continues to build on its history of publishing outstanding biomedical research that garners wide attention (highlighted below my signature).

The COVID-19 pandemic affected the JCI’s operations in many ways:

  • Due to the pandemic’s disruption of research activities, the editorial board instituted new policies to streamline the review and decision processes, and to allow authors enough time to complete additional experiments requested by reviewers (see the related editorial).
  • The number of research submissions increased by almost 25% in 2020 compared with 2019.
  • Among a total of 424 research articles, the JCI published 19 on COVID-19.

In the Clinical Medicine (CMED) category, now in its eighth year, the JCI continues to welcome submissions reporting diagnostic advances, new medical therapies and interventions, and observational studies that have the potential to improve medical practice and health outcomes. In 2020, the JCI published 57 CMED articles, including:

JCI Viewpoint articles have showcased experts and thought leaders in medicine, academia, nonprofit organizations, and industry, and representatives of the JCI and the ASCI on subjects of topical and long-term interest to scientists and society at large. In January, the Journal published a series of Viewpoints on the effects of climate change on human health. A July Viewpoint, Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists, attracted nearly 16,000 views. Other Viewpoint articles have dealt with COVID-19; translational medicine; the effects of vaping; marijuana use in pregnancy; alternative medicine; and racism, diversity, and health equity. Watch for a Viewpoint series on team science to be published early this year.

The Journal published four Review Series, edited by members of our board:

Individual Reviews covered a range of subjects, from COVID-19 to gene therapy to metabolism.

Reminders:

  • ASCI members who are the corresponding author of a first-round submission to the JCI, and whose dues are current, may designate one submission per calendar year to be guaranteed for external peer review. For details, visit the JCI Information for Authors page.
  • Authors may transfer manuscripts from the preprint server bioRxiv and medRxiv for submission to the JCI.

I wish you a happy and productive New Year, and look forward to reading your best work.

Sincerely,

Rexford S. Ahima, MD, PhD
Editor, The Journal of Clinical Investigation

 

Corresponding authors who are ASCI members are indicated in bold.

Top-viewed JCI articles, 2020

Source: Google Analytics, December 29, 2020

The convalescent sera option for containing COVID-19
Viewpoint
Arturo Casadevall and Liise-anne Pirofski

Times viewed: 172,437

Clinical and immunological features of severe and moderate coronavirus disease 2019
Clinical Medicine
Guang Chen, Di Wu, Wei Guo, Yong Cao, Da Huang, Hongwu Wang, Tao Wang, Xiaoyun Zhang, Huilong Chen, Haijing Yu, Xiaoping Zhang, Minxia Zhang, Shiji Wu, Jianxin Song, Tao Chen, Meifang Han, Shusheng Li, Xiaoping Luo, Jianping Zhao, and Qin Ning

Times viewed: 48,645

Deployment of convalescent plasma for the prevention and treatment of COVID-19
Review
Evan M. Bloch, Shmuel Shoham, Arturo Casadevall, Bruce S. Sachais, Beth Shaz, Jeffrey L. Winters, Camille van Buskirk, Brenda J. Grossman, Michael Joyner, Jeffrey P. Henderson, Andrew Pekosz, Bryan Lau, Amy Wesolowski, Louis Katz, Hua Shan, Paul G. Auwaerter, David Thomas, David J. Sullivan, Nigel Paneth, Eric Gehrie, Steven Spitalnik, Eldad A. Hod, Lewis Pollack, Wayne T. Nicholson, Liise-anne Pirofski, Jeffrey A. Bailey, and Aaron A.R. Tobian

Times viewed: 45,365

SARS-CoV-2: a storm is raging
Commentary
Savannah F. Pedersen and Ya-Chi Ho

Times viewed: 44,426

Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists
Viewpoint
Maximilian F. Konig, Mike Powell, Verena Staedtke, Ren-Yuan Bai, David L. Thomas, Nicole Fischer, Sakibul Huq, Adham M. Khalafallah, Allison Koenecke, Ruoxuan Xiong, Brett Mensh, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Joshua T. Vogelstein, Susan Athey, Shibin Zhou, and Chetan Bettegowda

Times viewed: 15,768

Recent endemic coronavirus infection is associated with less-severe COVID-19
Concise Communication
Manish Sagar, Katherine Reifler, Michael Rossi, Nancy S. Miller, Pranay Sinha, Laura F. White, and Joseph P. Mizgerd

Times viewed: 14,447

Kinetics of viral load and antibody response in relation to COVID-19 severity
Research
Yanqun Wang, Lu Zhang, Ling Sang, Feng Ye, Shicong Ruan, Bei Zhong, Tie Song, Abeer N. Alshukairi, Rongchang Chen, Zhaoyong Zhang, Mian Gan, Airu Zhu, Yongbo Huang, Ling Luo, Chris Ka Pun Mok, Manal M. Al Gethamy, Haitao Tan, Zhengtu Li, Xiaofang Huang, Fang Li, Jing Sun, Yanjun Zhang, Liyan Wen, Yuming Li, Zhao Chen, Zhen Zhuang, Jianfen Zhuo, Chunke Chen, Lijun Kuang, Junxiang Wang, Huibin Lv, Yongliang Jiang, Min Li, Yimin Lin, Ying Deng, Lan Tang, Jieling Liang, Jicheng Huang, Stanley Perlman, Nanshan Zhong, Jingxian Zhao, J.S. Malik Peiris, Yimin Li, and Jincun Zhao

Times viewed: 10,647

The COVID-19 pandemic and research shutdown: staying safe and productive
Viewpoint
M. Bishr Omary, Jeetendra Eswaraka, S. David Kimball, Prabhas V. Moghe, Reynold A. Panettieri Jr., and Kathleen W. Scotto

Times viewed: 9,887

Early safety indicators of COVID-19 convalescent plasma in 5000 patients
Clinical Medicine
Michael J. Joyner, R. Scott Wright, DeLisa Fairweather, Jonathon W. Senefeld, Katelyn A. Bruno, Stephen A. Klassen, Rickey E. Carter, Allan M. Klompas, Chad C. Wiggins, John R.A. Shepherd, Robert F. Rea, Emily R. Whelan, Andrew J. Clayburn, Matthew R. Spiegel, Patrick W. Johnson, Elizabeth R. Lesser, Sarah E. Baker, Kathryn F. Larson, Juan G. Ripoll, Kylie J. Andersen, David O. Hodge, Katie L. Kunze, Matthew R. Buras, Matthew N.P. Vogt, Vitaly Herasevich, Joshua J. Dennis, Riley J. Regimbal, Philippe R. Bauer, Janis E. Blair, Camille M. Van Buskirk, Jeffrey L. Winters, James R. Stubbs, Nigel S. Paneth, Nicole C. Verdun, Peter Marks, and Arturo Casadevall

Times viewed: 8,344

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Research
Ethan R. Roy, Baiping Wang, Ying-wooi Wan, Gabriel Chiu, Allysa Cole, Zhuoran Yin, Nicholas E. Propson, Yin Xu, Joanna L. Jankowsky, Zhandong Liu, Virginia M.-Y. Lee, John Q. Trojanowski, Stephen D. Ginsberg, Oleg Butovsky, Hui Zheng, and Wei Cao1

Times viewed: 7,771

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2
Clinical Medicine
Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, and Hamid Bassiri

Times viewed: 6,962

 

The JCI in selected news outlets, 2020

Source: Altmetric, December 29, 2020

Early safety indicators of COVID-19 convalescent plasma in 5000 patients
Clinical Medicine

Mentioned in Popular Science

Clinical and immunological features of severe and moderate coronavirus disease 2019
Clinical Medicine

Mentioned in National Geographic; by National Public Radio (NPR)

BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of healthcare workers
Clinical Medicine
Magali Noval Rivas, Joseph E. Ebinger, Min Wu, Nancy Sun, Jonathan Braun, Kimia Sobhani, Jennifer E. Van Eyk, Susan Cheng, and Moshe Arditi

Mentioned in National Geographic, Popular Science

Residual endotoxin induces primary graft dysfunction through ischemia/reperfusion-primed alveolar macrophages
Research
Mahzad Akbarpour, Emilia Lecuona, Stephen F. Chiu, Qiang Wu, Melissa Querrey, Ramiro Fernandez, Félix L. Núñez-Santana, Haiying Sun, Sowmya Ravi, Chitaru Kurihara, James M. Walter, Nikita Joshi, Ziyou Ren, Scott C. Roberts, Alan Hauser, Daniel Kreisel, Wenjun Li, Navdeep S. Chandel, Alexander V. Misharin, Thalachallour Mohanakumar, G.R. Scott Budinger, and Ankit Bharat

Mentioned by CNN

The glucocorticoid receptor–FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder
Research
Haiyin Li, Ping Su, Terence K.Y. Lai, Anlong Jiang, Jing Liu, Dongxu Zhai, Charlie T.G. Campbell, Frankie H.F. Lee, WeiDong Yong, Suvercha Pasricha, Shupeng Li, Albert H.C. Wong, Kerry J. Ressler, and Fang Liu

Mentioned in Psychology Today

Genome-wide plasma DNA methylation features of metastatic prostate cancer
Research
Anjui Wu, Paolo Cremaschi, Daniel Wetterskog, Vincenza Conteduca, Gian Marco Franceschini, Dimitrios Kleftogiannis, Anuradha Jayaram, Shahneen Sandhu, Stephen Q. Wong, Matteo Benelli, Samanta Salvi, Giorgia Gurioli, Andrew Feber, Mariana Buongermino Pereira, Anna Maria Wingate, Enrique Gonzalez-Billalebeitia, Ugo De Giorgi, Francesca Demichelis, Stefano Lise, and Gerhardt Attard

Mentioned in the Daily Mail (United Kingdom)

Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities
Clinical Medicine
Chiara F. Magnani, Giuseppe Gaipa, Federico Lussana, Daniela Belotti, Giuseppe Gritti, Sara Napolitano, Giada Matera, Benedetta Cabiati, Chiara Buracchi, Gianmaria Borleri, Grazia Fazio, Silvia Zaninelli, Sarah Tettamanti, Stefania Cesana, Valentina Colombo, Michele Quaroni, Giovanni Cazzaniga, Attilio Rovelli, Ettore Biagi, Stefania Galimberti, Andrea Calabria, Fabrizio Benedicenti, Eugenio Montini, Silvia Ferrari, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, and Andrea Biondi

Mentioned in La Repubblica (Italy)

Climate change brings the specter of new infectious diseases
Viewpoint
Arturo Casadevall

Mentioned in Scientific American, Newsweek

 

Social media activity: Twitter

Source: Altmetric, December 29, 2020

Clinical and immunological features of severe and moderate coronavirus disease 2019
Clinical Medicine

Twitter mentions: 3,826

The convalescent sera option for containing COVID-19
Viewpoint

Twitter mentions: 2,643

SARS-CoV-2: a storm is raging
Commentary

Twitter mentions: 2,564

Recent endemic coronavirus infection is associated with less-severe COVID-19
Concise Communication

Twitter mentions: 1,088

Metabolic effects of air pollution exposure and reversibility
Concise Communication
Sanjay Rajagopalan, Bongsoo Park, Rengasamy Palanivel, Vinesh Vinayachandran, Jeffrey A. Deiuliis, Roopesh Singh Gangwar, Lopa Das, Jinhu Yin, Youngshim Choi, Sadeer Al-Kindi, Mukesh K. Jain, Kasper D. Hansen, and Shyam Biswal

Twitter mentions: 569

Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations
Research
Alexandra H. Mandarano, Jessica Maya, Ludovic Giloteaux, Daniel L. Peterson, Marco Maynard, C. Gunnar Gottschalk, and Maureen R. Hanson

Twitter mentions: 464

COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain
Clinical Medicine
Massimiliano Secchi, Elena Bazzigaluppi, Cristina Brigatti, Ilaria Marzinotto, Cristina Tresoldi, Patrizia Rovere-Querini, Andrea Poli, Antonella Castagna, Gabriella Scarlatti, Alberto Zangrillo, Fabio Ciceri, Lorenzo Piemonti, and Vito Lampasona

Twitter mentions: 349

 

Articles with ASCI members as corresponding authors in 2020

Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace
Research
Wan-Chi Lin, Kymberly M. Gowdy, Jennifer H. Madenspacher, Rachel L. Zemans, Kazuko Yamamoto, Miranda Lyons-Cohen, Hideki Nakano, Kyathanahalli Janardhan, Carmen J. Williams, Donald N. Cook, Joseph P. Mizgerd, and Michael B. Fessler
Increased expression of anion transporter SLC26A9 delays diabetes onset in cystic fibrosis
Research
Anh-Thu N. Lam, Melis A. Aksit, Briana Vecchio-Pagan, Celeste A. Shelton, Derek L. Osorio, Arianna F. Anzmann, Loyal A. Goff, David C. Whitcomb, Scott M. Blackman, and Garry R. Cutting
Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling
Research
Heather A. Himburg, Martina Roos, Tiancheng Fang, Yurun Zhang, Christina M. Termini, Lauren Schlussel, Mindy Kim, Amara Pang, Jenny Kan, Liman Zhao, Hyung Suh, Joshua P. Sasine, Gopal Sapparapu, Peter M. Bowers, Gary Schiller, and John P. Chute
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
Research
Andrew D. Hughes, Daqiang Zhao, Hehua Dai, Khodor I. Abou-Daya, Roger Tieu, Rayan Rammal, Amanda L. Williams, Douglas P. Landsittel, Warren D. Shlomchik, Adrian E. Morelli, Martin H. Oberbarnscheidt, and Fadi G. Lakkis
Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome
Research
Caitlin J. Bowen, Juan Francisco Calderón Giadrosic, Zachary Burger, Graham Rykiel, Elaine C. Davis, Mark R. Helmers, Kelly Benke, Elena Gallo MacFarlane, and Harry C. Dietz
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes
Research
Lauren K. Meyer, Benjamin J. Huang, Cristina Delgado-Martin, Ritu P. Roy, Aaron Hechmer, Anica M. Wandler, Tiffaney L. Vincent, Paolo Fortina, Adam B. Olshen, Brent L. Wood, Terzah M. Horton, Kevin M. Shannon, David T. Teachey, and Michelle L. Hermiston
Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes
Concise Communication
Jennie G. Ono, Benjamin I. Kim, Yize Zhao, Paul J. Christos, Yohannes Tesfaigzi, Tilla S. Worgall, and Stefan Worgall
GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein
Research
Jing Cheng, Linda R. Klei, Nathaniel E. Hubel, Ming Zhang, Rebekka Schairer, Lisa M. Maurer, Hanna B. Klei, Heejae Kang, Vincent J. Concel, Phillip C. Delekta, Eric V. Dang, Michelle A. Mintz, Mathijs Baens, Jason G. Cyster, Narayanan Parameswaran, Margot Thome, Peter C. Lucas, and Linda M. McAllister-Lucas
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
Clinical Medicine
Gordon I. Smith, Mahalakshmi Shankaran, Mihoko Yoshino, George G. Schweitzer, Maria Chondronikola, Joseph W. Beals, Adewole L. Okunade, Bruce W. Patterson, Edna Nyangau, Tyler Field, Claude B. Sirlin, Saswata Talukdar, Marc K. Hellerstein, and Samuel Klein
Chikungunya virus replication in skeletal muscle cells is required for disease development
Research
Anthony J. Lentscher, Mary K. McCarthy, Nicholas A. May, Bennett J. Davenport, Stephanie A. Montgomery, Krishnan Raghunathan, Nicole McAllister, Laurie A. Silva, Thomas E. Morrison, and Terence S. Dermody
Staphylococcus aureus toxin suppresses antigen-specific T cell responses
Concise Communication
Brandon Lee, Reuben Olaniyi, Jakub M. Kwiecinski, and Juliane Bubeck Wardenburg
Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy
Concise Communication
Jeremy M. Sullivan, William W. Motley, Janel O. Johnson, William H. Aisenberg, Katherine L. Marshall, Katy E.S. Barwick, Lingling Kong, Jennifer S. Huh, Pamela C. Saavedra-Rivera, Meriel M. McEntagart, Marie-Helene Marion, Lucy A. Hicklin, Hamid Modarres, Emma L. Baple, Mohamed H. Farah, Aamir R. Zuberi, Cathleen M. Lutz, Rachelle Gaudet, Bryan J. Traynor, Andrew H. Crosby, and Charlotte J. Sumner
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
Clinical Medicine
Adriana A. de Jesus, Yangfeng Hou, Stephen Brooks, Louise Malle, Angelique Biancotto, Yan Huang, Katherine R. Calvo, Bernadette Marrero, Susan Moir, Andrew J. Oler, Zuoming Deng, Gina A. Montealegre Sanchez, Amina Ahmed, Eric Allenspach, Bita Arabshahi, Edward Behrens, Susanne Benseler, Liliana Bezrodnik, Sharon Bout-Tabaku, AnneMarie C. Brescia, Diane Brown, Jon M. Burnham, Maria Soledad Caldirola, Ruy Carrasco, Alice Y. Chan, Rolando Cimaz, Paul Dancey, Jason Dare, Marietta DeGuzman, Victoria Dimitriades, Ian Ferguson, Polly Ferguson, Laura Finn, Marco Gattorno, Alexei A. Grom, Eric P. Hanson, Philip J. Hashkes, Christian M. Hedrich, Ronit Herzog, Gerd Horneff, Rita Jerath, Elizabeth Kessler, Hanna Kim, Daniel J. Kingsbury, Ronald M. Laxer, Pui Y. Lee, Min Ae Lee-Kirsch, Laura Lewandowski, Suzanne Li, Vibke Lilleby, Vafa Mammadova, Lakshmi N. Moorthy, Gulnara Nasrullayeva, Kathleen M. O’Neil, Karen Onel, Seza Ozen, Nancy Pan, Pascal Pillet, Daniela G.P. Piotto, Marilynn G. Punaro, Andreas Reiff, Adam Reinhardt, Lisa G. Rider, Rafael Rivas-Chacon, Tova Ronis, Angela Rösen-Wolff, Johannes Roth, Natasha Mckerran Ruth, Marite Rygg, Heinrike Schmeling, Grant Schulert, Christiaan Scott, Gisella Seminario, Andrew Shulman, Vidya Sivaraman, Mary Beth Son, Yuriy Stepanovskiy, Elizabeth Stringer, Sara Taber, Maria Teresa Terreri, Cynthia Tifft, Troy Torgerson, Laura Tosi, Annet Van Royen-Kerkhof, Theresa Wampler Muskardin, Scott W. Canna, and Raphaela Goldbach-Mansky
An endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability
Research
Oakleigh M. Folkes, Rita Báldi, Veronika Kondev, David J. Marcus, Nolan D. Hartley, Brandon D. Turner, Jade K. Ayers, Jordan J. Baechle, Maya P. Misra, Megan Altemus, Carrie A. Grueter, Brad A. Grueter, and Sachin Patel
Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis
Research
Liming Mao, Atsushi Kitani, Eitaro Hiejima, Kim Montgomery-Recht, Wenchang Zhou, Ivan Fuss, Adrian Wiestner, and Warren Strober
Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2
Concise Communication
Ritika Dutta, Tian Yi Zhang, Thomas Köhnke, Daniel Thomas, Miles Linde, Eric Gars, Melissa Stafford, Satinder Kaur, Yusuke Nakauchi, Raymond Yin, Armon Azizi, Anupama Narla, and Ravindra Majeti
Parathyroid hormone–dependent bone formation requires butyrate production by intestinal microbiota
Research
Jau-Yi Li, Mingcan Yu, Subhashis Pal, Abdul Malik Tyagi, Hamid Dar, Jonathan Adams, M. Neale Weitzmann, Rheinallt M. Jones, and Roberto Pacifici
Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease
Research
Joshua N. Curry, Matthew Saurette, Masomeh Askari, Lei Pei, Michael B. Filla, Megan R. Beggs, Peter S.N. Rowe, Timothy Fields, Andre J. Sommer, Chizu Tanikawa, Yoichiro Kamatani, Andrew P. Evan, Mehdi Totonchi, R. Todd Alexander, Koichi Matsuda, and Alan S.L. Yu
Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation
Research
Guadalupe Ortiz-Muñoz, Michelle A. Yu, Emma Lefrançais, Beñat Mallavia, Colin Valet, Jennifer J. Tian, Serena Ranucci, Kristin M. Wang, Zhe Liu, Nicholas Kwaan, Diana Dawson, Mary Ellen Kleinhenz, Fadi T. Khasawneh, Peter M. Haggie, Alan S. Verkman, and Mark R. Looney
Leptin mediates postprandial increases in body temperature through hypothalamus–adrenal medulla–adipose tissue crosstalk
Research
Rachel J. Perry, Kun Lyu, Aviva Rabin-Court, Jianying Dong, Xiruo Li, Yunfan Yang, Hua Qing, Andrew Wang, Xiaoyong Yang, and Gerald I. Shulman
Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis
Research
Jeongeun Hyun, Zhaoli Sun, Ali Reza Ahmadi, Sushant Bangru, Ullas V. Chembazhi, Kuo Du, Tianyi Chen, Hidekazu Tsukamoto, Ivan Rusyn, Auinash Kalsotra, and Anna Mae Diehl
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
Clinical Medicine
Alana E. O’Mara, James W. Johnson, Joyce D. Linderman, Robert J. Brychta, Suzanne McGehee, Laura A. Fletcher, Yael A. Fink, Devika Kapuria, Thomas M. Cassimatis, Nathan Kelsey, Cheryl Cero, Zahraa Abdul Sater, Francesca Piccinini, Alison S. Baskin, Brooks P. Leitner, Hongyi Cai, Corina M. Millo, William Dieckmann, Mary Walter, Norman B. Javitt, Yaron Rotman, Peter J. Walter, Marilyn Ader, Richard N. Bergman, Peter Herscovitch, Kong Y. Chen, and Aaron M. Cypess
The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans
Clinical Medicine
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, and Philip A. Kern
Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion
Clinical Medicine
Richard O. Francis, Angelo D’Alessandro, Andrew Eisenberger, Mark Soffing, Randy Yeh, Esther Coronel, Arif Sheikh, Francesca Rapido, Francesca La Carpia, Julie A. Reisz, Sarah Gehrke, Travis Nemkov, Tiffany Thomas, Joseph Schwartz, Chaitanya Divgi, Debra Kessler, Beth H. Shaz, Yelena Ginzburg, James C. Zimring, Steven L. Spitalnik, and Eldad A. Hod
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood
Research
Olivia Weeks, Gabriel D. Bossé, Isaac M. Oderberg, Sebastian Akle, Yariv Houvras, Paul J. Wrighton, Kyle LaBella, Isabelle Iversen, Sahar Tavakoli, Isaac Adatto, Arkadi Schwartz, Daan Kloosterman, Allison Tsomides, Michael E. Charness, Randall T. Peterson, Matthew L. Steinhauser, Pouneh K. Fazeli, and Wolfram Goessling
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
Research
Dario F. De Jesus, Kazuki Orime, Dorota Kaminska, Tomohiko Kimura, Giorgio Basile, Chih-Hao Wang, Larissa Haertle, Renzo Riemens, Natalie K. Brown, Jiang Hu, Ville Männistö, Amélia M. Silva, Ercument Dirice, Yu-Hua Tseng, Thomas Haaf, Jussi Pihlajamäki, and Rohit N. Kulkarni
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation
Research
Sandip M. Swain, Joelle M.-J. Romac, Rafiq A. Shahid, Stephen J. Pandol, Wolfgang Liedtke, Steven R. Vigna, and Rodger A. Liddle
BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo
Research
Yanqin Ren, Szu Han Huang, Shabnum Patel, Winiffer D. Conce Alberto, Dean Magat, Dughan Ahimovic, Amanda B. Macedo, Ryan Durga, Dora Chan, Elizabeth Zale, Talia M. Mota, Ronald Truong, Thomas Rohwetter, Chase D. McCann, Colin M. Kovacs, Erika Benko, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Alberto Bosque, Catherine M. Bollard, and R. Brad Jones
Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure
Research
Wei Zou, Nidhi Rohatgi, Jonathan R. Brestoff, John R. Moley, Yongjia Li, Jesse W. Williams, Yael Alippe, Hua Pan, Terri A. Pietka, Gabriel Mbalaviele, Elizabeth P. Newberry, Nicholas O. Davidson, Anwesha Dey, Kooresh I. Shoghi, Richard D. Head, Samuel A. Wickline, Gwendalyn J. Randolph, Nada A. Abumrad, and Steven L. Teitelbaum
Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis
Concise Communication
Bomi Lee, Julia Z. Adamska, Hong Namkoong, Melena D. Bellin, Josh Wilhelm, Gregory L. Szot, David M. Louis, Mark M. Davis, Stephen J. Pandol, and Aida Habtezion
Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin
Research
Jonathan N. Flak, Paulette B. Goforth, James Dell’Orco, Paul V. Sabatini, Chien Li, Nadejda Bozadjieva, Matthew Sorensen, Alec Valenta, Alan Rupp, Alison H. Affinati, Corentin Cras-Méneur, Ahsan Ansari, Jamie Sacksner, Nandan Kodur, Darleen A. Sandoval, Robert T. Kennedy, David P. Olson, and Martin G. Myers Jr.
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury
Research
Jihoon Nah, Peiyong Zhai, Chun-Yang Huang, Álvaro F. Fernández, Satvik Mareedu, Beth Levine, and Junichi Sadoshima
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling
Research
Austin Hsu, Qiming Duan, Sarah McMahon, Yu Huang, Sarah A.B. Wood, Nathanael S. Gray, Biao Wang, Benoit G. Bruneau, and Saptarsi M. Haldar
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer
Research
Manjie Xing, Wen Fong Ooi, Jing Tan, Aditi Qamra, Po-Hsien Lee, Zhimei Li, Chang Xu, Nisha Padmanabhan, Jing Quan Lim, Yu Amanda Guo, Xiaosai Yao, Mandoli Amit, Ley Moy Ng, Taotao Sheng, Jing Wang, Kie Kyon Huang, Chukwuemeka George Anene-Nzelu, Shamaine Wei Ting Ho, Mohana Ray, Lijia Ma, Gregorio Fazzi, Kevin Junliang Lim, Giovani Claresta Wijaya, Shenli Zhang, Tannistha Nandi, Tingdong Yan, Mei Mei Chang, Kakoli Das, Zul Fazreen Adam Isa, Jeanie Wu, Polly Suk Yean Poon, Yue Ning Lam, Joyce Suling Lin, Su Ting Tay, Ming Hui Lee, Angie Lay Keng Tan, Xuewen Ong, Kevin White, Steven George Rozen, Michael Beer, Roger Sik Yin Foo, Heike Irmgard Grabsch, Anders Jacobsen Skanderup, Shang Li, Bin Tean Teh, and Patrick Tan
Inherited human IFN-γ deficiency underlies mycobacterial disease
Research
Gaspard Kerner, Jérémie Rosain, Antoine Guérin, Ahmad Al-Khabaz, Carmen Oleaga-Quintas, Franck Rapaport, Michel J. Massaad, Jing-Ya Ding, Taushif Khan, Fatima Al Ali, Mahbuba Rahman, Caroline Deswarte, Rubén Martinez-Barricarte, Raif S. Geha, Valentine Jeanne-Julien, Diane Garcia, Chih-Yu Chi, Rui Yang, Manon Roynard, Bernhard Fleckenstein, Flore Rozenberg, Stéphanie Boisson-Dupuis, Cheng-Lung Ku, Yoann Seeleuthner, Vivien Béziat, Nico Marr, Laurent Abel, Waleed Al-Herz, Jean-Laurent Casanova, and Jacinta Bustamante
B cell–intrinsic TLR9 expression is protective in murine lupus
Research
Jeremy S. Tilstra, Shinu John, Rachael A. Gordon, Claire Leibler, Michael Kashgarian, Sheldon Bastacky, Kevin M. Nickerson, and Mark J. Shlomchik
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration
Research
Abhishek Jauhari, Sergei V. Baranov, Yalikun Suofu, Jinho Kim, Tanisha Singh, Svitlana Yablonska, Fang Li, Xiaomin Wang, Patrick Oberly, M. Beth Minnigh, Samuel M. Poloyac, Diane L. Carlisle, and Robert M. Friedlander
Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection
Research
Xiaoming Cheng, Takuro Uchida, Yuchen Xia, Regina Umarova, Chun-Jen Liu, Pei-Jer Chen, Anuj Gaggar, Vithika Suri, Marcus M. Mücke, Johannes Vermehren, Stefan Zeuzem, Yuji Teraoka, Mitsutaka Osawa, Hiroshi Aikata, Keiji Tsuji, Nami Mori, Shuhei Hige, Yoshiyasu Karino, Michio Imamura, Kazuaki Chayama, and T. Jake Liang
Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics
Clinical Medicine
Gordon I. Smith, David C. Polidori, Mihoko Yoshino, Monica L. Kearney, Bruce W. Patterson, Bettina Mittendorfer, and Samuel Klein
Taxane resistance in prostate cancer is mediated by decreased drug-target engagement
Research
Ada Gjyrezi, Fang Xie, Olga Voznesensky, Prateek Khanna, Carla Calagua, Yang Bai, Justin Kung, Jim Wu, Eva Corey, Bruce Montgomery, Sandrine Mace, Diego A. Gianolio, Glenn J. Bubley, Steven P. Balk, Paraskevi Giannakakou, and Rupal S. Bhatt
Longitudinal study reveals HIV-1–infected CD4+ T cell dynamics during long-term antiretroviral therapy
Research
Annukka A.R. Antar, Katharine M. Jenike, Sunyoung Jang, Danielle N. Rigau, Daniel B. Reeves, Rebecca Hoh, Melissa R. Krone, Jeanne C. Keruly, Richard D. Moore, Joshua T. Schiffer, Bareng A.S. Nonyane, Frederick M. Hecht, Steven G. Deeks, Janet D. Siliciano, Ya-Chi Ho, and Robert F. Siliciano
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation
Research
Wenqiang Cao, Fengqin Fang, Timothy Gould, Xuanying Li, Chulwoo Kim, Claire Gustafson, Simon Lambert, Cornelia M. Weyand, and Jörg J. Goronzy
Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility
Research
Lan Ye, Ge Li, Anna Goebel, Abhinav V. Raju, Feng Kong, Yanfei Lv, Kailin Li, Yuanjun Zhu, Shreya Raja, Peijian He, Fang Li, Simon Musyoka Mwangi, Wenhui Hu, and Shanthi Srinivasan
Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis
Clinical Medicine
Vance G. Fowler Jr., Anita F. Das, Joy Lipka-Diamond, Raymond Schuch, Roger Pomerantz, Luis Jáuregui-Peredo, Adam Bressler, David Evans, Gregory J. Moran, Mark E. Rupp, Robert Wise, G. Ralph Corey, Marcus Zervos, Pamela S. Douglas, and Cara Cassino
Macrophages use a bet-hedging strategy for antimicrobial activity in phagolysosomal acidification
Research
Quigly Dragotakes, Kaitlin M. Stouffer, Man Shun Fu, Yehonatan Sella, Christine Youn, Olivia Insun Yoon, Carlos M. De Leon-Rodriguez, Joudeh B. Freij, Aviv Bergman, and Arturo Casadevall
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
Research
Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell
Complement factor H–deficient mice develop spontaneous hepatic tumors
Research
Jennifer Laskowski, Brandon Renner, Matthew C. Pickering, Natalie J. Serkova, Peter M. Smith-Jones, Eric T. Clambey, Raphael A. Nemenoff, and Joshua M. Thurman
Gut microbiome communication with bone marrow regulates susceptibility to amebiasis
Concise Communication
Stacey L. Burgess, Jhansi L. Leslie, Jashim Uddin, David N. Oakland, Carol Gilchrist, G. Brett Moreau, Koji Watanabe, Mahmoud Saleh, Morgan Simpson, Brandon A. Thompson, David T. Auble, Stephen D. Turner, Natasa Giallourou, Jonathan Swann, Zhen Pu, Jennie Z. Ma, Rashidul Haque, and William A. Petri Jr.
Long-range cis-regulatory elements controlling GDF6 expression are essential for ear development
Concise Communication
Guney Bademci, Clemer Abad, Filiz B. Cengiz, Serhat Seyhan, Armagan Incesulu, Shengru Guo, Suat Fitoz, Emine Ikbal Atli, Nicholas C. Gosstola, Selma Demir, Brett M. Colbert, Gozde Cosar Seyhan, Claire J. Sineni, Duygu Duman, Hakan Gurkan, Cynthia C. Morton, Derek M. Dykxhoorn, Katherina Walz, and Mustafa Tekin
Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets
Research
Matt R. Paul, Tien-chi Pan, Dhruv K. Pant, Natalie N.C. Shih, Yan Chen, Kyra L. Harvey, Aaron Solomon, David Lieberman, Jennifer J.D. Morrissette, Danielle Soucier-Ernst, Noah G. Goodman, S. William Stavropoulos, Kara N. Maxwell, Candace Clark, George K. Belka, Michael Feldman, Angela DeMichele, and Lewis A. Chodosh
AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes
Research
Ali Dehnad, Weiguo Fan, Joy X. Jiang, Sarah R. Fish, Yuan Li, Suvarthi Das, Gergely Mozes, Kimberly A. Wong, Kristin A. Olson, Gregory W. Charville, Mohammed Ali, and Natalie J. Török
Residual endotoxin induces primary graft dysfunction through ischemia/reperfusion-primed alveolar macrophages
Research
Mahzad Akbarpour, Emilia Lecuona, Stephen F. Chiu, Qiang Wu, Melissa Querrey, Ramiro Fernandez, Félix L. Núñez-Santana, Haiying Sun, Sowmya Ravi, Chitaru Kurihara, James M. Walter, Nikita Joshi, Ziyou Ren, Scott C. Roberts, Alan Hauser, Daniel Kreisel, Wenjun Li, Navdeep S. Chandel, Alexander V. Misharin, Thalachallour Mohanakumar, G.R. Scott Budinger, and Ankit Bharat
Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity
Research
Ze Zheng, Keiko Nakamura, Shana Gershbaum, Xiaobo Wang, Sherry Thomas, Marc Bessler, Beth Schrope, Abraham Krikhely, Rui-Ming Liu, Lale Ozcan, José A. López, and Ira Tabas
Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy
Research
Rocio Bengoechea, Andrew R. Findlay, Ankan K. Bhadra, Hao Shao, Kevin C. Stein, Sara K. Pittman, Jil A.W. Daw, Jason E. Gestwicki, Heather L. True, and Conrad C. Weihl
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness
Research
Haiquan Lu, Yangyiran Xie, Linh Tran, Jie Lan, Yongkang Yang, Naveena L. Murugan, Ru Wang, Yueyang J. Wang, and Gregg L. Semenza
FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages
Research
Arielle M. Bryan, Jeehyun Karen You, Travis McQuiston, Cristina Lazzarini, Zhijuan Qiu, Brian Sheridan, Barbara Nuesslein-Hildesheim, and Maurizio Del Poeta
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease
Research
Sherrie J. Divito, Anders T. Aasebø, Tiago R. Matos, Pei-Chen Hsieh, Matthew Collin, Christopher P. Elco, John T. O’Malley, Espen S. Bækkevold, Henrik Reims, Tobias Gedde-Dahl, Michael Hagerstrom, Jude Hilaire, John W. Lian, Edgar L. Milford, Geraldine S. Pinkus, Vincent T. Ho, Robert J. Soiffer, Haesook T. Kim, Martin C. Mihm, Jerome Ritz, Indira Guleria, Corey S. Cutler, Rachael A. Clark, Frode L. Jahnsen, and Thomas S. Kupper
Anti–influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface
Concise Communication
Jinhui Dong, Iuliia Gilchuk, Sheng Li, Ryan Irving, Matthew T. Goff, Hannah L. Turner, Andrew B. Ward, Robert H. Carnahan, and James E. Crowe Jr.
Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis
Research
Melanie C. Dispenza, Rebecca A. Krier-Burris, Krishan D. Chhiba, Bradley J. Undem, Piper A. Robida, and Bruce S. Bochner
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII
Research
Klitos Konstantinidis, Vassilios J. Bezzerides, Lo Lai, Holly M. Isbell, An-Chi Wei, Yuejin Wu, Meera C. Viswanathan, Ian D. Blum, Jonathan M. Granger, Danielle Heims-Waldron, Donghui Zhang, Elizabeth D. Luczak, Kevin R. Murphy, Fujian Lu, Daniel H. Gratz, Bruno Manta, Qiang Wang, Qinchuan Wang, Alex L. Kolodkin, Vadim N. Gladyshev, Thomas J. Hund, William T. Pu, Mark N. Wu, Anthony Cammarato, Mario A. Bianchet, Madeline A. Shea, Rodney L. Levine, and Mark E. Anderson
Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias
Research
Shaohua Xiao, Daisuke Shimura, Rachel Baum, Diana M. Hernandez, Sosse Agvanian, Yoshiko Nagaoka, Makoto Katsumata, Paul D. Lampe, Andre G. Kleber, TingTing Hong, and Robin M. Shaw
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration
Research
Maud Gratuze, Cheryl E.G. Leyns, Andrew D. Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T. Kummer, Marco Colonna, Jason D. Ulrich, and David M. Holtzman
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice
Research
Preeti Raju, Nitesh Shashikanth, Pei-Yun Tsai, Pawin Pongkorpsakol, Sandra Chanez-Paredes, Peter R. Steinhagen, Wei-Ting Kuo, Gurminder Singh, Sachiko Tsukita, and Jerrold R. Turner
Mapping mania symptoms based on focal brain damage
Clinical Medicine
Gonçalo Cotovio, Daniel Talmasov, J. Bernardo Barahona-Corrêa, Joey Hsu, Suhan Senova, Ricardo Ribeiro, Louis Soussand, Ana Velosa, Vera Cruz e Silva, Natalia Rost, Ona Wu, Alexander L. Cohen, Albino J. Oliveira-Maia, and Michael D. Fox
Human NK cell deficiency as a result of biallelic mutations in MCM10
Research
Emily M. Mace, Silke Paust, Matilde I. Conte, Ryan M. Baxley, Megan M. Schmit, Sagar L. Patil, Nicole C. Guilz, Malini Mukherjee, Ashley E. Pezzi, Jolanta Chmielowiec, Swetha Tatineni, Ivan K. Chinn, Zeynep Coban Akdemir, Shalini N. Jhangiani, Donna M. Muzny, Asbjørg Stray-Pedersen, Rachel E. Bradley, Mo Moody, Philip P. Connor, Adrian G. Heaps, Colin Steward, Pinaki P. Banerjee, Richard A. Gibbs, Malgorzata Borowiak, James R. Lupski, Stephen Jolles, Anja K. Bielinsky, and Jordan S. Orange
Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia
Research
Andrew Crispin, Chaoshe Guo, Caiyong Chen, Dean R. Campagna, Paul J. Schmidt, Daniel Lichtenstein, Chang Cao, Anoop K. Sendamarai, Gordon J. Hildick-Smith, Nicholas C. Huston, Jeanne Boudreaux, Sylvia S. Bottomley, Matthew M. Heeney, Barry H. Paw, Mark D. Fleming, and Sarah Ducamp
Improved killing of HIV-infected cells using three neutralizing and non-neutralizing antibodies
Research
Marina Tuyishime, Carolina Garrido, Shalini Jha, Matt Moeser, Dieter Mielke, Celia LaBranche, David Montefiori, Barton F. Haynes, Sarah Joseph, David M. Margolis, and Guido Ferrari
A coagulation defect arising from heterozygous premature termination of tissue factor
Research
Sol Schulman, Emale El-Darzi, Mary H.C. Florido, Max Friesen, Glenn Merrill-Skoloff, Marisa A. Brake, Calvin R. Schuster, Lin Lin, Randal J. Westrick, Chad A. Cowan, Robert Flaumenhaft, NIHR BioResource, Willem H. Ouwehand, Kathelijne Peerlinck, Kathleen Freson, Ernest Turro, and Bruce Furie
Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression
Research
Anqun Chen, Ye Feng, Han Lai, Wenjun Ju, Zhengzhe Li, Yu Li, Andrew Wang, Quan Hong, Fang Zhong, Chengguo Wei, Jia Fu, Tianjun Guan, Bichen Liu, Matthias Kretzler, Kyung Lee, and John Cijiang He
Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema
Research
Xinguo Jiang, Wen Tian, Eric J. Granucci, Allen B. Tu, Dongeon Kim, Petra Dahms, Shravani Pasupneti, Gongyong Peng, Yesl Kim, Amber H. Lim, F. Hernan Espinoza, Matthew Cribb, J. Brandon Dixon, Stanley G. Rockson, Gregg L. Semenza, and Mark R. Nicolls
Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients
Research
Kazusa Ishii, Marie Pouzolles, Christopher D. Chien, Rebecca A. Erwin-Cohen, M. Eric Kohler, Haiying Qin, Haiyan Lei, Skyler Kuhn, Amanda K. Ombrello, Alina Dulau-Florea, Michael A. Eckhaus, Haneen Shalabi, Bonnie Yates, Daniel A. Lichtenstein, Valérie S. Zimmermann, Taisuke Kondo, Jack F. Shern, Howard A. Young, Naomi Taylor, Nirali N. Shah, and Terry J. Fry
Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder
Clinical Medicine
Matthew K. Schindler, Stefania Pittaluga, Yoshimi Enose-Akahata, Helen C. Su, V. Koneti Rao, Amy Rump, Steven Jacobson, Irene Cortese, Daniel S. Reich, and Gulbu Uzel
DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas
Research
Anat Ben-Shlomo, Nan Deng, Evelyn Ding, Masaaki Yamamoto, Adam Mamelak, Vera Chesnokova, Artak Labadzhyan, and Shlomo Melmed
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming
Research
Fei Li, Qiuyue Yuan, Wei Di, Xinyi Xia, Zhuang Liu, Ninghui Mao, Lin Li, Chunfeng Li, Juan He, Yunguang Li, Wangxin Guo, Xiaoyu Zhang, Yiqin Zhu, Rebiguli Aji, Shangqian Wang, Xinyuan Tong, Hongbin Ji, Ping Chi, Brett Carver, Yong Wang, Yu Chen, and Dong Gao
Complement activation on endothelium initiates antibody-mediated acute lung injury
Research
Simon J. Cleary, Nicholas Kwaan, Jennifer J. Tian, Daniel R. Calabrese, Beñat Mallavia, Mélia Magnen, John R. Greenland, Anatoly Urisman, Jonathan P. Singer, Steven R. Hays, Jasleen Kukreja, Ariel M. Hay, Heather L. Howie, Pearl Toy, Clifford A. Lowell, Craig N. Morrell, James C. Zimring, and Mark R. Looney
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2
Clinical Medicine
Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, and Hamid Bassiri
Metabolic effects of air pollution exposure and reversibility
Concise Communication
Sanjay Rajagopalan, Bongsoo Park, Rengasamy Palanivel, Vinesh Vinayachandran, Jeffrey A. Deiuliis, Roopesh Singh Gangwar, Lopa Das, Jinhu Yin, Youngshim Choi, Sadeer Al-Kindi, Mukesh K. Jain, Kasper D. Hansen, and Shyam Biswal
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure
Clinical Medicine
Bo Zhou, Dennis Ding-Hwa Wang, Yanhua Qiu, Sophia Airhart, Yaxin Liu, April Stempien-Otero, Kevin D. O’Brien, and Rong Tian
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma
Research
Jason Yongsheng Chan, Jing Quan Lim, Joe Yeong, Vinod Ravi, Peiyong Guan, Arnoud Boot, Timothy Kwang Yong Tay, Sathiyamoorthy Selvarajan, Nur Diyana Md Nasir, Jie Hua Loh, Choon Kiat Ong, Dachuan Huang, Jing Tan, Zhimei Li, Cedric Chuan-Young Ng, Thuan Tong Tan, Mikio Masuzawa, Ken Wing-Kin Sung, Mohamad Farid, Richard Hong Hui Quek, Ngian Chye Tan, Melissa Ching Ching Teo, Steven George Rozen, Patrick Tan, Andrew Futreal, Bin Tean Teh, and Khee Chee Soo
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population
Research
Sabra L. Klein, Andrew Pekosz, Han-Sol Park, Rebecca L. Ursin, Janna R. Shapiro, Sarah E. Benner, Kirsten Littlefield, Swetha Kumar, Harnish Mukesh Naik, Michael J. Betenbaugh, Ruchee Shrestha, Annie A. Wu, Robert M. Hughes, Imani Burgess, Patricio Caturegli, Oliver Laeyendecker, Thomas C. Quinn, David Sullivan, Shmuel Shoham, Andrew D. Redd, Evan M. Bloch, Arturo Casadevall, and Aaron A.R. Tobian
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma
Clinical Medicine
Sabine Mueller, Jared M. Taitt, Javier E. Villanueva-Meyer, Erin R. Bonner, Takahide Nejo, Rishi R. Lulla, Stewart Goldman, Anu Banerjee, Susan N. Chi, Nicholas S. Whipple, John R. Crawford, Karen Gauvain, Kellie J. Nazemi, Payal B. Watchmaker, Neil D. Almeida, Kaori Okada, Andres M. Salazar, Ryan D. Gilbert, Javad Nazarian, Annette M. Molinaro, Lisa H. Butterfield, Michael D. Prados, and Hideho Okada
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris
Concise Communication
Jinmin Lee, Daniel K. Lundgren, Xuming Mao, Silvio Manfredo-Vieira, Selene Nunez-Cruz, Erik F. Williams, Charles-Antoine Assenmacher, Enrico Radaelli, Sangwook Oh, Baomei Wang, Christoph T. Ellebrecht, Joseph A. Fraietta, Michael C. Milone, and Aimee S. Payne
Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion
Research
Valerie Clerin, Hiroshi Saito, Kevin J. Filipski, An Hai Nguyen, Jeonifer Garren, Janka Kisucka, Monica Reyes, and Harald Jüppner
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity
Clinical Medicine
Vincenza Cifarelli, Scott C. Beeman, Gordon I. Smith, Jun Yoshino, Darya Morozov, Joseph W. Beals, Brandon D. Kayser, Jeramie D. Watrous, Mohit Jain, Bruce W. Patterson, and Samuel Klein
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity
Research
Selami Demirci, Jing Zeng, Yuxuan Wu, Naoya Uchida, Anne H. Shen, Danilo Pellin, Jackson Gamer, Morgan Yapundich, Claire Drysdale, Jasmine Bonanno, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Theresa Engels, Robert E. Donahue, Juan J. Haro-Mora, Alexis Leonard, Tina Nassehi, Kevin Luk, Shaina N. Porter, Cicera R. Lazzarotto, Shengdar Q. Tsai, Mitchell J. Weiss, Shondra M. Pruett-Miller, Scot A. Wolfe, Daniel E. Bauer, and John F. Tisdale
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Research
Eric Salazar, Suresh V. Kuchipudi, Paul A. Christensen, Todd Eagar, Xin Yi, Picheng Zhao, Zhicheng Jin, S. Wesley Long, Randall J. Olsen, Jian Chen, Brian Castillo, Christopher Leveque, Dalton Towers, Jason Lavinder, Jimmy Gollihar, Jose Cardona, Gregory Ippolito, Ruth Nissly, Ian Bird, Denver Greenawalt, Randall M. Rossi, Abhinay Gontu, Sreenidhi Srinivasan, Indira Poojary, Isabella M. Cattadori, Peter J. Hudson, Nicole M. Josleyn, Laura Prugar, Kathleen Huie, Andrew Herbert, David W. Bernard, John M. Dye, Vivek Kapur, and James M. Musser
Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance
Research
Wenjun Li, Jason M. Gauthier, Alice Y. Tong, Yuriko Terada, Ryuji Higashikubo, Christian C. Frye, Margaret S. Harrison, Kohei Hashimoto, Amit I. Bery, Jon H. Ritter, Ruben G. Nava, Varun Puri, Brian W. Wong, Kory J. Lavine, Ankit Bharat, Alexander S. Krupnick, Andrew E. Gelman, and Daniel Kreisel
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor
Research
Justin Taylor, Mark T.A. Donoghue, Caleb Ho, Kseniya Petrova-Drus, Hikmat A. Al-Ahmadie, Samuel A. Funt, Yanming Zhang, Umut Aypar, Pavitra Rao, Shweta S. Chavan, Michael Haddadin, Roni Tamari, Sergio Giralt, Martin S. Tallman, Raajit K. Rampal, Priscilla Baez, Rajya Kappagantula, Satyajit Kosuri, Ahmet Dogan, Satish K. Tickoo, Victor E. Reuter, George J. Bosl, Christine A. Iacobuzio-Donahue, David B. Solit, Barry S. Taylor, Darren R. Feldman, and Omar Abdel-Wahab
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2
Clinical Medicine
Bezawit A. Woldemeskel, Abena K. Kwaa, Caroline C. Garliss, Oliver Laeyendecker, Stuart C. Ray, and Joel N. Blankson

Posted in JCI

JCI Editor’s update, December 2019

Posted on by Maya Hoptman

Dear Colleague,

As the year draws to a close, I wanted to take the opportunity to update you on recent JCI activity. The Journal continues to build on its history of publishing outstanding biomedical research, garnering wide attention in the scientific literature, the press, and social media (highlighted below). In particular, the Clinical Medicine category, now in its seventh year, continues to flourish, with 25 articles published in 2019. Among these were two of the highest-cited JCI papers of the year, on the role of androgen receptor splice variant-7 in castration-resistant prostate cancer; and the use of B cell maturation antigen–targeted CAR T cells in multiple myeloma. We welcome submissions from ASCI members reporting new medical therapies, interventions, diagnostic advances, or observational studies in humans that have the potential to change medical practice.

Viewpoint articles have given voice to experts and thought leaders in medicine, academia, nonprofit organizations, industry, and representatives of the JCI and ASCI on subjects of topical and long-term interest. In one recent Viewpoint (available here), the women on the JCI Editorial Board share their perspective on achieving equity for women and underrepresented minorities in academic medicine leadership, including in societies and journals. In another, Kieren Marr (2018-19 ASCI President) et al. discuss the Society’s strategic support of physician-scientists. In early January, look for a series of Viewpoints on the effects of climate change on human health.

The Journal published four Review Series this year, on mechanisms underlying the metabolic syndrome, reparative immunology, allergy, and familial cancer predisposition syndromes, the latter three with series editors who are ASCI members. Individual Reviews covered a range of subjects, from vaccines to endocrinology to neurology, including a highly cited article on the functional significance of platelet immune receptors.

Reminders:

  • ASCI members who are the corresponding author of a first-round submission to the JCI, and whose dues are current, may designate one submission per calendar year to be guaranteed for external peer review. For details, visit the For Authors page.
  • Authors may transfer manuscripts from the preprint server bioRxiv for submission to the JCI.

I wish you all the best for the New Year, and look forward to reading your best work.

Sincerely,

Rexford S. Ahima, MD, PhD
Editor, The Journal of Clinical Investigation

The JCI in selected news outlets, 2019

Source: Altmetric. Corresponding authors who are ASCI members are indicated in bold.

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases
Research
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, and Lei Liu

Mentioned in BBC News

Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Research
Matthew C. Madison, Cameron T. Landers, Bon-Hee Gu, Cheng-Yen Chang, Hui-Ying Tung, Ran You, Monica J. Hong, Nima Baghaei, Li-Zhen Song, Paul Porter, Nagireddy Putluri, Ramiro Salas, Brian E. Gilbert, Ilya Levental, Matthew J. Campen, David B. Corry, and Farrah Kheradmand

Mentioned in Japan Times; Haaretz (Israel); US News and World Report; WIRED

The physician-scientist: defending vaccines and combating antiscience
Viewpoint
Peter Hotez

Mentioned in Newsweek

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease
Clinical Medicine
David C. Fajgenbaum, Ruth-Anne Langan, Alberto Sada Japp, Helen L. Partridge, Sheila K. Pierson, Amrit Singh, Daniel J. Arenas, Jason R. Ruth, Christopher S. Nabel, Katie Stone, Mariko Okumura, Anthony Schwarer, Fábio Freire Jose, Nelson Hamerschlak, Gerald B. Wertheim, Michael B. Jordan, Adam D. Cohen, Vera Krymskaya, Arthur Rubenstein, Michael R. Betts, Taku Kambayashi, Frits van Rhee, and Thomas S. Uldrick

Mentioned in Newsweek

Cingulum stimulation enhances positive affect and anxiolysis to facilitate awake craniotomy
Clinical Medicine
Kelly R. Bijanki, Joseph R. Manns, Cory S. Inman, Ki Sueng Choi, Sahar Harati, Nigel P. Pedersen, Daniel L. Drane, Allison C. Waters, Rebecca E. Fasano, Helen S. Mayberg, and Jon T. Willie

Mentioned in Discover Magazine and Der Spiegel

Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition
Concise Communication
Kentaro Kaneko, Yukiko Fu, Hsiao-Yun Lin, Elizabeth L. Cordonier, Qianxing Mo, Yong Gao, Ting Yao, Jacqueline Naylor, Victor Howard, Kenji Saito, Pingwen Xu, Siyu S. Chen, Miao-Hsueh Chen, Yong Xu, Kevin W. Williams, Peter Ravn, and Makoto Fukuda

Mentioned in Wiener-Zeitung (Austria); Daily Mail (United Kingdom)

Social media activity: Twitter

Source: Altmetric, November 2019. Corresponding authors who are ASCI members are indicated in bold.

Promises, promises, and precision medicine
Viewpoint
Michael J. Joyner and Nigel Paneth

Twitter mentions: 395

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases
Research
Dipak Panigrahy, Allison Gartung, Jun Yang, Haixia Yang, Molly M. Gilligan, Megan L. Sulciner, Swati S. Bhasin, Diane R. Bielenberg, Jaimie Chang, Birgitta A. Schmidt, Julia Piwowarski, Anna Fishbein, Dulce Soler-Ferran, Matthew A. Sparks, Steven J. Staffa, Vidula Sukhatme, Bruce D. Hammock, Mark W. Kieran, Sui Huang, Manoj Bhasin, Charles N. Serhan, and Vikas P. Sukhatme

Twitter mentions: 322

Elevation of plasma tRNA fragments precedes seizures in human epilepsy
Concise Communication
Marion C. Hogg, Rana Raoof, Hany El Naggar, Naser Monsefi, Norman Delanty, Donncha F. O’Brien, Sebastian Bauer, Felix Rosenow, David C. Henshall, and Jochen H.M. Prehn

Twitter mentions: 218

Highest-cited research published in 2019

Source: Web of Science as of November 25, 2019. Corresponding authors who are ASCI members are indicated in bold.

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer
Clinical Medicine
Adam Sharp, Ilsa Coleman, Wei Yuan, Cynthia Sprenger, David Dolling, Daniel Nava Rodrigues, Joshua W. Russo, Ines Figueiredo, Claudia Bertan, George Seed, Ruth Riisnaes, Takuma Uo, Antje Neeb, Jonathan Welti, Colm Morrissey, Suzanne Carreira, Jun Luo, Peter S. Nelson, Steven P. Balk, Lawrence D. True, Johann S. de Bono, and Stephen R. Plymate

Times cited: 23

APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production
Research
Feng-Wei Wang, Chen-Hui Cao, Kai Han, Yong-Xiang Zhao, Mu-Yan Cai, Zhi-Cheng Xiang, Jia-Xing Zhang, Jie-Wei Chen, Li-Ping Zhong, Yong Huang, Su-Fang Zhou, Xiao-Han Jin, Xin-Yuan Guan, Rui-Hua Xu, and Dan Xie

Times cited: 22

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer
Research
Roman M. Chabanon, Gareth Muirhead, Dragomir B. Krastev, Julien Adam, Daphné Morel, Marlène Garrido, Andrew Lamb, Clémence Hénon, Nicolas Dorvault, Mathieu Rouanne, Rebecca Marlow, Ilirjana Bajrami, Marta Llorca Cardeñosa, Asha Konde, Benjamin Besse, Alan Ashworth, Stephen J. Pettitt, Syed Haider, Aurélien Marabelle, Andrew N.J. Tutt, Jean-Charles Soria, Christopher J. Lord, and Sophie Postel-Vinay

Times cited: 14

B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma
Clinical Medicine
Adam D. Cohen, Alfred L. Garfall, Edward A. Stadtmauer, J. Joseph Melenhorst, Simon F. Lacey, Eric Lancaster, Dan T. Vogl, Brendan M. Weiss, Karen Dengel, Annemarie Nelson, Gabriela Plesa, Fang Chen, Megan M. Davis, Wei-Ting Hwang, Regina M. Young, Jennifer L. Brogdon, Randi Isaacs, Iulian Pruteanu-Malinici, Don L. Siegel, Bruce L. Levine, Carl H. June, and Michael C. Milone

Times cited: 13

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis
Research
Yongsheng Yu, Yu Liu, Weishuai An, Jingwen Song, Yuefan Zhang, and Xianxian Zhao

Times cited: 12

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia
Research
Toshiro Saito, Jihoon Nah, Shin-ichi Oka, Risa Mukai, Yoshiya Monden, Yasuhiro Maejima, Yoshiyuki Ikeda, Sebastiano Sciarretta, Tong Liu, Hong Li, Erdene Baljinnyam, Diego Fraidenraich, Luke Fritzky, Peiyong Zhai, Shizuko Ichinose, Mitsuaki Isobe, Chiao-Po Hsu, Mondira Kundu, and Junichi Sadoshima

Times cited: 12

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Research
Yong Pan, Xiaoyan Hui, Ruby Lai Chong Hoo, Dewei Ye, Cyrus Yuk Cheung Chan, Tianshi Feng, Yu Wang, Karen Siu Ling Lam, and Aimin Xu

Times cited: 12

Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression
Research
Bing Song, Su-Hong Park, Jonathan C. Zhao, Ka-wing Fong, Shangze Li, Yongik Lee, Yeqing A. Yang, Subhasree Sridhar, Xiaodong Lu, Sarki A. Abdulkadir, Robert L. Vessella, Colm Morrissey, Timothy M. Kuzel, William Catalona, Ximing Yang, and Jindan Yu

Times cited: 10

JCI research with ASCI members as corresponding authors, 2019

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup
Stephanie A. Christenson, Maarten van den Berge, Alen Faiz, Kai Inkamp, Nirav Bhakta, Luke R. Bonser, Lorna T. Zlock, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Richard C. Boucher, Russell P. Bowler, Alejandro P. Comellas, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Pieter S. Hiemstra, Robert J. Kaner, Jerry A. Krishnanm, Fernando J. Martinez, Wanda K. O’Neal, Robert Paine III, Wim Timens, J. Michael Wells, Avrum Spira, David J. Erle, and Prescott G. Woodruff
P13K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression
Shuai Dong, Bonnie K. Harrington, Eileen Y. Hu, Joseph T. Greene, Amy M. Lehman, Minh Tran, Ronni L. Wasmuth, Meixiao Long, Natarajan Muthusamy, Jennifer R. Brown, Amy J. Johnson, and John C. Byrd
Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
Sungro Jo, Tatiana L. Fonseca, Barbara M. L. C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Anaysa P. Bolin, Rodrigo R. Da Conceição, Joao Pedro Werneck-de-Castro, Daniele L. Ignacio, Péter Egri, Dorottya Németh, Csaba Fekete, Maria Martha Bernardi, Victoria D. Leitch, Naila S. Mannan, Katharine F. Curry, Natalie C. Butterfield, J.H. Duncan Bassett, Graham R. Williams, Balázs Gereben, Miriam O. Ribeiro, and Antonio C. Bianco
Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
Jun Wei, Anantha Marisetty, Brett Schrand, Konrad Gabrusiewicz, Yuuri Hashimoto, Martina Ott, Zacharia Grami, Ling-Yuan Kong, Xiaoyang Ling, Hillary Caruso, Shouhao Zhou, Y. Alan Wang, Gregory N. Fuller, Jason Huse, Eli Gilboa, Nannan Kang, Xingxu Huang, Roel Verhaak, Shulin Li, and Amy B. Heimberger
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity
Chien-Chun Steven Pai, Donald M. Simons, Xiaoqing Lu, Michael Evans, Junnian Wei, Yung-hua Wang, Mingyi Chen, John Huang, Chanhyuk Park, Anthony Chang, Jiaxi Wang, Susan Westmoreland, Christine Beam, Dave Banach, Diana Bowley, Feng Dong, Jane Seagal, Wendy Ritacco, Paul L. Richardson, Soumya Mitra, Grace Lynch, Pete Bousquet, John Mankovich, Gillian Kingsbury, and Lawrence Fong
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
Ming Chen, Jiangwen Zhang, Alice H. Berger, Moussa S. Diolombi, Christopher Ng, Jacqueline Fung, Roderick T. Bronson, Mireia Castillo-Martin, Tin Htwe Thin, Carlos Cordon-Cardo, Robin Plevin, and Pier Paolo Pandolfi
L-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
Robert A. Koeth, Betzabe Rachel Lam-Galvez, Jennifer Kirsop, Zeneng Wang, Bruce S. Levison, Xiaodong Gu, Matthew F. Copeland, David Bartlett, David B. Cody, Hong J. Dai, Miranda K. Culley, Xinmin S. Li, Xiaoming Fu, Yuping Wu, Lin Li, Joseph A. DiDonato, W.H. Wilson Tang, Jose Carlos Garcia-Garcia, and Stanley L. Hazen
An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia
Toshiro Saito, Jihoon Nah, Shin-ichi Oka, Risa Mukai, Yoshiya Monden, Yasuhiro Maejima, Yoshiyuki Ikeda, Sebastiano Sciarretta, Tong Liu, Hong Li, Erdene Baljinnyam, Diego Fraidenraich, Luke Fritzky, Peiyong Zhai, Shizuko Ichinose, Mitsuaki Isobe, Chiao-Po Hsu, Mondira Kundu, and Junichi Sadoshima
Cardiac CaV1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking
Lin Yang, Alexander Katchman, Jared Kushner, Alexander Kushnir, Sergey I. Zakharov, Bi-xing Chen, Zunaira Shuja, Prakash Subramanyam, Guoxia Liu, Arianne Papa, Daniel Roybal, Geoffrey S. Pitt, Henry M. Colecraft, and Steven O. Marx
Rescue of recurrent deep intronic mutation underlying cell type–dependent quantitative NEMO deficiency
Bertrand Boisson, Yoshitaka Honda, Masahiko Ajiro, Jacinta Bustamante, Matthieu Bendavid, Andrew R. Gennery, Yuri Kawasaki, Jose Ichishima, Mitsujiro Osawa, Hiroshi Nihira, Takeshi Shiba, Takayuki Tanaka, Maya Chrabieh, Benedetta Bigio, Hong Hur, Yuval Itan, Yupu Liang, Satoshi Okada, Kazushi Izawa, Ryuta Nishikomori, Osamu Ohara, Toshio Heike, Laurent Abel, Anne Puel, Megumu K. Saito, Jean-Laurent Casanova, Masatoshi Hagiwara, and Takahiro Yasumi
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia
Hongjie Wang, Aphrodite Georgakopoulou, Nikoletta Psatha, Chang Li, Chrysi Capsali, Himanshu Bhusan Samal, Achilles Anagnostopoulos, Anja Ehrhardt, Zsuzsanna Izsvák, Thalia Papayannopoulou, Evangelia Yannaki, and André Lieber
Gene fitness landscape of group A streptococcus during necrotizing myositis
Luchang Zhu, Randall J. Olsen, Stephen B. Beres, Jesus M. Eraso, Matthew Ojeda Saavedra, Samantha L. Kubiak, Concepcion C. Cantu, Leslie Jenkins, Amelia R. L. Charbonneau, Andrew S. Waller, and James M. Musser
HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia
Alejandro A. Pezzulo, Rosarie A. Tudas, Carley G. Stewart, Luis G. Vargas Buonfiglio, Brian D. Lindsay, Peter J. Taft, Nicholas D. Gansemer, and Joseph Zabner
Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
Sahra Bodo, Cécile Campagne, Tin Htwe Thin, Daniel S. Higginson, H. Alberto Vargas, Guoqiang Hua, John D. Fuller, Ellen Ackerstaff, James Russell, Zhigang Zhang, Stefan Klingler, HyungJoon Cho, Matthew G. Kaag, Yousef Mazaheri, Andreas Rimner, Katia Manova-Todorova, Boris Epel, Joan Zatcky, Cristian R. Cleary, Shyam S. Rao, Yoshiya Yamada, Michael J. Zelefsky, Howard J. Halpern, Jason A. Koutcher, Carlos Cordon-Cardo, Carlo Greco, Adriana Haimovitz-Friedman, Evis Sala, Simon N. Powell, Richard Kolesnick, and Zvi Fuks
Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection
Wenjun Li, Jason M. Gauthier, Ryuji Higashikubo, Hsi-Min Hsiao, Satona Tanaka, Linh Vuong, Jon H. Ritter, Alice Y. Tong, Brian W. Wong, Ramsey R. Hachem, Varun Puri, Ankit Bharat, Alexander S. Krupnick, Chyi S. Hsieh, William M. Baldwin III, Francine L. Kelly, Scott M. Palmer, Andrew E. Gelman, and Daniel Kreisel
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
Sam C. Nalle, Li Zuo, Ma. Lora Drizella M. Ong, Gurminder Singh, Alicia M. Worthylake, Wangsun Choi, Mario Cabrero Manresa, Anna P. Southworth, Karen L. Edelblum, Gregory J. Baker, Nora E. Joseph, Peter A. Savage, and Jerrold R. Turner
Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome
Elena Gallo MacFarlane, Sarah J. Parker, Joseph Y. Shin, Shira G. Ziegler, Tyler J. Creamer, Rustam Bagirzadeh, Djahida Bedja, Yichun Chen, Juan F. Calderon, Katherine Weissler, Pamela A. Frischmeyer-Guerrerio, Mark E. Lindsay, Jennifer P. Habashi, and Harry C. Dietz
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy
Kevin B. Einkauf, Guinevere Q. Lee, Ce Gao, Radwa Sharaf, Xiaoming Sun, Stephane Hua, Samantha M.Y. Chen, Chenyang Jiang, Xiaodong Lian, Fatema Z. Chowdhury, Eric S. Rosenberg, Tae-Wook Chun, Jonathan Z. Li, Xu G. Yu, and Mathias Lichterfeld
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
Mattias N.D. Svensson, Karen M. Doody, Benjamin J. Schmiedel, Sourya Bhattacharyya, Bharat Panwar, Florian Wiede, Shen Yang, Eugenio Santelli, Dennis J. Wu, Cristiano Sacchetti, Ravindra Gujar, Gregory Seumois, William B. Kiosses, Isabelle Aubry, Gisen Kim, Piotr Mydel, Shimon Sakaguchi, Mitchell Kronenberg, Tony Tiganis, Michel L. Tremblay, Ferhat Ay, Pandurangan Vijayanand, and Nunzio Bottini
CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen
Shiteng Duan, Cynthia J. Koziol-White, William F. Jester Jr., Corwin M. Nycholat, Matthew S. Macauley, Reynold A. Panettieri Jr., and James C. Paulson
Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
Simona Stivala, Tamara Codilupi, Sime Brkic, Anne Baerenwaldt, Nilabh Ghosh, Hui Hao-Shen, Stephan Dirnhofer, Matthias S. Dettmer, Cedric Simillion, Beat A. Kaufmann, Sophia Chiu, Matthew Keller, Maria Kleppe, Morgane Hilpert, Andreas S. Buser, Jakob R. Passweg, Thomas Radimerski, Radek C. Skoda, Ross L. Levine, and Sara C. Meyer
Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model
Yueqin Zhou, Sharon Carmona, A.K.M.G. Muhammad, Shaughn Bell, Jesse Landeros, Michael Vazquez, Ritchie Ho, Antonietta Franco, Bin Lu, Gerald W. Dorn II, Shaomei Wang, Cathleen M. Lutz, and Robert H. Baloh
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic
Sarah Tomkovich, Christine M. Dejea, Kathryn Winglee, Julia L. Drewes, Liam Chung, Franck Housseau, Jillian L. Pope, Josee Gauthier, Xiaolun Sun, Marcus Mühlbauer, Xiuli Liu, Payam Fathi, Robert A. Anders, Sepideh Besharati, Ernesto Perez-Chanona, Ye Yang, Hua Ding, Xinqun Wu, Shaoguang Wu, James R. White, Raad Z. Gharaibeh, Anthony A. Fodor, Hao Wang, Drew M. Pardoll, Christian Jobin, and Cynthia L. Sears
Follicular lymphoma–associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR
Fangyang Wang, Damián Gatica, Zhang Xiao Ying, Luke F. Peterson, Peter Kim, Denzil Bernard, Kamlai Saiya-Cork, Shaomeng Wang, Mark S. Kaminski, Alfred E. Chang, Tycel Phillips, Daniel J. Klionsky, and Sami N. Malek
Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma
Niraj Shenoy, Tushar D. Bhagat, John Cheville, Christine Lohse, Sanchari Bhattacharyya, Alexander Tischer, Venkata Machha, Shanisha Gordon-Mitchell, Gaurav Choudhary, Li-Fan Wong, LouAnn Gross, Emily Ressigue, Bradley Leibovich, Stephen A. Boorjian, Ulrich Steidl, Xiaosheng Wu, Kith Pradhan, Benjamin Gartrell, Beamon Agarwal, Lance Pagliaro, Masako Suzuki, John M. Greally, Dinesh Rakheja, R. Houston Thompson, Katalin Susztak, Thomas Witzig, Yiyu Zou, and Amit Verma
miR-142 controls metabolic reprogramming that regulates dendritic cell activation
Yaping Sun, Katherine Oravecz-Wilson, Sydney Bridges, Richard McEachin, Julia Wu, Stephanie H. Kim, Austin Taylor, Cynthia Zajac, Hideaki Fujiwara, Daniel Christopher Peltier, Thomas Saunders, and Pavan Reddy
IL-26 contributes to host defense against intracellular bacteria
Angeline Tilly Dang, Rosane M.B. Teles, David I. Weiss, Kislay Parvatiyar, Euzenir N. Sarno, Maria T. Ochoa, Genhong Cheng, Michel Gilliet, Barry R. Bloom, and Robert L. Modlin
Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis
Ting Wen, Bruce J. Aronow, Yrina Rochman, Mark Rochman, Kiran KC, Phil J. Dexheimer, Philip Putnam, Vincent Mukkada, Heather Foote, Kira Rehn, Sam Darko, Daniel Douek, and Marc E. Rothenberg
uPAR isoform 2 forms a dimer and induces severe kidney disease in mice
Changli Wei, Jing Li, Brian D. Adair, Ke Zhu, Jian Cai, Michael Merchant, Beata Samelko, Zhongji Liao, Kwi Hye Koh, Nicholas J. Tardi, Ranadheer R. Dande, Shuangxin Liu, Jianchao Ma, Salvatore Dibartolo, Stefan Hägele, Vasil Peev, Salim S. Hayek, David J. Cimbaluk, Melissa Tracy, Jon Klein, Sanja Sever, Sanford J. Shattil, M. Amin Arnaout, and Jochen Reiser
Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells
Takahiro Kamiya, See Voon Seow, Desmond Wong, Murray Robinson, and Dario Campana
Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor
Gerardo A. Vitiello, Timothy G. Bowler, Mengyuan Liu, Benjamin D. Medina, Jennifer Q. Zhang, Nesteene J. Param, Jennifer K. Loo, Rachel L. Goldfeder, Frederic Chibon, Ferdinand Rossi, Shan Zeng, and Ronald P. DeMatteo
Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival
Patrick Kellish, Daniil Shabashvili, Masmudur M. Rahman, Akbar Nawab, Maria V. Guijarro, Min Zhang, Chunxia Cao, Nissin Moussatche, Theresa Boyle, Scott Antonia, Mary Reinhard, Connor Hartzell, Michael Jantz, Hiren J. Mehta, Grant McFadden, Frederic J. Kaye, and Maria Zajac-Kaye
Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage
Hasina Outtz Reed, Liqing Wang, Jarrod Sonett, Mei Chen, Jisheng Yang, Larry Li, Petra Aradi, Zoltan Jakus, Jeanine D’Armiento, Wayne W. Hancock, and Mark L. Kahn
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
Wenjun Li, Guoshuai Feng, Jason M. Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka, Hsi-Min Hsiao, Daniel Ruiz-Perez, Andrea Bredemeyer, Richard W. Gross, Douglas L. Mann, Yulia Y. Tyurina, Andrew E. Gelman, Valerian E. Kagan, Andreas Linkermann, Kory J. Lavine, and Daniel Kreisel
Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis
Martin D. Burkhalter, Arthi Sridhar, Pedro Sampaio, Raquel Jacinto, Martina S. Burczyk, Cornelia Donow, Max Angenendt, Competence Network for Congenital Heart Defects Investigators, Maja Hempel, Paul Walther, Petra Pennekamp, Heymut Omran, Susana S. Lopes, Stephanie M. Ware, and Melanie Philipp
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking
Jingzhu Zhang, Teerawit Supakorndej, Joseph R. Krambs, Mahil Rao, Grazia Abou-Ezzi, Rachel Y. Ye, Sidan Li, Kathryn Trinkaus, and Daniel C. Link
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
Ajay Abraham, Shaowei Qiu, Balu K. Chacko, Hui Li, Andrew Paterson, Jianbo He, Puneet Agarwal, Mansi Shah, Robert Welner, Victor M. Darley-Usmar, and Ravi Bhatia
Aberrant splicing contributes to severe α-spectrin–linked congenital hemolytic anemia
Patrick G. Gallagher, Yelena Maksimova, Kimberly Lezon-Geyda, Peter E. Newburger, Desiree Medeiros, Robin D. Hanson, Jennifer Rothman, Sara Israels, Donna A. Wall, Robert F. Sidonio Jr., Colin Sieff, L. Kate Gowans, Nupur Mittal, Roland Rivera-Santiago, David W. Speicher, Susan J. Baserga, and Vincent P. Schulz
Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression
Emma E. Hornick, Jargalsaikhan Dagvadorj, Zeb R. Zacharias, Ann M. Miller, Ryan A. Langlois, Peter Chen, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala, and Suzanne L. Cassel
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury
Wei-Zhong Ying, Xingsheng Li, Sunil Rangarajan, Wenguang Feng, Lisa M. Curtis, Paul W. Sanders
Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
Darja Karpova, Michael P. Rettig, Julie Ritchey, Daniel Cancilla, Stephanie Christ, Leah Gehrs, Ezhilarasi Chendamarai, Moses O. Evbuomwan, Matthew Holt, Jingzhu Zhang, Grazia Abou-Ezzi, Hamza Celik, Eliza Wiercinska, Wei Yang, Feng Gao, Linda G. Eissenberg, Richard F. Heier, Stacy D. Arnett, Marvin J. Meyers, Michael J. Prinsen, David W. Griggs, Andreas Trumpp, Peter G. Ruminski, Dwight M. Morrow, Halvard B. Bonig, Daniel C. Link, and John F. DiPersio
CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs
Ross A. Okimoto, Wei Wu, Shigeki Nanjo, Victor Olivas, Yone K. Lin, Rovingaile Kriska Ponce, Rieko Oyama, Tadashi Kondo, and Trever G. Bivona
Residual β cell function and monogenic variants in long-duration type 1 diabetes patients
Marc Gregory Yu, Hillary A. Keenan, Hetal S. Shah, Scott G. Frodsham, David Pober, Zhiheng He, Emily A. Wolfson, Stephanie D’Eon, Liane J. Tinsley, Susan Bonner-Weir, Marcus G. Pezzolesi, and George Liang King
ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes
G. Michelle Ducasa, Alla Mitrofanova, Shamroop K. Mallela, Xiaochen Liu, Judith Molina, Alexis Sloan, Christopher E. Pedigo, Mengyuan Ge, Javier Varona Santos, Yanio Hernandez, Jin-Ju Kim, Cyrille Maugeais, Armando J. Mendez, Viji Nair, Matthias Kretzler, George W. Burke, Robert G. Nelson, Yu Ishimoto, Reiko Inagi, Santanu Banerjee, Shaoyi Liu, Hazel H. Szeto, Sandra Merscher, Flavia Fontanesi, and Alessia Fornoni
Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer
Nithya Sivaram, Patrick A. McLaughlin, Han V. Han, Oleksi Petrenko, Ya-Ping Jiang, Lisa M. Ballou, Kien Pham, Chen Liu, Adrianus W.M. van der Velden, and Richard Z. Lin
PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice
Ismail Syed, Maria F. Rubin de Celis, James F. Mohan, Pedro M. Moraes-Vieira, Archana Vijayakumar, Andrew T. Nelson, Dionicio Siegel, Alan Saghatelian, Diane Mathis, and Barbara B. Kahn
Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development
Pedro H. Gazzinelli-Guimaraes, Rafael de Queiroz Prado, Alessandra Ricciardi, Sandra Bonne-Année, Joshua Sciurba, Erik P. Karmele, Ricardo T. Fujiwara, and Thomas B. Nutman
Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infections
John I. Robinson, William H. Weir, Jan R. Crowley, Tiffany Hink, Kimberly A. Reske, Jennie H. Kwon, Carey-Ann D. Burnham, Erik R. Dubberke, Peter J. Mucha, and Jeffrey P. Henderson
Human VP8* mAbs neutralize rotavirus selectively in human intestinal epithelial cells
Ningguo Feng, Liya Hu, Siyuan Ding, Mrinmoy Sanyal, Boyang Zhao, Banumathi Sankaran, Sasirekha Ramani, Monica McNeal, Linda L. Yasukawa, Yanhua Song, B.V. Venkataram Prasad, and Harry B. Greenberg
Dectin-2–induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis
Chie Miyabe, Yoshishige Miyabe, Laura Bricio-Moreno, Jeffrey Lian, Rod A. Rahimi, Noriko N. Miura, Naohito Ohno, Yoichiro Iwakura, Tamihiro Kawakami, and Andrew D. Luster
LEAP2 changes with body mass and food intake in humans and mice
Bharath K. Mani, Nancy Puzziferri, Zhenyan He, Juan A. Rodriguez, Sherri Osborne-Lawrence, Nathan P. Metzger, Navpreet Chhina, Bruce Gaylinn, Michael O. Thorner, E. Louise Thomas, Jimmy D. Bell, Kevin W. Williams, Anthony P. Goldstone, and Jeffrey M. Zigman
Tumor cell–intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2)
Nune Markosyan, Jinyang Li, Yu H. Sun, Lee P. Richman, Jeffrey H. Lin, Fangxue Yan, Liz Quinones, Yogev Sela, Taiji Yamazoe, Naomi Gordon, John W. Tobias, Katelyn T. Byrne, Andrew J. Rech, Garret A. FitzGerald, Ben Z. Stanger, and Robert H. Vonderheide
Antibodies targeting sialyl Lewis A mediate tumor clearance through distinct effector pathways
Polina Weitzenfeld, Stylianos Bournazos, and Jeffrey V. Ravetch
mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes
Rami Jaafar, Stella Tran, Ajit N. Shah, Gao Sun, Martin Valdearcos, Piero Marchetti, Matilde Masini, Avital Swisa, Simone Giacometti, Ernesto Bernal-Mizrachi, Aleksey Matveyenko, Matthias Hebrok, Yuval Dor, Guy A. Rutter, Suneil K. Koliwad, and Anil Bhushan
PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms
Peng Zhou, Anna Santoro, Odile D. Peroni, Andrew T. Nelson, Alan Saghatelian, Dionicio Siegel, and Barbara B. Kahn
Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223
Carolina Jimenez Calvente, Masahiko Tameda, Casey D. Johnson, Hana del Pilar, Yun Chin Lin, Nektaria Adronikou, Xavier De Mollerat Du Jeu, Cristina Llorente, Josh Boyer, and Ariel E. Feldstein
Potential role of iron in repair of inflammatory demyelinating lesions
Nathanael J. Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Govind Nair, Nicholas J. Luciano, Emily C. Leibovitch, Cecil C. Yen, Tracey A. Rouault, Afonso C. Silva, Steven Jacobson, and Daniel S. Reich
Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, and Lei Liu
Immune overdrive signature in colorectal tumor subset predicts poor clinical outcome
Marwan Fakih, Ching Ouyang, Chongkai Wang, Travis Yiwey Tu, Maricel C. Gozo, May Cho, Marvin Sy, Jeffrey A. Longmate, and Peter P. Lee
IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
Gang Chen, Ling Sun, Takafumi Kato, Kenichi Okuda, Mary B. Martino, Aiman Abzhanova, Jennifer M. Lin, Rodney C. Gilmore, Bethany D. Batson, Yvonne K. O’Neal, Allison S. Volmer, Hong Dang, Yangmei Deng, Scott H. Randell, Brian Button, Alessandra Livraghi-Butrico, Mehmet Kesimer, Carla M.P. Ribeiro, Wanda K. O’Neal, and Richard C. Boucher
Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Matthew C. Madison, Cameron T. Landers, Bon-Hee Gu, Cheng-Yen Chang, Hui-Ying Tung, Ran You, Monica J. Hong, Nima Baghaei, Li-Zhen Song, Paul Porter, Nagireddy Putluri, Ramiro Salas, Brian E. Gilbert, Ilya Levental, Matthew J. Campen, David B. Corry, and Farrah Kheradmand
Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
Brigitte Laforest, Wenli Dai, Leonid Tyan, Sonja Lazarevic, Kaitlyn M. Shen, Margaret Gadek, Michael T. Broman, Christopher R. Weber, and Ivan P. Moskowitz
Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment
Daniel M. Ramos, Constantin d’Ydewalle, Vijayalakshmi Gabbeta, Amal Dakka, Stephanie K. Klein, Daniel A. Norris, John Matson, Shannon J. Taylor, Phillip G. Zaworski, Thomas W. Prior, Pamela J. Snyder, David Valdivia, Christine L. Hatem, Ian Waters, Nikhil Gupte, Kathryn J. Swoboda, Frank Rigo, C. Frank Bennett, Nikolai Naryshkin, Sergey Paushkin, Thomas O. Crawford, and Charlotte J. Sumner
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma
Paul C. Moore, Jessica T. Cortez, Chester E. Chamberlain, Diana Alba, Amy C. Berger, Zoe Quandt, Alice Chan, Mickie H. Cheng, Jhoanne L. Bautista, Justin Peng, Michael S. German, Mark S. Anderson, and Scott A. Oakes
Increased flux through the mevalonate pathway mediates fibrotic repair without injury
Jennifer L. Larson-Casey, Mudit Vaid, Linlin Gu, Chao He, Guo-Qiang Cai, Qiang Ding, Dana Davis, Taylor F. Berryhill, Landon S. Wilson, Stephen Barnes, Jeffrey D. Neighbors, Raymond J. Hohl, Kurt A. Zimmerman, Bradley K. Yoder, Ana Leda F. Longhini, Vidya Sagar Hanumanthu, Ranu Surolia, Veena B. Antony, and A. Brent Carter
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation
W. Brian Dalton, Eric Helmenstine, Noel Walsh, Lukasz P. Gondek, Dhanashree S. Kelkar, Abigail Read, Rachael Natrajan, Eric S. Christenson, Barbara Roman, Samarjit Das, Liang Zhao, Robert D. Leone, Daniel Shinn, Taylor Groginski, Anil K. Madugundu, Arun Patil, Daniel J. Zabransky, Arielle Medford, Justin Lee, Alex J. Cole, Marc Rosen, Maya Thakar, Alexander Ambinder, Joshua Donaldson, Amy E. DeZern, Karen Cravero, David Chu, Rafael Madero-Marroquin, Akhilesh Pandey, Paula J. Hurley, Josh Lauring, and Ben Ho Park
Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis
Ji-Yeon Shin, Antonio Hernandez-Ono, Tatyana Fedotova, Cecilia Östlund, Michael J. Lee, Sarah B. Gibeley, Chun-Chi Liang, William T. Dauer, Henry N. Ginsberg, and Howard J. Worman
Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans
Kitt Falk Petersen, Sylvie Dufour, Gary W. Cline, and Gerald I. Shulman
Recombinant annexin A6 promotes membrane repair and protects against muscle injury
Alexis R. Demonbreun, Katherine S. Fallon, Claire C. Oosterbaan, Elena Bogdanovic, James L. Warner, Jordan J. Sell, Patrick G. Page, Mattia Quattrocelli, David Y. Barefield, and Elizabeth M. McNally
Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses
Seiji Kishi, Craig R. Brooks, Kensei Taguchi, Takaharu Ichimura, Yutaro Mori, Akinwande Akinfolarin, Navin Gupta, Pierre Galichon, Bertha C. Elias, Tomohisa Suzuki, Qian Wang, Leslie Gewin, Ryuji Morizane, and Joseph V. Bonventre
High-fat diet exacerbates SIV pathogenesis and accelerates disease progression
Tianyu He, Cuiling Xu, Noah Krampe, Stephanie M. Dillon, Paola Sette, Elizabeth Falwell, George S. Haret-Richter, Tiffany Butterfield, Tammy L. Dunsmore, William M. McFadden Jr., Kathryn J. Martin, Benjamin B. Policicchio, Kevin D. Raehtz, Ellen P. Penn, Russell P. Tracy, Ruy M. Ribeiro, Daniel N. Frank, Cara C. Wilson, Alan L. Landay, Cristian Apetrei, and Ivona Pandrea
Slowing ribosome velocity restores folding and function of mutant CFTR
Kathryn E. Oliver, Robert Rauscher, Marjolein Mijnders, Wei Wang, Matthew J. Wolpert, Jessica Maya, Carleen M. Sabusap, Robert A. Kesterson, Kevin L. Kirk, Andras Rab, Ineke Braakman, Jeong S. Hong, John L. Hartman IV, Zoya Ignatova, and Eric J. Sorscher
Expression of mitochondrial membrane–linked SAB determines severity of sex-dependent acute liver injury
Sanda Win, Robert W.M. Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, Manal F. Abdelmalek, Ying Wang, Mariam Aghajan, Filbert W.M. Aung, Anna Mae Diehl, Roger J. Davis, Tin A. Than, and Neil Kaplowitz
FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury
Monica Chang-Panesso, Farid F. Kadyrov, Matthew Lalli, Haojia Wu, Shiyo Ikeda, Eirini Kefaloyianni, Mai M. Abdelmageed, Andreas Herrlich, Akio Kobayashi, and Benjamin D. Humphreys
Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment
Amy J. Petty, Ang Li, Xinyi Wang, Rui Dai, Benjamin Heyman, David Hsu, Xiaopei Huang, and Yiping Yang
Hemodynamic regulation of perivalvular endothelial gene expression prevents deep thrombosis
John D. Welsh, Mark H. Hoofnagle, Sharika Bamezai, Michael Oxendine, Lillian Lim, Joshua D. Hall, Jisheng Yang, Susan Schultz, James Douglas Engel, Tsutomu Kume, Guillermo Oliver, Juan M. Jimenez, and Mark L. Kahn