Maya Hoptman

JCI Editor’s update, January 2021

Posted on by Maya Hoptman

Dear Colleague,

As the year 2021 begins, I would like to take the opportunity to update you on recent JCI activity. The Journal continues to build on its history of publishing outstanding biomedical research that garners wide attention (highlighted below my signature).

The COVID-19 pandemic affected the JCI’s operations in many ways:

  • Due to the pandemic’s disruption of research activities, the editorial board instituted new policies to streamline the review and decision processes, and to allow authors enough time to complete additional experiments requested by reviewers (see the related editorial).
  • The number of research submissions increased by almost 25% in 2020 compared with 2019.
  • Among a total of 424 research articles, the JCI published 19 on COVID-19.

In the Clinical Medicine (CMED) category, now in its eighth year, the JCI continues to welcome submissions reporting diagnostic advances, new medical therapies and interventions, and observational studies that have the potential to improve medical practice and health outcomes. In 2020, the JCI published 57 CMED articles, including:

JCI Viewpoint articles have showcased experts and thought leaders in medicine, academia, nonprofit organizations, and industry, and representatives of the JCI and the ASCI on subjects of topical and long-term interest to scientists and society at large. In January, the Journal published a series of Viewpoints on the effects of climate change on human health. A July Viewpoint, Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists, attracted nearly 16,000 views. Other Viewpoint articles have dealt with COVID-19; translational medicine; the effects of vaping; marijuana use in pregnancy; alternative medicine; and racism, diversity, and health equity. Watch for a Viewpoint series on team science to be published early this year.

The Journal published four Review Series, edited by members of our board:

Individual Reviews covered a range of subjects, from COVID-19 to gene therapy to metabolism.

Reminders:

  • ASCI members who are the corresponding author of a first-round submission to the JCI, and whose dues are current, may designate one submission per calendar year to be guaranteed for external peer review. For details, visit the JCI Information for Authors page.
  • Authors may transfer manuscripts from the preprint server bioRxiv and medRxiv for submission to the JCI.

I wish you a happy and productive New Year, and look forward to reading your best work.

Sincerely,

Rexford S. Ahima, MD, PhD
Editor, The Journal of Clinical Investigation

 

Corresponding authors who are ASCI members are indicated in bold.

Top-viewed JCI articles, 2020

Source: Google Analytics, December 29, 2020

The convalescent sera option for containing COVID-19
Viewpoint
Arturo Casadevall and Liise-anne Pirofski

Times viewed: 172,437

Clinical and immunological features of severe and moderate coronavirus disease 2019
Clinical Medicine
Guang Chen, Di Wu, Wei Guo, Yong Cao, Da Huang, Hongwu Wang, Tao Wang, Xiaoyun Zhang, Huilong Chen, Haijing Yu, Xiaoping Zhang, Minxia Zhang, Shiji Wu, Jianxin Song, Tao Chen, Meifang Han, Shusheng Li, Xiaoping Luo, Jianping Zhao, and Qin Ning

Times viewed: 48,645

Deployment of convalescent plasma for the prevention and treatment of COVID-19
Review
Evan M. Bloch, Shmuel Shoham, Arturo Casadevall, Bruce S. Sachais, Beth Shaz, Jeffrey L. Winters, Camille van Buskirk, Brenda J. Grossman, Michael Joyner, Jeffrey P. Henderson, Andrew Pekosz, Bryan Lau, Amy Wesolowski, Louis Katz, Hua Shan, Paul G. Auwaerter, David Thomas, David J. Sullivan, Nigel Paneth, Eric Gehrie, Steven Spitalnik, Eldad A. Hod, Lewis Pollack, Wayne T. Nicholson, Liise-anne Pirofski, Jeffrey A. Bailey, and Aaron A.R. Tobian

Times viewed: 45,365

SARS-CoV-2: a storm is raging
Commentary
Savannah F. Pedersen and Ya-Chi Ho

Times viewed: 44,426

Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists
Viewpoint
Maximilian F. Konig, Mike Powell, Verena Staedtke, Ren-Yuan Bai, David L. Thomas, Nicole Fischer, Sakibul Huq, Adham M. Khalafallah, Allison Koenecke, Ruoxuan Xiong, Brett Mensh, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Joshua T. Vogelstein, Susan Athey, Shibin Zhou, and Chetan Bettegowda

Times viewed: 15,768

Recent endemic coronavirus infection is associated with less-severe COVID-19
Concise Communication
Manish Sagar, Katherine Reifler, Michael Rossi, Nancy S. Miller, Pranay Sinha, Laura F. White, and Joseph P. Mizgerd

Times viewed: 14,447

Kinetics of viral load and antibody response in relation to COVID-19 severity
Research
Yanqun Wang, Lu Zhang, Ling Sang, Feng Ye, Shicong Ruan, Bei Zhong, Tie Song, Abeer N. Alshukairi, Rongchang Chen, Zhaoyong Zhang, Mian Gan, Airu Zhu, Yongbo Huang, Ling Luo, Chris Ka Pun Mok, Manal M. Al Gethamy, Haitao Tan, Zhengtu Li, Xiaofang Huang, Fang Li, Jing Sun, Yanjun Zhang, Liyan Wen, Yuming Li, Zhao Chen, Zhen Zhuang, Jianfen Zhuo, Chunke Chen, Lijun Kuang, Junxiang Wang, Huibin Lv, Yongliang Jiang, Min Li, Yimin Lin, Ying Deng, Lan Tang, Jieling Liang, Jicheng Huang, Stanley Perlman, Nanshan Zhong, Jingxian Zhao, J.S. Malik Peiris, Yimin Li, and Jincun Zhao

Times viewed: 10,647

The COVID-19 pandemic and research shutdown: staying safe and productive
Viewpoint
M. Bishr Omary, Jeetendra Eswaraka, S. David Kimball, Prabhas V. Moghe, Reynold A. Panettieri Jr., and Kathleen W. Scotto

Times viewed: 9,887

Early safety indicators of COVID-19 convalescent plasma in 5000 patients
Clinical Medicine
Michael J. Joyner, R. Scott Wright, DeLisa Fairweather, Jonathon W. Senefeld, Katelyn A. Bruno, Stephen A. Klassen, Rickey E. Carter, Allan M. Klompas, Chad C. Wiggins, John R.A. Shepherd, Robert F. Rea, Emily R. Whelan, Andrew J. Clayburn, Matthew R. Spiegel, Patrick W. Johnson, Elizabeth R. Lesser, Sarah E. Baker, Kathryn F. Larson, Juan G. Ripoll, Kylie J. Andersen, David O. Hodge, Katie L. Kunze, Matthew R. Buras, Matthew N.P. Vogt, Vitaly Herasevich, Joshua J. Dennis, Riley J. Regimbal, Philippe R. Bauer, Janis E. Blair, Camille M. Van Buskirk, Jeffrey L. Winters, James R. Stubbs, Nigel S. Paneth, Nicole C. Verdun, Peter Marks, and Arturo Casadevall

Times viewed: 8,344

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Research
Ethan R. Roy, Baiping Wang, Ying-wooi Wan, Gabriel Chiu, Allysa Cole, Zhuoran Yin, Nicholas E. Propson, Yin Xu, Joanna L. Jankowsky, Zhandong Liu, Virginia M.-Y. Lee, John Q. Trojanowski, Stephen D. Ginsberg, Oleg Butovsky, Hui Zheng, and Wei Cao1

Times viewed: 7,771

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2
Clinical Medicine
Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, and Hamid Bassiri

Times viewed: 6,962

 

The JCI in selected news outlets, 2020

Source: Altmetric, December 29, 2020

Early safety indicators of COVID-19 convalescent plasma in 5000 patients
Clinical Medicine

Mentioned in Popular Science

Clinical and immunological features of severe and moderate coronavirus disease 2019
Clinical Medicine

Mentioned in National Geographic; by National Public Radio (NPR)

BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of healthcare workers
Clinical Medicine
Magali Noval Rivas, Joseph E. Ebinger, Min Wu, Nancy Sun, Jonathan Braun, Kimia Sobhani, Jennifer E. Van Eyk, Susan Cheng, and Moshe Arditi

Mentioned in National Geographic, Popular Science

Residual endotoxin induces primary graft dysfunction through ischemia/reperfusion-primed alveolar macrophages
Research
Mahzad Akbarpour, Emilia Lecuona, Stephen F. Chiu, Qiang Wu, Melissa Querrey, Ramiro Fernandez, Félix L. Núñez-Santana, Haiying Sun, Sowmya Ravi, Chitaru Kurihara, James M. Walter, Nikita Joshi, Ziyou Ren, Scott C. Roberts, Alan Hauser, Daniel Kreisel, Wenjun Li, Navdeep S. Chandel, Alexander V. Misharin, Thalachallour Mohanakumar, G.R. Scott Budinger, and Ankit Bharat

Mentioned by CNN

The glucocorticoid receptor–FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder
Research
Haiyin Li, Ping Su, Terence K.Y. Lai, Anlong Jiang, Jing Liu, Dongxu Zhai, Charlie T.G. Campbell, Frankie H.F. Lee, WeiDong Yong, Suvercha Pasricha, Shupeng Li, Albert H.C. Wong, Kerry J. Ressler, and Fang Liu

Mentioned in Psychology Today

Genome-wide plasma DNA methylation features of metastatic prostate cancer
Research
Anjui Wu, Paolo Cremaschi, Daniel Wetterskog, Vincenza Conteduca, Gian Marco Franceschini, Dimitrios Kleftogiannis, Anuradha Jayaram, Shahneen Sandhu, Stephen Q. Wong, Matteo Benelli, Samanta Salvi, Giorgia Gurioli, Andrew Feber, Mariana Buongermino Pereira, Anna Maria Wingate, Enrique Gonzalez-Billalebeitia, Ugo De Giorgi, Francesca Demichelis, Stefano Lise, and Gerhardt Attard

Mentioned in the Daily Mail (United Kingdom)

Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities
Clinical Medicine
Chiara F. Magnani, Giuseppe Gaipa, Federico Lussana, Daniela Belotti, Giuseppe Gritti, Sara Napolitano, Giada Matera, Benedetta Cabiati, Chiara Buracchi, Gianmaria Borleri, Grazia Fazio, Silvia Zaninelli, Sarah Tettamanti, Stefania Cesana, Valentina Colombo, Michele Quaroni, Giovanni Cazzaniga, Attilio Rovelli, Ettore Biagi, Stefania Galimberti, Andrea Calabria, Fabrizio Benedicenti, Eugenio Montini, Silvia Ferrari, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, and Andrea Biondi

Mentioned in La Repubblica (Italy)

Climate change brings the specter of new infectious diseases
Viewpoint
Arturo Casadevall

Mentioned in Scientific American, Newsweek

 

Social media activity: Twitter

Source: Altmetric, December 29, 2020

Clinical and immunological features of severe and moderate coronavirus disease 2019
Clinical Medicine

Twitter mentions: 3,826

The convalescent sera option for containing COVID-19
Viewpoint

Twitter mentions: 2,643

SARS-CoV-2: a storm is raging
Commentary

Twitter mentions: 2,564

Recent endemic coronavirus infection is associated with less-severe COVID-19
Concise Communication

Twitter mentions: 1,088

Metabolic effects of air pollution exposure and reversibility
Concise Communication
Sanjay Rajagopalan, Bongsoo Park, Rengasamy Palanivel, Vinesh Vinayachandran, Jeffrey A. Deiuliis, Roopesh Singh Gangwar, Lopa Das, Jinhu Yin, Youngshim Choi, Sadeer Al-Kindi, Mukesh K. Jain, Kasper D. Hansen, and Shyam Biswal

Twitter mentions: 569

Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations
Research
Alexandra H. Mandarano, Jessica Maya, Ludovic Giloteaux, Daniel L. Peterson, Marco Maynard, C. Gunnar Gottschalk, and Maureen R. Hanson

Twitter mentions: 464

COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain
Clinical Medicine
Massimiliano Secchi, Elena Bazzigaluppi, Cristina Brigatti, Ilaria Marzinotto, Cristina Tresoldi, Patrizia Rovere-Querini, Andrea Poli, Antonella Castagna, Gabriella Scarlatti, Alberto Zangrillo, Fabio Ciceri, Lorenzo Piemonti, and Vito Lampasona

Twitter mentions: 349

 

Articles with ASCI members as corresponding authors in 2020

Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace
Research
Wan-Chi Lin, Kymberly M. Gowdy, Jennifer H. Madenspacher, Rachel L. Zemans, Kazuko Yamamoto, Miranda Lyons-Cohen, Hideki Nakano, Kyathanahalli Janardhan, Carmen J. Williams, Donald N. Cook, Joseph P. Mizgerd, and Michael B. Fessler
Increased expression of anion transporter SLC26A9 delays diabetes onset in cystic fibrosis
Research
Anh-Thu N. Lam, Melis A. Aksit, Briana Vecchio-Pagan, Celeste A. Shelton, Derek L. Osorio, Arianna F. Anzmann, Loyal A. Goff, David C. Whitcomb, Scott M. Blackman, and Garry R. Cutting
Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling
Research
Heather A. Himburg, Martina Roos, Tiancheng Fang, Yurun Zhang, Christina M. Termini, Lauren Schlussel, Mindy Kim, Amara Pang, Jenny Kan, Liman Zhao, Hyung Suh, Joshua P. Sasine, Gopal Sapparapu, Peter M. Bowers, Gary Schiller, and John P. Chute
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
Research
Andrew D. Hughes, Daqiang Zhao, Hehua Dai, Khodor I. Abou-Daya, Roger Tieu, Rayan Rammal, Amanda L. Williams, Douglas P. Landsittel, Warren D. Shlomchik, Adrian E. Morelli, Martin H. Oberbarnscheidt, and Fadi G. Lakkis
Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome
Research
Caitlin J. Bowen, Juan Francisco Calderón Giadrosic, Zachary Burger, Graham Rykiel, Elaine C. Davis, Mark R. Helmers, Kelly Benke, Elena Gallo MacFarlane, and Harry C. Dietz
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes
Research
Lauren K. Meyer, Benjamin J. Huang, Cristina Delgado-Martin, Ritu P. Roy, Aaron Hechmer, Anica M. Wandler, Tiffaney L. Vincent, Paolo Fortina, Adam B. Olshen, Brent L. Wood, Terzah M. Horton, Kevin M. Shannon, David T. Teachey, and Michelle L. Hermiston
Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes
Concise Communication
Jennie G. Ono, Benjamin I. Kim, Yize Zhao, Paul J. Christos, Yohannes Tesfaigzi, Tilla S. Worgall, and Stefan Worgall
GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein
Research
Jing Cheng, Linda R. Klei, Nathaniel E. Hubel, Ming Zhang, Rebekka Schairer, Lisa M. Maurer, Hanna B. Klei, Heejae Kang, Vincent J. Concel, Phillip C. Delekta, Eric V. Dang, Michelle A. Mintz, Mathijs Baens, Jason G. Cyster, Narayanan Parameswaran, Margot Thome, Peter C. Lucas, and Linda M. McAllister-Lucas
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
Clinical Medicine
Gordon I. Smith, Mahalakshmi Shankaran, Mihoko Yoshino, George G. Schweitzer, Maria Chondronikola, Joseph W. Beals, Adewole L. Okunade, Bruce W. Patterson, Edna Nyangau, Tyler Field, Claude B. Sirlin, Saswata Talukdar, Marc K. Hellerstein, and Samuel Klein
Chikungunya virus replication in skeletal muscle cells is required for disease development
Research
Anthony J. Lentscher, Mary K. McCarthy, Nicholas A. May, Bennett J. Davenport, Stephanie A. Montgomery, Krishnan Raghunathan, Nicole McAllister, Laurie A. Silva, Thomas E. Morrison, and Terence S. Dermody
Staphylococcus aureus toxin suppresses antigen-specific T cell responses
Concise Communication
Brandon Lee, Reuben Olaniyi, Jakub M. Kwiecinski, and Juliane Bubeck Wardenburg
Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy
Concise Communication
Jeremy M. Sullivan, William W. Motley, Janel O. Johnson, William H. Aisenberg, Katherine L. Marshall, Katy E.S. Barwick, Lingling Kong, Jennifer S. Huh, Pamela C. Saavedra-Rivera, Meriel M. McEntagart, Marie-Helene Marion, Lucy A. Hicklin, Hamid Modarres, Emma L. Baple, Mohamed H. Farah, Aamir R. Zuberi, Cathleen M. Lutz, Rachelle Gaudet, Bryan J. Traynor, Andrew H. Crosby, and Charlotte J. Sumner
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
Clinical Medicine
Adriana A. de Jesus, Yangfeng Hou, Stephen Brooks, Louise Malle, Angelique Biancotto, Yan Huang, Katherine R. Calvo, Bernadette Marrero, Susan Moir, Andrew J. Oler, Zuoming Deng, Gina A. Montealegre Sanchez, Amina Ahmed, Eric Allenspach, Bita Arabshahi, Edward Behrens, Susanne Benseler, Liliana Bezrodnik, Sharon Bout-Tabaku, AnneMarie C. Brescia, Diane Brown, Jon M. Burnham, Maria Soledad Caldirola, Ruy Carrasco, Alice Y. Chan, Rolando Cimaz, Paul Dancey, Jason Dare, Marietta DeGuzman, Victoria Dimitriades, Ian Ferguson, Polly Ferguson, Laura Finn, Marco Gattorno, Alexei A. Grom, Eric P. Hanson, Philip J. Hashkes, Christian M. Hedrich, Ronit Herzog, Gerd Horneff, Rita Jerath, Elizabeth Kessler, Hanna Kim, Daniel J. Kingsbury, Ronald M. Laxer, Pui Y. Lee, Min Ae Lee-Kirsch, Laura Lewandowski, Suzanne Li, Vibke Lilleby, Vafa Mammadova, Lakshmi N. Moorthy, Gulnara Nasrullayeva, Kathleen M. O’Neil, Karen Onel, Seza Ozen, Nancy Pan, Pascal Pillet, Daniela G.P. Piotto, Marilynn G. Punaro, Andreas Reiff, Adam Reinhardt, Lisa G. Rider, Rafael Rivas-Chacon, Tova Ronis, Angela Rösen-Wolff, Johannes Roth, Natasha Mckerran Ruth, Marite Rygg, Heinrike Schmeling, Grant Schulert, Christiaan Scott, Gisella Seminario, Andrew Shulman, Vidya Sivaraman, Mary Beth Son, Yuriy Stepanovskiy, Elizabeth Stringer, Sara Taber, Maria Teresa Terreri, Cynthia Tifft, Troy Torgerson, Laura Tosi, Annet Van Royen-Kerkhof, Theresa Wampler Muskardin, Scott W. Canna, and Raphaela Goldbach-Mansky
An endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability
Research
Oakleigh M. Folkes, Rita Báldi, Veronika Kondev, David J. Marcus, Nolan D. Hartley, Brandon D. Turner, Jade K. Ayers, Jordan J. Baechle, Maya P. Misra, Megan Altemus, Carrie A. Grueter, Brad A. Grueter, and Sachin Patel
Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis
Research
Liming Mao, Atsushi Kitani, Eitaro Hiejima, Kim Montgomery-Recht, Wenchang Zhou, Ivan Fuss, Adrian Wiestner, and Warren Strober
Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2
Concise Communication
Ritika Dutta, Tian Yi Zhang, Thomas Köhnke, Daniel Thomas, Miles Linde, Eric Gars, Melissa Stafford, Satinder Kaur, Yusuke Nakauchi, Raymond Yin, Armon Azizi, Anupama Narla, and Ravindra Majeti
Parathyroid hormone–dependent bone formation requires butyrate production by intestinal microbiota
Research
Jau-Yi Li, Mingcan Yu, Subhashis Pal, Abdul Malik Tyagi, Hamid Dar, Jonathan Adams, M. Neale Weitzmann, Rheinallt M. Jones, and Roberto Pacifici
Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease
Research
Joshua N. Curry, Matthew Saurette, Masomeh Askari, Lei Pei, Michael B. Filla, Megan R. Beggs, Peter S.N. Rowe, Timothy Fields, Andre J. Sommer, Chizu Tanikawa, Yoichiro Kamatani, Andrew P. Evan, Mehdi Totonchi, R. Todd Alexander, Koichi Matsuda, and Alan S.L. Yu
Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation
Research
Guadalupe Ortiz-Muñoz, Michelle A. Yu, Emma Lefrançais, Beñat Mallavia, Colin Valet, Jennifer J. Tian, Serena Ranucci, Kristin M. Wang, Zhe Liu, Nicholas Kwaan, Diana Dawson, Mary Ellen Kleinhenz, Fadi T. Khasawneh, Peter M. Haggie, Alan S. Verkman, and Mark R. Looney
Leptin mediates postprandial increases in body temperature through hypothalamus–adrenal medulla–adipose tissue crosstalk
Research
Rachel J. Perry, Kun Lyu, Aviva Rabin-Court, Jianying Dong, Xiruo Li, Yunfan Yang, Hua Qing, Andrew Wang, Xiaoyong Yang, and Gerald I. Shulman
Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis
Research
Jeongeun Hyun, Zhaoli Sun, Ali Reza Ahmadi, Sushant Bangru, Ullas V. Chembazhi, Kuo Du, Tianyi Chen, Hidekazu Tsukamoto, Ivan Rusyn, Auinash Kalsotra, and Anna Mae Diehl
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
Clinical Medicine
Alana E. O’Mara, James W. Johnson, Joyce D. Linderman, Robert J. Brychta, Suzanne McGehee, Laura A. Fletcher, Yael A. Fink, Devika Kapuria, Thomas M. Cassimatis, Nathan Kelsey, Cheryl Cero, Zahraa Abdul Sater, Francesca Piccinini, Alison S. Baskin, Brooks P. Leitner, Hongyi Cai, Corina M. Millo, William Dieckmann, Mary Walter, Norman B. Javitt, Yaron Rotman, Peter J. Walter, Marilyn Ader, Richard N. Bergman, Peter Herscovitch, Kong Y. Chen, and Aaron M. Cypess
The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans
Clinical Medicine
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, and Philip A. Kern
Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion
Clinical Medicine
Richard O. Francis, Angelo D’Alessandro, Andrew Eisenberger, Mark Soffing, Randy Yeh, Esther Coronel, Arif Sheikh, Francesca Rapido, Francesca La Carpia, Julie A. Reisz, Sarah Gehrke, Travis Nemkov, Tiffany Thomas, Joseph Schwartz, Chaitanya Divgi, Debra Kessler, Beth H. Shaz, Yelena Ginzburg, James C. Zimring, Steven L. Spitalnik, and Eldad A. Hod
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood
Research
Olivia Weeks, Gabriel D. Bossé, Isaac M. Oderberg, Sebastian Akle, Yariv Houvras, Paul J. Wrighton, Kyle LaBella, Isabelle Iversen, Sahar Tavakoli, Isaac Adatto, Arkadi Schwartz, Daan Kloosterman, Allison Tsomides, Michael E. Charness, Randall T. Peterson, Matthew L. Steinhauser, Pouneh K. Fazeli, and Wolfram Goessling
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice
Research
Dario F. De Jesus, Kazuki Orime, Dorota Kaminska, Tomohiko Kimura, Giorgio Basile, Chih-Hao Wang, Larissa Haertle, Renzo Riemens, Natalie K. Brown, Jiang Hu, Ville Männistö, Amélia M. Silva, Ercument Dirice, Yu-Hua Tseng, Thomas Haaf, Jussi Pihlajamäki, and Rohit N. Kulkarni
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation
Research
Sandip M. Swain, Joelle M.-J. Romac, Rafiq A. Shahid, Stephen J. Pandol, Wolfgang Liedtke, Steven R. Vigna, and Rodger A. Liddle
BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo
Research
Yanqin Ren, Szu Han Huang, Shabnum Patel, Winiffer D. Conce Alberto, Dean Magat, Dughan Ahimovic, Amanda B. Macedo, Ryan Durga, Dora Chan, Elizabeth Zale, Talia M. Mota, Ronald Truong, Thomas Rohwetter, Chase D. McCann, Colin M. Kovacs, Erika Benko, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Alberto Bosque, Catherine M. Bollard, and R. Brad Jones
Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure
Research
Wei Zou, Nidhi Rohatgi, Jonathan R. Brestoff, John R. Moley, Yongjia Li, Jesse W. Williams, Yael Alippe, Hua Pan, Terri A. Pietka, Gabriel Mbalaviele, Elizabeth P. Newberry, Nicholas O. Davidson, Anwesha Dey, Kooresh I. Shoghi, Richard D. Head, Samuel A. Wickline, Gwendalyn J. Randolph, Nada A. Abumrad, and Steven L. Teitelbaum
Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis
Concise Communication
Bomi Lee, Julia Z. Adamska, Hong Namkoong, Melena D. Bellin, Josh Wilhelm, Gregory L. Szot, David M. Louis, Mark M. Davis, Stephen J. Pandol, and Aida Habtezion
Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin
Research
Jonathan N. Flak, Paulette B. Goforth, James Dell’Orco, Paul V. Sabatini, Chien Li, Nadejda Bozadjieva, Matthew Sorensen, Alec Valenta, Alan Rupp, Alison H. Affinati, Corentin Cras-Méneur, Ahsan Ansari, Jamie Sacksner, Nandan Kodur, Darleen A. Sandoval, Robert T. Kennedy, David P. Olson, and Martin G. Myers Jr.
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury
Research
Jihoon Nah, Peiyong Zhai, Chun-Yang Huang, Álvaro F. Fernández, Satvik Mareedu, Beth Levine, and Junichi Sadoshima
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling
Research
Austin Hsu, Qiming Duan, Sarah McMahon, Yu Huang, Sarah A.B. Wood, Nathanael S. Gray, Biao Wang, Benoit G. Bruneau, and Saptarsi M. Haldar
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer
Research
Manjie Xing, Wen Fong Ooi, Jing Tan, Aditi Qamra, Po-Hsien Lee, Zhimei Li, Chang Xu, Nisha Padmanabhan, Jing Quan Lim, Yu Amanda Guo, Xiaosai Yao, Mandoli Amit, Ley Moy Ng, Taotao Sheng, Jing Wang, Kie Kyon Huang, Chukwuemeka George Anene-Nzelu, Shamaine Wei Ting Ho, Mohana Ray, Lijia Ma, Gregorio Fazzi, Kevin Junliang Lim, Giovani Claresta Wijaya, Shenli Zhang, Tannistha Nandi, Tingdong Yan, Mei Mei Chang, Kakoli Das, Zul Fazreen Adam Isa, Jeanie Wu, Polly Suk Yean Poon, Yue Ning Lam, Joyce Suling Lin, Su Ting Tay, Ming Hui Lee, Angie Lay Keng Tan, Xuewen Ong, Kevin White, Steven George Rozen, Michael Beer, Roger Sik Yin Foo, Heike Irmgard Grabsch, Anders Jacobsen Skanderup, Shang Li, Bin Tean Teh, and Patrick Tan
Inherited human IFN-γ deficiency underlies mycobacterial disease
Research
Gaspard Kerner, Jérémie Rosain, Antoine Guérin, Ahmad Al-Khabaz, Carmen Oleaga-Quintas, Franck Rapaport, Michel J. Massaad, Jing-Ya Ding, Taushif Khan, Fatima Al Ali, Mahbuba Rahman, Caroline Deswarte, Rubén Martinez-Barricarte, Raif S. Geha, Valentine Jeanne-Julien, Diane Garcia, Chih-Yu Chi, Rui Yang, Manon Roynard, Bernhard Fleckenstein, Flore Rozenberg, Stéphanie Boisson-Dupuis, Cheng-Lung Ku, Yoann Seeleuthner, Vivien Béziat, Nico Marr, Laurent Abel, Waleed Al-Herz, Jean-Laurent Casanova, and Jacinta Bustamante
B cell–intrinsic TLR9 expression is protective in murine lupus
Research
Jeremy S. Tilstra, Shinu John, Rachael A. Gordon, Claire Leibler, Michael Kashgarian, Sheldon Bastacky, Kevin M. Nickerson, and Mark J. Shlomchik
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration
Research
Abhishek Jauhari, Sergei V. Baranov, Yalikun Suofu, Jinho Kim, Tanisha Singh, Svitlana Yablonska, Fang Li, Xiaomin Wang, Patrick Oberly, M. Beth Minnigh, Samuel M. Poloyac, Diane L. Carlisle, and Robert M. Friedlander
Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection
Research
Xiaoming Cheng, Takuro Uchida, Yuchen Xia, Regina Umarova, Chun-Jen Liu, Pei-Jer Chen, Anuj Gaggar, Vithika Suri, Marcus M. Mücke, Johannes Vermehren, Stefan Zeuzem, Yuji Teraoka, Mitsutaka Osawa, Hiroshi Aikata, Keiji Tsuji, Nami Mori, Shuhei Hige, Yoshiyasu Karino, Michio Imamura, Kazuaki Chayama, and T. Jake Liang
Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics
Clinical Medicine
Gordon I. Smith, David C. Polidori, Mihoko Yoshino, Monica L. Kearney, Bruce W. Patterson, Bettina Mittendorfer, and Samuel Klein
Taxane resistance in prostate cancer is mediated by decreased drug-target engagement
Research
Ada Gjyrezi, Fang Xie, Olga Voznesensky, Prateek Khanna, Carla Calagua, Yang Bai, Justin Kung, Jim Wu, Eva Corey, Bruce Montgomery, Sandrine Mace, Diego A. Gianolio, Glenn J. Bubley, Steven P. Balk, Paraskevi Giannakakou, and Rupal S. Bhatt
Longitudinal study reveals HIV-1–infected CD4+ T cell dynamics during long-term antiretroviral therapy
Research
Annukka A.R. Antar, Katharine M. Jenike, Sunyoung Jang, Danielle N. Rigau, Daniel B. Reeves, Rebecca Hoh, Melissa R. Krone, Jeanne C. Keruly, Richard D. Moore, Joshua T. Schiffer, Bareng A.S. Nonyane, Frederick M. Hecht, Steven G. Deeks, Janet D. Siliciano, Ya-Chi Ho, and Robert F. Siliciano
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation
Research
Wenqiang Cao, Fengqin Fang, Timothy Gould, Xuanying Li, Chulwoo Kim, Claire Gustafson, Simon Lambert, Cornelia M. Weyand, and Jörg J. Goronzy
Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility
Research
Lan Ye, Ge Li, Anna Goebel, Abhinav V. Raju, Feng Kong, Yanfei Lv, Kailin Li, Yuanjun Zhu, Shreya Raja, Peijian He, Fang Li, Simon Musyoka Mwangi, Wenhui Hu, and Shanthi Srinivasan
Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis
Clinical Medicine
Vance G. Fowler Jr., Anita F. Das, Joy Lipka-Diamond, Raymond Schuch, Roger Pomerantz, Luis Jáuregui-Peredo, Adam Bressler, David Evans, Gregory J. Moran, Mark E. Rupp, Robert Wise, G. Ralph Corey, Marcus Zervos, Pamela S. Douglas, and Cara Cassino
Macrophages use a bet-hedging strategy for antimicrobial activity in phagolysosomal acidification
Research
Quigly Dragotakes, Kaitlin M. Stouffer, Man Shun Fu, Yehonatan Sella, Christine Youn, Olivia Insun Yoon, Carlos M. De Leon-Rodriguez, Joudeh B. Freij, Aviv Bergman, and Arturo Casadevall
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
Research
Min-Hee Oh, Im-Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson M. Englert, Matthew L. Arwood, Jiayu Wen, Yee Chan-Li, Lukáš Tenora, Pavel Majer, Rana Rais, Barbara S. Slusher, Maureen R. Horton, and Jonathan D. Powell
Complement factor H–deficient mice develop spontaneous hepatic tumors
Research
Jennifer Laskowski, Brandon Renner, Matthew C. Pickering, Natalie J. Serkova, Peter M. Smith-Jones, Eric T. Clambey, Raphael A. Nemenoff, and Joshua M. Thurman
Gut microbiome communication with bone marrow regulates susceptibility to amebiasis
Concise Communication
Stacey L. Burgess, Jhansi L. Leslie, Jashim Uddin, David N. Oakland, Carol Gilchrist, G. Brett Moreau, Koji Watanabe, Mahmoud Saleh, Morgan Simpson, Brandon A. Thompson, David T. Auble, Stephen D. Turner, Natasa Giallourou, Jonathan Swann, Zhen Pu, Jennie Z. Ma, Rashidul Haque, and William A. Petri Jr.
Long-range cis-regulatory elements controlling GDF6 expression are essential for ear development
Concise Communication
Guney Bademci, Clemer Abad, Filiz B. Cengiz, Serhat Seyhan, Armagan Incesulu, Shengru Guo, Suat Fitoz, Emine Ikbal Atli, Nicholas C. Gosstola, Selma Demir, Brett M. Colbert, Gozde Cosar Seyhan, Claire J. Sineni, Duygu Duman, Hakan Gurkan, Cynthia C. Morton, Derek M. Dykxhoorn, Katherina Walz, and Mustafa Tekin
Genomic landscape of metastatic breast cancer identifies preferentially dysregulated pathways and targets
Research
Matt R. Paul, Tien-chi Pan, Dhruv K. Pant, Natalie N.C. Shih, Yan Chen, Kyra L. Harvey, Aaron Solomon, David Lieberman, Jennifer J.D. Morrissette, Danielle Soucier-Ernst, Noah G. Goodman, S. William Stavropoulos, Kara N. Maxwell, Candace Clark, George K. Belka, Michael Feldman, Angela DeMichele, and Lewis A. Chodosh
AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes
Research
Ali Dehnad, Weiguo Fan, Joy X. Jiang, Sarah R. Fish, Yuan Li, Suvarthi Das, Gergely Mozes, Kimberly A. Wong, Kristin A. Olson, Gregory W. Charville, Mohammed Ali, and Natalie J. Török
Residual endotoxin induces primary graft dysfunction through ischemia/reperfusion-primed alveolar macrophages
Research
Mahzad Akbarpour, Emilia Lecuona, Stephen F. Chiu, Qiang Wu, Melissa Querrey, Ramiro Fernandez, Félix L. Núñez-Santana, Haiying Sun, Sowmya Ravi, Chitaru Kurihara, James M. Walter, Nikita Joshi, Ziyou Ren, Scott C. Roberts, Alan Hauser, Daniel Kreisel, Wenjun Li, Navdeep S. Chandel, Alexander V. Misharin, Thalachallour Mohanakumar, G.R. Scott Budinger, and Ankit Bharat
Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity
Research
Ze Zheng, Keiko Nakamura, Shana Gershbaum, Xiaobo Wang, Sherry Thomas, Marc Bessler, Beth Schrope, Abraham Krikhely, Rui-Ming Liu, Lale Ozcan, José A. López, and Ira Tabas
Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy
Research
Rocio Bengoechea, Andrew R. Findlay, Ankan K. Bhadra, Hao Shao, Kevin C. Stein, Sara K. Pittman, Jil A.W. Daw, Jason E. Gestwicki, Heather L. True, and Conrad C. Weihl
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness
Research
Haiquan Lu, Yangyiran Xie, Linh Tran, Jie Lan, Yongkang Yang, Naveena L. Murugan, Ru Wang, Yueyang J. Wang, and Gregg L. Semenza
FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages
Research
Arielle M. Bryan, Jeehyun Karen You, Travis McQuiston, Cristina Lazzarini, Zhijuan Qiu, Brian Sheridan, Barbara Nuesslein-Hildesheim, and Maurizio Del Poeta
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease
Research
Sherrie J. Divito, Anders T. Aasebø, Tiago R. Matos, Pei-Chen Hsieh, Matthew Collin, Christopher P. Elco, John T. O’Malley, Espen S. Bækkevold, Henrik Reims, Tobias Gedde-Dahl, Michael Hagerstrom, Jude Hilaire, John W. Lian, Edgar L. Milford, Geraldine S. Pinkus, Vincent T. Ho, Robert J. Soiffer, Haesook T. Kim, Martin C. Mihm, Jerome Ritz, Indira Guleria, Corey S. Cutler, Rachael A. Clark, Frode L. Jahnsen, and Thomas S. Kupper
Anti–influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface
Concise Communication
Jinhui Dong, Iuliia Gilchuk, Sheng Li, Ryan Irving, Matthew T. Goff, Hannah L. Turner, Andrew B. Ward, Robert H. Carnahan, and James E. Crowe Jr.
Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis
Research
Melanie C. Dispenza, Rebecca A. Krier-Burris, Krishan D. Chhiba, Bradley J. Undem, Piper A. Robida, and Bruce S. Bochner
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII
Research
Klitos Konstantinidis, Vassilios J. Bezzerides, Lo Lai, Holly M. Isbell, An-Chi Wei, Yuejin Wu, Meera C. Viswanathan, Ian D. Blum, Jonathan M. Granger, Danielle Heims-Waldron, Donghui Zhang, Elizabeth D. Luczak, Kevin R. Murphy, Fujian Lu, Daniel H. Gratz, Bruno Manta, Qiang Wang, Qinchuan Wang, Alex L. Kolodkin, Vadim N. Gladyshev, Thomas J. Hund, William T. Pu, Mark N. Wu, Anthony Cammarato, Mario A. Bianchet, Madeline A. Shea, Rodney L. Levine, and Mark E. Anderson
Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias
Research
Shaohua Xiao, Daisuke Shimura, Rachel Baum, Diana M. Hernandez, Sosse Agvanian, Yoshiko Nagaoka, Makoto Katsumata, Paul D. Lampe, Andre G. Kleber, TingTing Hong, and Robin M. Shaw
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration
Research
Maud Gratuze, Cheryl E.G. Leyns, Andrew D. Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T. Kummer, Marco Colonna, Jason D. Ulrich, and David M. Holtzman
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice
Research
Preeti Raju, Nitesh Shashikanth, Pei-Yun Tsai, Pawin Pongkorpsakol, Sandra Chanez-Paredes, Peter R. Steinhagen, Wei-Ting Kuo, Gurminder Singh, Sachiko Tsukita, and Jerrold R. Turner
Mapping mania symptoms based on focal brain damage
Clinical Medicine
Gonçalo Cotovio, Daniel Talmasov, J. Bernardo Barahona-Corrêa, Joey Hsu, Suhan Senova, Ricardo Ribeiro, Louis Soussand, Ana Velosa, Vera Cruz e Silva, Natalia Rost, Ona Wu, Alexander L. Cohen, Albino J. Oliveira-Maia, and Michael D. Fox
Human NK cell deficiency as a result of biallelic mutations in MCM10
Research
Emily M. Mace, Silke Paust, Matilde I. Conte, Ryan M. Baxley, Megan M. Schmit, Sagar L. Patil, Nicole C. Guilz, Malini Mukherjee, Ashley E. Pezzi, Jolanta Chmielowiec, Swetha Tatineni, Ivan K. Chinn, Zeynep Coban Akdemir, Shalini N. Jhangiani, Donna M. Muzny, Asbjørg Stray-Pedersen, Rachel E. Bradley, Mo Moody, Philip P. Connor, Adrian G. Heaps, Colin Steward, Pinaki P. Banerjee, Richard A. Gibbs, Malgorzata Borowiak, James R. Lupski, Stephen Jolles, Anja K. Bielinsky, and Jordan S. Orange
Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia
Research
Andrew Crispin, Chaoshe Guo, Caiyong Chen, Dean R. Campagna, Paul J. Schmidt, Daniel Lichtenstein, Chang Cao, Anoop K. Sendamarai, Gordon J. Hildick-Smith, Nicholas C. Huston, Jeanne Boudreaux, Sylvia S. Bottomley, Matthew M. Heeney, Barry H. Paw, Mark D. Fleming, and Sarah Ducamp
Improved killing of HIV-infected cells using three neutralizing and non-neutralizing antibodies
Research
Marina Tuyishime, Carolina Garrido, Shalini Jha, Matt Moeser, Dieter Mielke, Celia LaBranche, David Montefiori, Barton F. Haynes, Sarah Joseph, David M. Margolis, and Guido Ferrari
A coagulation defect arising from heterozygous premature termination of tissue factor
Research
Sol Schulman, Emale El-Darzi, Mary H.C. Florido, Max Friesen, Glenn Merrill-Skoloff, Marisa A. Brake, Calvin R. Schuster, Lin Lin, Randal J. Westrick, Chad A. Cowan, Robert Flaumenhaft, NIHR BioResource, Willem H. Ouwehand, Kathelijne Peerlinck, Kathleen Freson, Ernest Turro, and Bruce Furie
Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression
Research
Anqun Chen, Ye Feng, Han Lai, Wenjun Ju, Zhengzhe Li, Yu Li, Andrew Wang, Quan Hong, Fang Zhong, Chengguo Wei, Jia Fu, Tianjun Guan, Bichen Liu, Matthias Kretzler, Kyung Lee, and John Cijiang He
Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema
Research
Xinguo Jiang, Wen Tian, Eric J. Granucci, Allen B. Tu, Dongeon Kim, Petra Dahms, Shravani Pasupneti, Gongyong Peng, Yesl Kim, Amber H. Lim, F. Hernan Espinoza, Matthew Cribb, J. Brandon Dixon, Stanley G. Rockson, Gregg L. Semenza, and Mark R. Nicolls
Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients
Research
Kazusa Ishii, Marie Pouzolles, Christopher D. Chien, Rebecca A. Erwin-Cohen, M. Eric Kohler, Haiying Qin, Haiyan Lei, Skyler Kuhn, Amanda K. Ombrello, Alina Dulau-Florea, Michael A. Eckhaus, Haneen Shalabi, Bonnie Yates, Daniel A. Lichtenstein, Valérie S. Zimmermann, Taisuke Kondo, Jack F. Shern, Howard A. Young, Naomi Taylor, Nirali N. Shah, and Terry J. Fry
Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder
Clinical Medicine
Matthew K. Schindler, Stefania Pittaluga, Yoshimi Enose-Akahata, Helen C. Su, V. Koneti Rao, Amy Rump, Steven Jacobson, Irene Cortese, Daniel S. Reich, and Gulbu Uzel
DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas
Research
Anat Ben-Shlomo, Nan Deng, Evelyn Ding, Masaaki Yamamoto, Adam Mamelak, Vera Chesnokova, Artak Labadzhyan, and Shlomo Melmed
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming
Research
Fei Li, Qiuyue Yuan, Wei Di, Xinyi Xia, Zhuang Liu, Ninghui Mao, Lin Li, Chunfeng Li, Juan He, Yunguang Li, Wangxin Guo, Xiaoyu Zhang, Yiqin Zhu, Rebiguli Aji, Shangqian Wang, Xinyuan Tong, Hongbin Ji, Ping Chi, Brett Carver, Yong Wang, Yu Chen, and Dong Gao
Complement activation on endothelium initiates antibody-mediated acute lung injury
Research
Simon J. Cleary, Nicholas Kwaan, Jennifer J. Tian, Daniel R. Calabrese, Beñat Mallavia, Mélia Magnen, John R. Greenland, Anatoly Urisman, Jonathan P. Singer, Steven R. Hays, Jasleen Kukreja, Ariel M. Hay, Heather L. Howie, Pearl Toy, Clifford A. Lowell, Craig N. Morrell, James C. Zimring, and Mark R. Looney
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2
Clinical Medicine
Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, and Hamid Bassiri
Metabolic effects of air pollution exposure and reversibility
Concise Communication
Sanjay Rajagopalan, Bongsoo Park, Rengasamy Palanivel, Vinesh Vinayachandran, Jeffrey A. Deiuliis, Roopesh Singh Gangwar, Lopa Das, Jinhu Yin, Youngshim Choi, Sadeer Al-Kindi, Mukesh K. Jain, Kasper D. Hansen, and Shyam Biswal
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure
Clinical Medicine
Bo Zhou, Dennis Ding-Hwa Wang, Yanhua Qiu, Sophia Airhart, Yaxin Liu, April Stempien-Otero, Kevin D. O’Brien, and Rong Tian
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma
Research
Jason Yongsheng Chan, Jing Quan Lim, Joe Yeong, Vinod Ravi, Peiyong Guan, Arnoud Boot, Timothy Kwang Yong Tay, Sathiyamoorthy Selvarajan, Nur Diyana Md Nasir, Jie Hua Loh, Choon Kiat Ong, Dachuan Huang, Jing Tan, Zhimei Li, Cedric Chuan-Young Ng, Thuan Tong Tan, Mikio Masuzawa, Ken Wing-Kin Sung, Mohamad Farid, Richard Hong Hui Quek, Ngian Chye Tan, Melissa Ching Ching Teo, Steven George Rozen, Patrick Tan, Andrew Futreal, Bin Tean Teh, and Khee Chee Soo
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population
Research
Sabra L. Klein, Andrew Pekosz, Han-Sol Park, Rebecca L. Ursin, Janna R. Shapiro, Sarah E. Benner, Kirsten Littlefield, Swetha Kumar, Harnish Mukesh Naik, Michael J. Betenbaugh, Ruchee Shrestha, Annie A. Wu, Robert M. Hughes, Imani Burgess, Patricio Caturegli, Oliver Laeyendecker, Thomas C. Quinn, David Sullivan, Shmuel Shoham, Andrew D. Redd, Evan M. Bloch, Arturo Casadevall, and Aaron A.R. Tobian
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma
Clinical Medicine
Sabine Mueller, Jared M. Taitt, Javier E. Villanueva-Meyer, Erin R. Bonner, Takahide Nejo, Rishi R. Lulla, Stewart Goldman, Anu Banerjee, Susan N. Chi, Nicholas S. Whipple, John R. Crawford, Karen Gauvain, Kellie J. Nazemi, Payal B. Watchmaker, Neil D. Almeida, Kaori Okada, Andres M. Salazar, Ryan D. Gilbert, Javad Nazarian, Annette M. Molinaro, Lisa H. Butterfield, Michael D. Prados, and Hideho Okada
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris
Concise Communication
Jinmin Lee, Daniel K. Lundgren, Xuming Mao, Silvio Manfredo-Vieira, Selene Nunez-Cruz, Erik F. Williams, Charles-Antoine Assenmacher, Enrico Radaelli, Sangwook Oh, Baomei Wang, Christoph T. Ellebrecht, Joseph A. Fraietta, Michael C. Milone, and Aimee S. Payne
Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion
Research
Valerie Clerin, Hiroshi Saito, Kevin J. Filipski, An Hai Nguyen, Jeonifer Garren, Janka Kisucka, Monica Reyes, and Harald Jüppner
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity
Clinical Medicine
Vincenza Cifarelli, Scott C. Beeman, Gordon I. Smith, Jun Yoshino, Darya Morozov, Joseph W. Beals, Brandon D. Kayser, Jeramie D. Watrous, Mohit Jain, Bruce W. Patterson, and Samuel Klein
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity
Research
Selami Demirci, Jing Zeng, Yuxuan Wu, Naoya Uchida, Anne H. Shen, Danilo Pellin, Jackson Gamer, Morgan Yapundich, Claire Drysdale, Jasmine Bonanno, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Theresa Engels, Robert E. Donahue, Juan J. Haro-Mora, Alexis Leonard, Tina Nassehi, Kevin Luk, Shaina N. Porter, Cicera R. Lazzarotto, Shengdar Q. Tsai, Mitchell J. Weiss, Shondra M. Pruett-Miller, Scot A. Wolfe, Daniel E. Bauer, and John F. Tisdale
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Research
Eric Salazar, Suresh V. Kuchipudi, Paul A. Christensen, Todd Eagar, Xin Yi, Picheng Zhao, Zhicheng Jin, S. Wesley Long, Randall J. Olsen, Jian Chen, Brian Castillo, Christopher Leveque, Dalton Towers, Jason Lavinder, Jimmy Gollihar, Jose Cardona, Gregory Ippolito, Ruth Nissly, Ian Bird, Denver Greenawalt, Randall M. Rossi, Abhinay Gontu, Sreenidhi Srinivasan, Indira Poojary, Isabella M. Cattadori, Peter J. Hudson, Nicole M. Josleyn, Laura Prugar, Kathleen Huie, Andrew Herbert, David W. Bernard, John M. Dye, Vivek Kapur, and James M. Musser
Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance
Research
Wenjun Li, Jason M. Gauthier, Alice Y. Tong, Yuriko Terada, Ryuji Higashikubo, Christian C. Frye, Margaret S. Harrison, Kohei Hashimoto, Amit I. Bery, Jon H. Ritter, Ruben G. Nava, Varun Puri, Brian W. Wong, Kory J. Lavine, Ankit Bharat, Alexander S. Krupnick, Andrew E. Gelman, and Daniel Kreisel
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor
Research
Justin Taylor, Mark T.A. Donoghue, Caleb Ho, Kseniya Petrova-Drus, Hikmat A. Al-Ahmadie, Samuel A. Funt, Yanming Zhang, Umut Aypar, Pavitra Rao, Shweta S. Chavan, Michael Haddadin, Roni Tamari, Sergio Giralt, Martin S. Tallman, Raajit K. Rampal, Priscilla Baez, Rajya Kappagantula, Satyajit Kosuri, Ahmet Dogan, Satish K. Tickoo, Victor E. Reuter, George J. Bosl, Christine A. Iacobuzio-Donahue, David B. Solit, Barry S. Taylor, Darren R. Feldman, and Omar Abdel-Wahab
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2
Clinical Medicine
Bezawit A. Woldemeskel, Abena K. Kwaa, Caroline C. Garliss, Oliver Laeyendecker, Stuart C. Ray, and Joel N. Blankson

Posted in JCI

JCI Editor’s update, December 2019

Posted on by Maya Hoptman

Dear Colleague,

As the year draws to a close, I wanted to take the opportunity to update you on recent JCI activity. The Journal continues to build on its history of publishing outstanding biomedical research, garnering wide attention in the scientific literature, the press, and social media (highlighted below). In particular, the Clinical Medicine category, now in its seventh year, continues to flourish, with 25 articles published in 2019. Among these were two of the highest-cited JCI papers of the year, on the role of androgen receptor splice variant-7 in castration-resistant prostate cancer; and the use of B cell maturation antigen–targeted CAR T cells in multiple myeloma. We welcome submissions from ASCI members reporting new medical therapies, interventions, diagnostic advances, or observational studies in humans that have the potential to change medical practice.

Viewpoint articles have given voice to experts and thought leaders in medicine, academia, nonprofit organizations, industry, and representatives of the JCI and ASCI on subjects of topical and long-term interest. In one recent Viewpoint (available here), the women on the JCI Editorial Board share their perspective on achieving equity for women and underrepresented minorities in academic medicine leadership, including in societies and journals. In another, Kieren Marr (2018-19 ASCI President) et al. discuss the Society’s strategic support of physician-scientists. In early January, look for a series of Viewpoints on the effects of climate change on human health.

The Journal published four Review Series this year, on mechanisms underlying the metabolic syndrome, reparative immunology, allergy, and familial cancer predisposition syndromes, the latter three with series editors who are ASCI members. Individual Reviews covered a range of subjects, from vaccines to endocrinology to neurology, including a highly cited article on the functional significance of platelet immune receptors.

Reminders:

  • ASCI members who are the corresponding author of a first-round submission to the JCI, and whose dues are current, may designate one submission per calendar year to be guaranteed for external peer review. For details, visit the For Authors page.
  • Authors may transfer manuscripts from the preprint server bioRxiv for submission to the JCI.

I wish you all the best for the New Year, and look forward to reading your best work.

Sincerely,

Rexford S. Ahima, MD, PhD
Editor, The Journal of Clinical Investigation

The JCI in selected news outlets, 2019

Source: Altmetric. Corresponding authors who are ASCI members are indicated in bold.

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases
Research
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, and Lei Liu

Mentioned in BBC News

Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Research
Matthew C. Madison, Cameron T. Landers, Bon-Hee Gu, Cheng-Yen Chang, Hui-Ying Tung, Ran You, Monica J. Hong, Nima Baghaei, Li-Zhen Song, Paul Porter, Nagireddy Putluri, Ramiro Salas, Brian E. Gilbert, Ilya Levental, Matthew J. Campen, David B. Corry, and Farrah Kheradmand

Mentioned in Japan Times; Haaretz (Israel); US News and World Report; WIRED

The physician-scientist: defending vaccines and combating antiscience
Viewpoint
Peter Hotez

Mentioned in Newsweek

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease
Clinical Medicine
David C. Fajgenbaum, Ruth-Anne Langan, Alberto Sada Japp, Helen L. Partridge, Sheila K. Pierson, Amrit Singh, Daniel J. Arenas, Jason R. Ruth, Christopher S. Nabel, Katie Stone, Mariko Okumura, Anthony Schwarer, Fábio Freire Jose, Nelson Hamerschlak, Gerald B. Wertheim, Michael B. Jordan, Adam D. Cohen, Vera Krymskaya, Arthur Rubenstein, Michael R. Betts, Taku Kambayashi, Frits van Rhee, and Thomas S. Uldrick

Mentioned in Newsweek

Cingulum stimulation enhances positive affect and anxiolysis to facilitate awake craniotomy
Clinical Medicine
Kelly R. Bijanki, Joseph R. Manns, Cory S. Inman, Ki Sueng Choi, Sahar Harati, Nigel P. Pedersen, Daniel L. Drane, Allison C. Waters, Rebecca E. Fasano, Helen S. Mayberg, and Jon T. Willie

Mentioned in Discover Magazine and Der Spiegel

Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition
Concise Communication
Kentaro Kaneko, Yukiko Fu, Hsiao-Yun Lin, Elizabeth L. Cordonier, Qianxing Mo, Yong Gao, Ting Yao, Jacqueline Naylor, Victor Howard, Kenji Saito, Pingwen Xu, Siyu S. Chen, Miao-Hsueh Chen, Yong Xu, Kevin W. Williams, Peter Ravn, and Makoto Fukuda

Mentioned in Wiener-Zeitung (Austria); Daily Mail (United Kingdom)

Social media activity: Twitter

Source: Altmetric, November 2019. Corresponding authors who are ASCI members are indicated in bold.

Promises, promises, and precision medicine
Viewpoint
Michael J. Joyner and Nigel Paneth

Twitter mentions: 395

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases
Research
Dipak Panigrahy, Allison Gartung, Jun Yang, Haixia Yang, Molly M. Gilligan, Megan L. Sulciner, Swati S. Bhasin, Diane R. Bielenberg, Jaimie Chang, Birgitta A. Schmidt, Julia Piwowarski, Anna Fishbein, Dulce Soler-Ferran, Matthew A. Sparks, Steven J. Staffa, Vidula Sukhatme, Bruce D. Hammock, Mark W. Kieran, Sui Huang, Manoj Bhasin, Charles N. Serhan, and Vikas P. Sukhatme

Twitter mentions: 322

Elevation of plasma tRNA fragments precedes seizures in human epilepsy
Concise Communication
Marion C. Hogg, Rana Raoof, Hany El Naggar, Naser Monsefi, Norman Delanty, Donncha F. O’Brien, Sebastian Bauer, Felix Rosenow, David C. Henshall, and Jochen H.M. Prehn

Twitter mentions: 218

Highest-cited research published in 2019

Source: Web of Science as of November 25, 2019. Corresponding authors who are ASCI members are indicated in bold.

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer
Clinical Medicine
Adam Sharp, Ilsa Coleman, Wei Yuan, Cynthia Sprenger, David Dolling, Daniel Nava Rodrigues, Joshua W. Russo, Ines Figueiredo, Claudia Bertan, George Seed, Ruth Riisnaes, Takuma Uo, Antje Neeb, Jonathan Welti, Colm Morrissey, Suzanne Carreira, Jun Luo, Peter S. Nelson, Steven P. Balk, Lawrence D. True, Johann S. de Bono, and Stephen R. Plymate

Times cited: 23

APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production
Research
Feng-Wei Wang, Chen-Hui Cao, Kai Han, Yong-Xiang Zhao, Mu-Yan Cai, Zhi-Cheng Xiang, Jia-Xing Zhang, Jie-Wei Chen, Li-Ping Zhong, Yong Huang, Su-Fang Zhou, Xiao-Han Jin, Xin-Yuan Guan, Rui-Hua Xu, and Dan Xie

Times cited: 22

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer
Research
Roman M. Chabanon, Gareth Muirhead, Dragomir B. Krastev, Julien Adam, Daphné Morel, Marlène Garrido, Andrew Lamb, Clémence Hénon, Nicolas Dorvault, Mathieu Rouanne, Rebecca Marlow, Ilirjana Bajrami, Marta Llorca Cardeñosa, Asha Konde, Benjamin Besse, Alan Ashworth, Stephen J. Pettitt, Syed Haider, Aurélien Marabelle, Andrew N.J. Tutt, Jean-Charles Soria, Christopher J. Lord, and Sophie Postel-Vinay

Times cited: 14

B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma
Clinical Medicine
Adam D. Cohen, Alfred L. Garfall, Edward A. Stadtmauer, J. Joseph Melenhorst, Simon F. Lacey, Eric Lancaster, Dan T. Vogl, Brendan M. Weiss, Karen Dengel, Annemarie Nelson, Gabriela Plesa, Fang Chen, Megan M. Davis, Wei-Ting Hwang, Regina M. Young, Jennifer L. Brogdon, Randi Isaacs, Iulian Pruteanu-Malinici, Don L. Siegel, Bruce L. Levine, Carl H. June, and Michael C. Milone

Times cited: 13

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis
Research
Yongsheng Yu, Yu Liu, Weishuai An, Jingwen Song, Yuefan Zhang, and Xianxian Zhao

Times cited: 12

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia
Research
Toshiro Saito, Jihoon Nah, Shin-ichi Oka, Risa Mukai, Yoshiya Monden, Yasuhiro Maejima, Yoshiyuki Ikeda, Sebastiano Sciarretta, Tong Liu, Hong Li, Erdene Baljinnyam, Diego Fraidenraich, Luke Fritzky, Peiyong Zhai, Shizuko Ichinose, Mitsuaki Isobe, Chiao-Po Hsu, Mondira Kundu, and Junichi Sadoshima

Times cited: 12

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Research
Yong Pan, Xiaoyan Hui, Ruby Lai Chong Hoo, Dewei Ye, Cyrus Yuk Cheung Chan, Tianshi Feng, Yu Wang, Karen Siu Ling Lam, and Aimin Xu

Times cited: 12

Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression
Research
Bing Song, Su-Hong Park, Jonathan C. Zhao, Ka-wing Fong, Shangze Li, Yongik Lee, Yeqing A. Yang, Subhasree Sridhar, Xiaodong Lu, Sarki A. Abdulkadir, Robert L. Vessella, Colm Morrissey, Timothy M. Kuzel, William Catalona, Ximing Yang, and Jindan Yu

Times cited: 10

JCI research with ASCI members as corresponding authors, 2019

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup
Stephanie A. Christenson, Maarten van den Berge, Alen Faiz, Kai Inkamp, Nirav Bhakta, Luke R. Bonser, Lorna T. Zlock, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Richard C. Boucher, Russell P. Bowler, Alejandro P. Comellas, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Pieter S. Hiemstra, Robert J. Kaner, Jerry A. Krishnanm, Fernando J. Martinez, Wanda K. O’Neal, Robert Paine III, Wim Timens, J. Michael Wells, Avrum Spira, David J. Erle, and Prescott G. Woodruff
P13K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression
Shuai Dong, Bonnie K. Harrington, Eileen Y. Hu, Joseph T. Greene, Amy M. Lehman, Minh Tran, Ronni L. Wasmuth, Meixiao Long, Natarajan Muthusamy, Jennifer R. Brown, Amy J. Johnson, and John C. Byrd
Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
Sungro Jo, Tatiana L. Fonseca, Barbara M. L. C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Anaysa P. Bolin, Rodrigo R. Da Conceição, Joao Pedro Werneck-de-Castro, Daniele L. Ignacio, Péter Egri, Dorottya Németh, Csaba Fekete, Maria Martha Bernardi, Victoria D. Leitch, Naila S. Mannan, Katharine F. Curry, Natalie C. Butterfield, J.H. Duncan Bassett, Graham R. Williams, Balázs Gereben, Miriam O. Ribeiro, and Antonio C. Bianco
Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
Jun Wei, Anantha Marisetty, Brett Schrand, Konrad Gabrusiewicz, Yuuri Hashimoto, Martina Ott, Zacharia Grami, Ling-Yuan Kong, Xiaoyang Ling, Hillary Caruso, Shouhao Zhou, Y. Alan Wang, Gregory N. Fuller, Jason Huse, Eli Gilboa, Nannan Kang, Xingxu Huang, Roel Verhaak, Shulin Li, and Amy B. Heimberger
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity
Chien-Chun Steven Pai, Donald M. Simons, Xiaoqing Lu, Michael Evans, Junnian Wei, Yung-hua Wang, Mingyi Chen, John Huang, Chanhyuk Park, Anthony Chang, Jiaxi Wang, Susan Westmoreland, Christine Beam, Dave Banach, Diana Bowley, Feng Dong, Jane Seagal, Wendy Ritacco, Paul L. Richardson, Soumya Mitra, Grace Lynch, Pete Bousquet, John Mankovich, Gillian Kingsbury, and Lawrence Fong
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
Ming Chen, Jiangwen Zhang, Alice H. Berger, Moussa S. Diolombi, Christopher Ng, Jacqueline Fung, Roderick T. Bronson, Mireia Castillo-Martin, Tin Htwe Thin, Carlos Cordon-Cardo, Robin Plevin, and Pier Paolo Pandolfi
L-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
Robert A. Koeth, Betzabe Rachel Lam-Galvez, Jennifer Kirsop, Zeneng Wang, Bruce S. Levison, Xiaodong Gu, Matthew F. Copeland, David Bartlett, David B. Cody, Hong J. Dai, Miranda K. Culley, Xinmin S. Li, Xiaoming Fu, Yuping Wu, Lin Li, Joseph A. DiDonato, W.H. Wilson Tang, Jose Carlos Garcia-Garcia, and Stanley L. Hazen
An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia
Toshiro Saito, Jihoon Nah, Shin-ichi Oka, Risa Mukai, Yoshiya Monden, Yasuhiro Maejima, Yoshiyuki Ikeda, Sebastiano Sciarretta, Tong Liu, Hong Li, Erdene Baljinnyam, Diego Fraidenraich, Luke Fritzky, Peiyong Zhai, Shizuko Ichinose, Mitsuaki Isobe, Chiao-Po Hsu, Mondira Kundu, and Junichi Sadoshima
Cardiac CaV1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking
Lin Yang, Alexander Katchman, Jared Kushner, Alexander Kushnir, Sergey I. Zakharov, Bi-xing Chen, Zunaira Shuja, Prakash Subramanyam, Guoxia Liu, Arianne Papa, Daniel Roybal, Geoffrey S. Pitt, Henry M. Colecraft, and Steven O. Marx
Rescue of recurrent deep intronic mutation underlying cell type–dependent quantitative NEMO deficiency
Bertrand Boisson, Yoshitaka Honda, Masahiko Ajiro, Jacinta Bustamante, Matthieu Bendavid, Andrew R. Gennery, Yuri Kawasaki, Jose Ichishima, Mitsujiro Osawa, Hiroshi Nihira, Takeshi Shiba, Takayuki Tanaka, Maya Chrabieh, Benedetta Bigio, Hong Hur, Yuval Itan, Yupu Liang, Satoshi Okada, Kazushi Izawa, Ryuta Nishikomori, Osamu Ohara, Toshio Heike, Laurent Abel, Anne Puel, Megumu K. Saito, Jean-Laurent Casanova, Masatoshi Hagiwara, and Takahiro Yasumi
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia
Hongjie Wang, Aphrodite Georgakopoulou, Nikoletta Psatha, Chang Li, Chrysi Capsali, Himanshu Bhusan Samal, Achilles Anagnostopoulos, Anja Ehrhardt, Zsuzsanna Izsvák, Thalia Papayannopoulou, Evangelia Yannaki, and André Lieber
Gene fitness landscape of group A streptococcus during necrotizing myositis
Luchang Zhu, Randall J. Olsen, Stephen B. Beres, Jesus M. Eraso, Matthew Ojeda Saavedra, Samantha L. Kubiak, Concepcion C. Cantu, Leslie Jenkins, Amelia R. L. Charbonneau, Andrew S. Waller, and James M. Musser
HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia
Alejandro A. Pezzulo, Rosarie A. Tudas, Carley G. Stewart, Luis G. Vargas Buonfiglio, Brian D. Lindsay, Peter J. Taft, Nicholas D. Gansemer, and Joseph Zabner
Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
Sahra Bodo, Cécile Campagne, Tin Htwe Thin, Daniel S. Higginson, H. Alberto Vargas, Guoqiang Hua, John D. Fuller, Ellen Ackerstaff, James Russell, Zhigang Zhang, Stefan Klingler, HyungJoon Cho, Matthew G. Kaag, Yousef Mazaheri, Andreas Rimner, Katia Manova-Todorova, Boris Epel, Joan Zatcky, Cristian R. Cleary, Shyam S. Rao, Yoshiya Yamada, Michael J. Zelefsky, Howard J. Halpern, Jason A. Koutcher, Carlos Cordon-Cardo, Carlo Greco, Adriana Haimovitz-Friedman, Evis Sala, Simon N. Powell, Richard Kolesnick, and Zvi Fuks
Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection
Wenjun Li, Jason M. Gauthier, Ryuji Higashikubo, Hsi-Min Hsiao, Satona Tanaka, Linh Vuong, Jon H. Ritter, Alice Y. Tong, Brian W. Wong, Ramsey R. Hachem, Varun Puri, Ankit Bharat, Alexander S. Krupnick, Chyi S. Hsieh, William M. Baldwin III, Francine L. Kelly, Scott M. Palmer, Andrew E. Gelman, and Daniel Kreisel
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
Sam C. Nalle, Li Zuo, Ma. Lora Drizella M. Ong, Gurminder Singh, Alicia M. Worthylake, Wangsun Choi, Mario Cabrero Manresa, Anna P. Southworth, Karen L. Edelblum, Gregory J. Baker, Nora E. Joseph, Peter A. Savage, and Jerrold R. Turner
Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome
Elena Gallo MacFarlane, Sarah J. Parker, Joseph Y. Shin, Shira G. Ziegler, Tyler J. Creamer, Rustam Bagirzadeh, Djahida Bedja, Yichun Chen, Juan F. Calderon, Katherine Weissler, Pamela A. Frischmeyer-Guerrerio, Mark E. Lindsay, Jennifer P. Habashi, and Harry C. Dietz
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy
Kevin B. Einkauf, Guinevere Q. Lee, Ce Gao, Radwa Sharaf, Xiaoming Sun, Stephane Hua, Samantha M.Y. Chen, Chenyang Jiang, Xiaodong Lian, Fatema Z. Chowdhury, Eric S. Rosenberg, Tae-Wook Chun, Jonathan Z. Li, Xu G. Yu, and Mathias Lichterfeld
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
Mattias N.D. Svensson, Karen M. Doody, Benjamin J. Schmiedel, Sourya Bhattacharyya, Bharat Panwar, Florian Wiede, Shen Yang, Eugenio Santelli, Dennis J. Wu, Cristiano Sacchetti, Ravindra Gujar, Gregory Seumois, William B. Kiosses, Isabelle Aubry, Gisen Kim, Piotr Mydel, Shimon Sakaguchi, Mitchell Kronenberg, Tony Tiganis, Michel L. Tremblay, Ferhat Ay, Pandurangan Vijayanand, and Nunzio Bottini
CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen
Shiteng Duan, Cynthia J. Koziol-White, William F. Jester Jr., Corwin M. Nycholat, Matthew S. Macauley, Reynold A. Panettieri Jr., and James C. Paulson
Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
Simona Stivala, Tamara Codilupi, Sime Brkic, Anne Baerenwaldt, Nilabh Ghosh, Hui Hao-Shen, Stephan Dirnhofer, Matthias S. Dettmer, Cedric Simillion, Beat A. Kaufmann, Sophia Chiu, Matthew Keller, Maria Kleppe, Morgane Hilpert, Andreas S. Buser, Jakob R. Passweg, Thomas Radimerski, Radek C. Skoda, Ross L. Levine, and Sara C. Meyer
Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model
Yueqin Zhou, Sharon Carmona, A.K.M.G. Muhammad, Shaughn Bell, Jesse Landeros, Michael Vazquez, Ritchie Ho, Antonietta Franco, Bin Lu, Gerald W. Dorn II, Shaomei Wang, Cathleen M. Lutz, and Robert H. Baloh
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic
Sarah Tomkovich, Christine M. Dejea, Kathryn Winglee, Julia L. Drewes, Liam Chung, Franck Housseau, Jillian L. Pope, Josee Gauthier, Xiaolun Sun, Marcus Mühlbauer, Xiuli Liu, Payam Fathi, Robert A. Anders, Sepideh Besharati, Ernesto Perez-Chanona, Ye Yang, Hua Ding, Xinqun Wu, Shaoguang Wu, James R. White, Raad Z. Gharaibeh, Anthony A. Fodor, Hao Wang, Drew M. Pardoll, Christian Jobin, and Cynthia L. Sears
Follicular lymphoma–associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR
Fangyang Wang, Damián Gatica, Zhang Xiao Ying, Luke F. Peterson, Peter Kim, Denzil Bernard, Kamlai Saiya-Cork, Shaomeng Wang, Mark S. Kaminski, Alfred E. Chang, Tycel Phillips, Daniel J. Klionsky, and Sami N. Malek
Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma
Niraj Shenoy, Tushar D. Bhagat, John Cheville, Christine Lohse, Sanchari Bhattacharyya, Alexander Tischer, Venkata Machha, Shanisha Gordon-Mitchell, Gaurav Choudhary, Li-Fan Wong, LouAnn Gross, Emily Ressigue, Bradley Leibovich, Stephen A. Boorjian, Ulrich Steidl, Xiaosheng Wu, Kith Pradhan, Benjamin Gartrell, Beamon Agarwal, Lance Pagliaro, Masako Suzuki, John M. Greally, Dinesh Rakheja, R. Houston Thompson, Katalin Susztak, Thomas Witzig, Yiyu Zou, and Amit Verma
miR-142 controls metabolic reprogramming that regulates dendritic cell activation
Yaping Sun, Katherine Oravecz-Wilson, Sydney Bridges, Richard McEachin, Julia Wu, Stephanie H. Kim, Austin Taylor, Cynthia Zajac, Hideaki Fujiwara, Daniel Christopher Peltier, Thomas Saunders, and Pavan Reddy
IL-26 contributes to host defense against intracellular bacteria
Angeline Tilly Dang, Rosane M.B. Teles, David I. Weiss, Kislay Parvatiyar, Euzenir N. Sarno, Maria T. Ochoa, Genhong Cheng, Michel Gilliet, Barry R. Bloom, and Robert L. Modlin
Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis
Ting Wen, Bruce J. Aronow, Yrina Rochman, Mark Rochman, Kiran KC, Phil J. Dexheimer, Philip Putnam, Vincent Mukkada, Heather Foote, Kira Rehn, Sam Darko, Daniel Douek, and Marc E. Rothenberg
uPAR isoform 2 forms a dimer and induces severe kidney disease in mice
Changli Wei, Jing Li, Brian D. Adair, Ke Zhu, Jian Cai, Michael Merchant, Beata Samelko, Zhongji Liao, Kwi Hye Koh, Nicholas J. Tardi, Ranadheer R. Dande, Shuangxin Liu, Jianchao Ma, Salvatore Dibartolo, Stefan Hägele, Vasil Peev, Salim S. Hayek, David J. Cimbaluk, Melissa Tracy, Jon Klein, Sanja Sever, Sanford J. Shattil, M. Amin Arnaout, and Jochen Reiser
Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells
Takahiro Kamiya, See Voon Seow, Desmond Wong, Murray Robinson, and Dario Campana
Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor
Gerardo A. Vitiello, Timothy G. Bowler, Mengyuan Liu, Benjamin D. Medina, Jennifer Q. Zhang, Nesteene J. Param, Jennifer K. Loo, Rachel L. Goldfeder, Frederic Chibon, Ferdinand Rossi, Shan Zeng, and Ronald P. DeMatteo
Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival
Patrick Kellish, Daniil Shabashvili, Masmudur M. Rahman, Akbar Nawab, Maria V. Guijarro, Min Zhang, Chunxia Cao, Nissin Moussatche, Theresa Boyle, Scott Antonia, Mary Reinhard, Connor Hartzell, Michael Jantz, Hiren J. Mehta, Grant McFadden, Frederic J. Kaye, and Maria Zajac-Kaye
Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage
Hasina Outtz Reed, Liqing Wang, Jarrod Sonett, Mei Chen, Jisheng Yang, Larry Li, Petra Aradi, Zoltan Jakus, Jeanine D’Armiento, Wayne W. Hancock, and Mark L. Kahn
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
Wenjun Li, Guoshuai Feng, Jason M. Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka, Hsi-Min Hsiao, Daniel Ruiz-Perez, Andrea Bredemeyer, Richard W. Gross, Douglas L. Mann, Yulia Y. Tyurina, Andrew E. Gelman, Valerian E. Kagan, Andreas Linkermann, Kory J. Lavine, and Daniel Kreisel
Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis
Martin D. Burkhalter, Arthi Sridhar, Pedro Sampaio, Raquel Jacinto, Martina S. Burczyk, Cornelia Donow, Max Angenendt, Competence Network for Congenital Heart Defects Investigators, Maja Hempel, Paul Walther, Petra Pennekamp, Heymut Omran, Susana S. Lopes, Stephanie M. Ware, and Melanie Philipp
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking
Jingzhu Zhang, Teerawit Supakorndej, Joseph R. Krambs, Mahil Rao, Grazia Abou-Ezzi, Rachel Y. Ye, Sidan Li, Kathryn Trinkaus, and Daniel C. Link
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
Ajay Abraham, Shaowei Qiu, Balu K. Chacko, Hui Li, Andrew Paterson, Jianbo He, Puneet Agarwal, Mansi Shah, Robert Welner, Victor M. Darley-Usmar, and Ravi Bhatia
Aberrant splicing contributes to severe α-spectrin–linked congenital hemolytic anemia
Patrick G. Gallagher, Yelena Maksimova, Kimberly Lezon-Geyda, Peter E. Newburger, Desiree Medeiros, Robin D. Hanson, Jennifer Rothman, Sara Israels, Donna A. Wall, Robert F. Sidonio Jr., Colin Sieff, L. Kate Gowans, Nupur Mittal, Roland Rivera-Santiago, David W. Speicher, Susan J. Baserga, and Vincent P. Schulz
Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression
Emma E. Hornick, Jargalsaikhan Dagvadorj, Zeb R. Zacharias, Ann M. Miller, Ryan A. Langlois, Peter Chen, Kevin L. Legge, Gail A. Bishop, Fayyaz S. Sutterwala, and Suzanne L. Cassel
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury
Wei-Zhong Ying, Xingsheng Li, Sunil Rangarajan, Wenguang Feng, Lisa M. Curtis, Paul W. Sanders
Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
Darja Karpova, Michael P. Rettig, Julie Ritchey, Daniel Cancilla, Stephanie Christ, Leah Gehrs, Ezhilarasi Chendamarai, Moses O. Evbuomwan, Matthew Holt, Jingzhu Zhang, Grazia Abou-Ezzi, Hamza Celik, Eliza Wiercinska, Wei Yang, Feng Gao, Linda G. Eissenberg, Richard F. Heier, Stacy D. Arnett, Marvin J. Meyers, Michael J. Prinsen, David W. Griggs, Andreas Trumpp, Peter G. Ruminski, Dwight M. Morrow, Halvard B. Bonig, Daniel C. Link, and John F. DiPersio
CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs
Ross A. Okimoto, Wei Wu, Shigeki Nanjo, Victor Olivas, Yone K. Lin, Rovingaile Kriska Ponce, Rieko Oyama, Tadashi Kondo, and Trever G. Bivona
Residual β cell function and monogenic variants in long-duration type 1 diabetes patients
Marc Gregory Yu, Hillary A. Keenan, Hetal S. Shah, Scott G. Frodsham, David Pober, Zhiheng He, Emily A. Wolfson, Stephanie D’Eon, Liane J. Tinsley, Susan Bonner-Weir, Marcus G. Pezzolesi, and George Liang King
ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes
G. Michelle Ducasa, Alla Mitrofanova, Shamroop K. Mallela, Xiaochen Liu, Judith Molina, Alexis Sloan, Christopher E. Pedigo, Mengyuan Ge, Javier Varona Santos, Yanio Hernandez, Jin-Ju Kim, Cyrille Maugeais, Armando J. Mendez, Viji Nair, Matthias Kretzler, George W. Burke, Robert G. Nelson, Yu Ishimoto, Reiko Inagi, Santanu Banerjee, Shaoyi Liu, Hazel H. Szeto, Sandra Merscher, Flavia Fontanesi, and Alessia Fornoni
Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer
Nithya Sivaram, Patrick A. McLaughlin, Han V. Han, Oleksi Petrenko, Ya-Ping Jiang, Lisa M. Ballou, Kien Pham, Chen Liu, Adrianus W.M. van der Velden, and Richard Z. Lin
PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice
Ismail Syed, Maria F. Rubin de Celis, James F. Mohan, Pedro M. Moraes-Vieira, Archana Vijayakumar, Andrew T. Nelson, Dionicio Siegel, Alan Saghatelian, Diane Mathis, and Barbara B. Kahn
Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development
Pedro H. Gazzinelli-Guimaraes, Rafael de Queiroz Prado, Alessandra Ricciardi, Sandra Bonne-Année, Joshua Sciurba, Erik P. Karmele, Ricardo T. Fujiwara, and Thomas B. Nutman
Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infections
John I. Robinson, William H. Weir, Jan R. Crowley, Tiffany Hink, Kimberly A. Reske, Jennie H. Kwon, Carey-Ann D. Burnham, Erik R. Dubberke, Peter J. Mucha, and Jeffrey P. Henderson
Human VP8* mAbs neutralize rotavirus selectively in human intestinal epithelial cells
Ningguo Feng, Liya Hu, Siyuan Ding, Mrinmoy Sanyal, Boyang Zhao, Banumathi Sankaran, Sasirekha Ramani, Monica McNeal, Linda L. Yasukawa, Yanhua Song, B.V. Venkataram Prasad, and Harry B. Greenberg
Dectin-2–induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis
Chie Miyabe, Yoshishige Miyabe, Laura Bricio-Moreno, Jeffrey Lian, Rod A. Rahimi, Noriko N. Miura, Naohito Ohno, Yoichiro Iwakura, Tamihiro Kawakami, and Andrew D. Luster
LEAP2 changes with body mass and food intake in humans and mice
Bharath K. Mani, Nancy Puzziferri, Zhenyan He, Juan A. Rodriguez, Sherri Osborne-Lawrence, Nathan P. Metzger, Navpreet Chhina, Bruce Gaylinn, Michael O. Thorner, E. Louise Thomas, Jimmy D. Bell, Kevin W. Williams, Anthony P. Goldstone, and Jeffrey M. Zigman
Tumor cell–intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2)
Nune Markosyan, Jinyang Li, Yu H. Sun, Lee P. Richman, Jeffrey H. Lin, Fangxue Yan, Liz Quinones, Yogev Sela, Taiji Yamazoe, Naomi Gordon, John W. Tobias, Katelyn T. Byrne, Andrew J. Rech, Garret A. FitzGerald, Ben Z. Stanger, and Robert H. Vonderheide
Antibodies targeting sialyl Lewis A mediate tumor clearance through distinct effector pathways
Polina Weitzenfeld, Stylianos Bournazos, and Jeffrey V. Ravetch
mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes
Rami Jaafar, Stella Tran, Ajit N. Shah, Gao Sun, Martin Valdearcos, Piero Marchetti, Matilde Masini, Avital Swisa, Simone Giacometti, Ernesto Bernal-Mizrachi, Aleksey Matveyenko, Matthias Hebrok, Yuval Dor, Guy A. Rutter, Suneil K. Koliwad, and Anil Bhushan
PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms
Peng Zhou, Anna Santoro, Odile D. Peroni, Andrew T. Nelson, Alan Saghatelian, Dionicio Siegel, and Barbara B. Kahn
Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223
Carolina Jimenez Calvente, Masahiko Tameda, Casey D. Johnson, Hana del Pilar, Yun Chin Lin, Nektaria Adronikou, Xavier De Mollerat Du Jeu, Cristina Llorente, Josh Boyer, and Ariel E. Feldstein
Potential role of iron in repair of inflammatory demyelinating lesions
Nathanael J. Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Govind Nair, Nicholas J. Luciano, Emily C. Leibovitch, Cecil C. Yen, Tracey A. Rouault, Afonso C. Silva, Steven Jacobson, and Daniel S. Reich
Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, and Lei Liu
Immune overdrive signature in colorectal tumor subset predicts poor clinical outcome
Marwan Fakih, Ching Ouyang, Chongkai Wang, Travis Yiwey Tu, Maricel C. Gozo, May Cho, Marvin Sy, Jeffrey A. Longmate, and Peter P. Lee
IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
Gang Chen, Ling Sun, Takafumi Kato, Kenichi Okuda, Mary B. Martino, Aiman Abzhanova, Jennifer M. Lin, Rodney C. Gilmore, Bethany D. Batson, Yvonne K. O’Neal, Allison S. Volmer, Hong Dang, Yangmei Deng, Scott H. Randell, Brian Button, Alessandra Livraghi-Butrico, Mehmet Kesimer, Carla M.P. Ribeiro, Wanda K. O’Neal, and Richard C. Boucher
Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Matthew C. Madison, Cameron T. Landers, Bon-Hee Gu, Cheng-Yen Chang, Hui-Ying Tung, Ran You, Monica J. Hong, Nima Baghaei, Li-Zhen Song, Paul Porter, Nagireddy Putluri, Ramiro Salas, Brian E. Gilbert, Ilya Levental, Matthew J. Campen, David B. Corry, and Farrah Kheradmand
Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
Brigitte Laforest, Wenli Dai, Leonid Tyan, Sonja Lazarevic, Kaitlyn M. Shen, Margaret Gadek, Michael T. Broman, Christopher R. Weber, and Ivan P. Moskowitz
Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment
Daniel M. Ramos, Constantin d’Ydewalle, Vijayalakshmi Gabbeta, Amal Dakka, Stephanie K. Klein, Daniel A. Norris, John Matson, Shannon J. Taylor, Phillip G. Zaworski, Thomas W. Prior, Pamela J. Snyder, David Valdivia, Christine L. Hatem, Ian Waters, Nikhil Gupte, Kathryn J. Swoboda, Frank Rigo, C. Frank Bennett, Nikolai Naryshkin, Sergey Paushkin, Thomas O. Crawford, and Charlotte J. Sumner
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma
Paul C. Moore, Jessica T. Cortez, Chester E. Chamberlain, Diana Alba, Amy C. Berger, Zoe Quandt, Alice Chan, Mickie H. Cheng, Jhoanne L. Bautista, Justin Peng, Michael S. German, Mark S. Anderson, and Scott A. Oakes
Increased flux through the mevalonate pathway mediates fibrotic repair without injury
Jennifer L. Larson-Casey, Mudit Vaid, Linlin Gu, Chao He, Guo-Qiang Cai, Qiang Ding, Dana Davis, Taylor F. Berryhill, Landon S. Wilson, Stephen Barnes, Jeffrey D. Neighbors, Raymond J. Hohl, Kurt A. Zimmerman, Bradley K. Yoder, Ana Leda F. Longhini, Vidya Sagar Hanumanthu, Ranu Surolia, Veena B. Antony, and A. Brent Carter
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation
W. Brian Dalton, Eric Helmenstine, Noel Walsh, Lukasz P. Gondek, Dhanashree S. Kelkar, Abigail Read, Rachael Natrajan, Eric S. Christenson, Barbara Roman, Samarjit Das, Liang Zhao, Robert D. Leone, Daniel Shinn, Taylor Groginski, Anil K. Madugundu, Arun Patil, Daniel J. Zabransky, Arielle Medford, Justin Lee, Alex J. Cole, Marc Rosen, Maya Thakar, Alexander Ambinder, Joshua Donaldson, Amy E. DeZern, Karen Cravero, David Chu, Rafael Madero-Marroquin, Akhilesh Pandey, Paula J. Hurley, Josh Lauring, and Ben Ho Park
Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis
Ji-Yeon Shin, Antonio Hernandez-Ono, Tatyana Fedotova, Cecilia Östlund, Michael J. Lee, Sarah B. Gibeley, Chun-Chi Liang, William T. Dauer, Henry N. Ginsberg, and Howard J. Worman
Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans
Kitt Falk Petersen, Sylvie Dufour, Gary W. Cline, and Gerald I. Shulman
Recombinant annexin A6 promotes membrane repair and protects against muscle injury
Alexis R. Demonbreun, Katherine S. Fallon, Claire C. Oosterbaan, Elena Bogdanovic, James L. Warner, Jordan J. Sell, Patrick G. Page, Mattia Quattrocelli, David Y. Barefield, and Elizabeth M. McNally
Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses
Seiji Kishi, Craig R. Brooks, Kensei Taguchi, Takaharu Ichimura, Yutaro Mori, Akinwande Akinfolarin, Navin Gupta, Pierre Galichon, Bertha C. Elias, Tomohisa Suzuki, Qian Wang, Leslie Gewin, Ryuji Morizane, and Joseph V. Bonventre
High-fat diet exacerbates SIV pathogenesis and accelerates disease progression
Tianyu He, Cuiling Xu, Noah Krampe, Stephanie M. Dillon, Paola Sette, Elizabeth Falwell, George S. Haret-Richter, Tiffany Butterfield, Tammy L. Dunsmore, William M. McFadden Jr., Kathryn J. Martin, Benjamin B. Policicchio, Kevin D. Raehtz, Ellen P. Penn, Russell P. Tracy, Ruy M. Ribeiro, Daniel N. Frank, Cara C. Wilson, Alan L. Landay, Cristian Apetrei, and Ivona Pandrea
Slowing ribosome velocity restores folding and function of mutant CFTR
Kathryn E. Oliver, Robert Rauscher, Marjolein Mijnders, Wei Wang, Matthew J. Wolpert, Jessica Maya, Carleen M. Sabusap, Robert A. Kesterson, Kevin L. Kirk, Andras Rab, Ineke Braakman, Jeong S. Hong, John L. Hartman IV, Zoya Ignatova, and Eric J. Sorscher
Expression of mitochondrial membrane–linked SAB determines severity of sex-dependent acute liver injury
Sanda Win, Robert W.M. Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, Manal F. Abdelmalek, Ying Wang, Mariam Aghajan, Filbert W.M. Aung, Anna Mae Diehl, Roger J. Davis, Tin A. Than, and Neil Kaplowitz
FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury
Monica Chang-Panesso, Farid F. Kadyrov, Matthew Lalli, Haojia Wu, Shiyo Ikeda, Eirini Kefaloyianni, Mai M. Abdelmageed, Andreas Herrlich, Akio Kobayashi, and Benjamin D. Humphreys
Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment
Amy J. Petty, Ang Li, Xinyi Wang, Rui Dai, Benjamin Heyman, David Hsu, Xiaopei Huang, and Yiping Yang
Hemodynamic regulation of perivalvular endothelial gene expression prevents deep thrombosis
John D. Welsh, Mark H. Hoofnagle, Sharika Bamezai, Michael Oxendine, Lillian Lim, Joshua D. Hall, Jisheng Yang, Susan Schultz, James Douglas Engel, Tsutomu Kume, Guillermo Oliver, Juan M. Jimenez, and Mark L. Kahn

JCI Insight Editor’s Update, December 2019

Posted on by Maya Hoptman

Dear Colleague,

I am pleased to be sending you this first update as Editor of JCI Insight. Along with Deputy Editors Andrew Lieberman, Donna Martin, and Pavan Reddy, we have seamlessly transitioned the journal to a new Editorial Board. The Board represents the breadth of expertise that is a hallmark of the ASCI membership and meets in person weekly to discuss manuscripts under consideration. JCI Insight continues to publish translational and early-phase clinical studies in all disciplines of biomedical research, and many have attracted considerable attention in the academic and lay press, as well as social media (see below). In particular, the Journal published 39 Clinical Medicine articles in 2019, in areas such as infectious disease, immunology, cardiology, metabolism, neuroscience, dermatology, and otology.

This year, we initiated the JCI Insight Scholars program, in which Board members provide mentorship and training in academic peer review and editorship to young physician-scientists. Andrea D. Thompson, a cardiology fellow at the University of Michigan, is the first to hold this position; the next cohort of Scholars will begin in February 2020. Also focusing on the physician-scientist experience, the journal recently published two Perspective articles on the national MD-PhD program outcomes study.

A few reminders:

  • Authors can transfer their bioRxiv manuscripts for consideration by JCI Insight.
  • Insight offers authors the opportunity to publish accepted submissions as In-Press Previews.
  • Authors can provide graphical abstracts as well as video overviews of their work to accompany their published articles.
  • Any dues-paying ASCI member who is a corresponding author of a first-round submission to JCI Insight, and whose dues are current, may designate up to three submissions per calendar year to be guaranteed for external peer review.

We look forward to the New Year and the opportunities it brings for reviewing our first several months on the job and developing new initiatives. We welcome any input and suggestions, and encourage you to consider JCI Insight as a venue for your work.

Sincerely,
Kathleen L. Collins, MD, PhD
Editor, JCI Insight

Social media activity: Twitter

Source: Altmetric, November 2019.

Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss
Clinical Medicine
Parker N. Hyde, Teryn N. Sapper, Christopher D. Crabtree, Richard A. LaFountain, Madison L. Bowling, Alex Buga, Brandon Fell, Fionn T. McSwiney, Ryan M. Dickerson, Vincent J. Miller, Debbie Scandling, Orlando P. Simonetti, Stephen D. Phinney, William J. Kraemer, Sarah A. King, Ronald M. Krauss, and Jeff S. Volek

Twitter mentions: 736

The national MD-PhD program outcomes study: relationships between medical specialty, training duration, research effort, and career paths
Perspective
Lawrence F. Brass and Myles H. Akabas

Twitter mentions: 236

Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery
Research
Dale S. Edgerton, Melanie Scott, Ben Farmer, Phillip E. Williams, Peter Madsen, Thomas Kjeldsen, Christian L. Brand, Christian Fledelius, Erica Nishimura, and Alan D. Cherrington

Twitter mentions: 122

Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer
Research
Meifang Yu, Nicholas D. Nguyen, Yanqing Huang, Daniel Lin, Tara N. Fujimoto, Jessica M. Molkentine, Amit Deorukhkar, Ya’an Kang, F. Anthony San Lucas, Conrad J. Fernandes, Eugene J. Koay, Sonal Gupta, Haoqiang Ying, Albert C. Koong, Joseph M. Herman, Jason B. Fleming, Anirban Maitra, and Cullen M. Taniguchi

Twitter mentions: 119

JCI Insight in selected news outlets

Source: Altmetric. Corresponding authors who are ASCI members are indicated in bold.

Phase 2a randomized, placebo-controlled study of anti–IL-33 in peanut allergy
Clinical Medicine
Sharon Chinthrajah, Shu Cao, Cherie Liu, Shu-Chen Lyu, Sayantani B. Sindher, Andrew Long, Vanitha Sampath, Daniel Petroni, Marco Londei, and Kari C. Nadeau

Mentioned in CNN Health, Detroit Free Press

Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity
Research
Joel Castro, Andrea M. Harrington, TinaMarie Lieu, Sonia Garcia-Caraballo, Jessica Maddern, Gudrun Schober, Tracey O’Donnell, Luke Grundy, Amanda L. Lumsden, Paul Miller, Andre Ghetti, Martin S. Steinhoff, Daniel P. Poole, Xinzhong Dong, Lin Chang, Nigel W. Bunnett, and Stuart M. Brierley

Mentioned in Newsweek

Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss
Clinical Medicine
Parker N. Hyde, Teryn N. Sapper, Christopher D. Crabtree, Richard A. LaFountain, Madison L. Bowling, Alex Buga, Brandon Fell, Fionn T. McSwiney, Ryan M. Dickerson, Vincent J. Miller, Debbie Scandling, Orlando P. Simonetti, Stephen D. Phinney, William J. Kraemer, Sarah A. King, Ronald M. Krauss, and Jeff S. Volek

Mentioned in Vox.com

Highest-cited research published in 2019

Source: Web of Science as of December 5, 2019. Corresponding authors who are ASCI members are indicated in bold.

PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers
Clinical Medicine
Mark Yarchoan, Lee A. Albacker, Alexander C. Hopkins, Meagan Montesion, Karthikeyan Murugesan, Teena T. Vithayathil, Neeha Zaidi, Nilofer S. Azad, Daniel A. Laheru, Garrett M. Frampton, and Elizabeth M. Jaffee

Times cited: 11

Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement
Research
Douglas B. Johnson, Mellissa J. Nixon, Yu Wang, Daniel Y. Wang, Emily Castellanos, Monica V. Estrada, Paula I. Ericsson-Gonzalez, Candace H. Cote, Roberto Salgado, Violeta Sanchez, Phillip T. Dean, Susan R. Opalenik, Daniel M. Schreeder, David L. Rimm, Ju Young Kim, Jennifer Bordeaux, Sherene Loi, Leora Horn, Melinda E. Sanders, P. Brent Ferrell Jr., Yaomin Xu, Jeffrey A. Sosman, Randall S. Davis, and Justin M. Balko

Times cited: 11

Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma
Research
Yana G. Najjar, Ashley V. Menk, Cindy Sander, Uma Rao, Arivarasan Karunamurthy, Roma Bhatia, Shuyan Zhai, John M. Kirkwood, and Greg M. Delgoffe

Times cited: 9

Effect of ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis patients with G551D-CFTR
Clinical Medicine
Scott H. Donaldson, Beth L. Laube, Timothy E. Corcoran, Pradeep Bhambhvani, Kirby Zeman, Agathe Ceppe, Pamela L. Zeitlin, Peter J. Mogayzel Jr., Michael Boyle, Landon W. Locke, Michael M. Myerburg, Joseph M. Pilewski, Brian Flanagan, Steven M. Rowe, and William D. Bennett

Times cited: 8

Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases
Research
Camille M. Syrett, Bam Paneru, Donavon Sandoval-Heglund, Jianle Wang, Sarmistha Banerjee, Vishal Sindhava, Edward M. Behrens, Michael Atchison, and Montserrat C. Anguera

Times cited: 7

Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets
Research
Kara J. Mould, Nathan D. Jackson, Peter M. Henson, Max Seibold, and William J. Janssen

Times cited: 7

Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis
Research
Donny Hanjaya-Putra, Carolyn Haller, Xiaowei Wang, Erbin Dai, Bock Lim, Liying Liu, Patrick Jaminet, Joy Yao, Amy Searle, Thomas Bonnard, Christoph E. Hagemeyer, Karlheinz Peter, and Elliot L. Chaikof

Times cited: 7

JCI Insight research with ASCI members as corresponding authors, 2019

Organoid single cell profiling identifies a transcriptional signature of glomerular disease
Jennifer L. Harder, Rajasree Menon, Edgar A. Otto, Jian Zhou, Sean Eddy, Noel L. Wys, Christopher O’Connor, Jinghui Luo, Viji Nair, Cristina Cebrian, Jason R. Spence, Markus Bitzer, Olga G. Troyanskaya, Jeffrey B. Hodgin, Roger C. Wiggins, Benjamin S. Freedman, Matthias Kretzler, and the European Renal cDNA Bank (ERCB), Nephrotic Syndrome Study Network (NEPTUNE)
Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function
Man Liu, Euy-Myoung Jeong, Hong Liu, An Xie, Eui Young So, Guangbin Shi, Go Eun Jeong, Anyu Zhou, and Samuel C. Dudley Jr.
Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma
Pablo Vieyra-Garcia, Jack D. Crouch, John T. O’Malley, Edward W. Seger, Chao H. Yang, Jessica E. Teague, Anna Maria Vromans, Ahmed Gehad, Thet Su Win, Zizi Yu, Elizabeth L. Lowry, Jung-Im Na, Alain H. Rook, Peter Wolf, and Rachael A. Clark
Microbiota-dependent signals are required to sustain TLR-mediated immune responses
Lehn K. Weaver, Danielle Minichino, Chhanda Biswas, Niansheng Chu, Jung-Jin Lee, Kyle Bittinger, Sabrin Albeituni, Kim E. Nichols, and Edward M. Behrens
Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis
Jeremy Herrera, Colleen Forster, Thomas Pengo, Angeles Montero, Joe Swift, Martin A. Schwartz, Craig A. Henke, and Peter B. Bitterman
One-year pilot study on the effects of nitisinone on melanin in patients with OCA-1B
David R. Adams, Supriya Menezes, Ramon Jauregui, Zaheer M. Valivullah, Bradley Power, Maria Abraham, Brett G. Jeffrey, Angel Garced, Ramakrishna P. Alur, Denise Cunningham, Edythe Wiggs, Melissa A. Merideth, Pei-Wen Chiang, Shanna Bernstein, Shosuke Ito, Kazumasa Wakamatsu, Rhona M. Jack, Wendy J. Introne, William A. Gahl, and Brian P. Brooks
Mycophenolate mofetil reduces STAT-3 phosphorylation in systemic lupus erythematosus patients
Samantha Slight-Webb, Joel M. Guthridge, Eliza F. Chakravarty, Hua Chen, Rufei Lu, Susan Macwana, Krista Bean, Holden T. Maecker, Paul J. Utz, and Judith A. James
Macrophage IFN-I signaling promotes autoreactive T cell infiltration into islets in type 1 diabetes model
Brett S. Marro, Sarah Legrain, Brian C. Ware, and Michael B.A. Oldstone
Resident macrophages reprogram toward a developmental state after acute kidney injury
Jeremie M. Lever, Travis D. Hull, Ravindra Boddu, Mark E. Pepin, Laurence M. Black, Oreoluwa O. Adedoyin, Zhengqin Yang, Amie M. Traylor, Yanlin Jiang, Zhang Li, Jacelyn E. Peabody, Hannah E. Eckenrode, David K. Crossman, Michael R. Crowley, Subhashini Bolisetty, Kurt A. Zimmerman, Adam R. Wende, Michal Mrug, Bradley K. Yoder, Anupam Agarwal, and James F. George
Inhibition of B cell–dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation
Natalia F. Smirnova, Thomas M. Conlon, Carmela Morrone, Peter Dorfmuller, Marc Humbert, Georgios T. Stathopoulos, Stephan Umkehrer, Franz Pfeiffer, Ali Ö. Yildirim, and Oliver Eickelberg
Excess growth hormone suppresses DNA damage repair in epithelial cells
Vera Chesnokova, Svetlana Zonis, Robert Barrett, Hiraku Kameda, Kolja Wawrowsky, Anat Ben-Shlomo, Masaaki Yamamoto, John Gleeson, Catherine Bresee, Vera Gorbunova, and Shlomo Melmed
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense
Julie L. Horton, Michael T. Davidson, Clara Kurishima, Rick B. Vega, Jeffery C. Powers, Timothy R. Matsuura, Christopher Petucci, E. Douglas Lewandowski, Peter A. Crawford, Deborah M. Muoio, Fabio A. Recchia, and Daniel P. Kelly
PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells
Masato Mashimo, Xiangning Bu, Kazumasa Aoyama, Jiro Kato, Hiroko Ishiwata-Endo, Linda A. Stevens, Atsushi Kasamatsu, Lynne A. Wolfe, Camilo Toro, David Adams, Thomas Markello, William A. Gahl, and Joel Moss
Direct activation of PP2A for the treatment of tyrosine kinase inhibitor–resistant lung adenocarcinoma
Rita Tohmé, Sudeh Izadmehr, Sai Gandhe, Giancarlo Tabaro, Sanjay Vallabhaneni, Ava Thomas, Neal Vasireddi, Neil S. Dhawan, Avi Ma’ayan, Neelesh Sharma, Matthew D. Galsky, Michael Ohlmeyer, Jaya Sangodkar, and Goutham Narla
Skin sympathetic nerve activity and the temporal clustering of cardiac arrhythmias
Takashi Kusayama, Juyi Wan, Anisiia Doytchinova, Johnson Wong, Ryan A. Kabir, Gloria Mitscher, Susan Straka, Changyu Shen, Thomas H. Everett IV, and Peng-Sheng Chen
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea
Tianying Duan, Onur Cil, Jay R. Thiagarajah, and Alan S. Verkman
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
Shigeki Nishimori, Forest Lai, Mieno Shiraishi, Tatsuya Kobayashi, Elena Kozhemyakina, Tso-Pang Yao, Andrew B. Lassar, and Henry M. Kronenberg
Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease
Jinfeng Yang, Abdulraouf Ramadan, Dawn K. Reichenbach, Michael Loschi, Jilu Zhang, Brad Griesenauer, Hong Liu, Keli L. Hippen, Bruce R. Blazar, and Sophie Paczesny
TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons
Runping Wang, Yongjun Lu, Michael Z. Cicha, Madhu V. Singh, Christopher J. Benson, Christopher J. Madden, Mark W. Chapleau, and François M. Abboud
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms
Soravis Osataphan, Chiara Macchi, Garima Singhal, Jeremy Chimene-Weiss, Vicencia Sales, Chisayo Kozuka, Jonathan M. Dreyfuss, Hui Pan, Yanin Tangcharoenpaisan, Jordan Morningstar, Robert Gerszten, and Mary-Elizabeth Patti
Propionibacterium acnes–induced immunopathology correlates with health and disease association
Stacey L. Kolar, Chih-Ming Tsai, Juan Torres, Xuemo Fan, Huiying Li, and George Y. Liu
Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes
Ellis Y. Kim, David Y. Barefield, Andy H. Vo, Anthony M. Gacita, Emma J. Schuster, Eugene J. Wyatt, Janel L. Davis, Biqin Dong, Cheng Sun, Patrick Page, Lisa Dellefave-Castillo, Alexis Demonbruen, Hao F. Zhang, and Elizabeth M. McNally
IL-33–mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury
Quan Liu, Gaelen K. Dwyer, Yifei Zhao, Huihua Li, Lisa R. Mathews, Anish Bhaswantha Chakka, Uma R. Chandran, Jake A. Demetris, John F. Alcorn, Keven M. Robinson, Luis A. Ortiz, Bruce R. Pitt, Angus W. Thomson, Ming-Hui Fan, Timothy R. Billiar, and Hēth R. Turnquist
Transcriptional analysis of Foxp3+ Tregs and functions of two identified molecules during resolution of ALI
Jason R. Mock, Catherine F. Dial, Miriya K. Tune, Dustin L. Norton, Jessica R. Martin, John C. Gomez, Robert S. Hagan, Hong Dang, and Claire M. Doerschuk
PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis
Yan Geng, Xue Liu, Jiurong Liang, David Habiel, Kulur Vrishika, Ana Lucia Coelho, Nan Deng, Ting Xie, Yizhou Wang, Ningshan Liu, Guanling Huang, Adrianne Kurkciyan, Zhenqiu Liu, Jie Tang, Cory Hogaboam, Dianhua Jiang, and Paul W. Noble
Myeloid folliculin balances mTOR activation to maintain innate immunity homeostasis
Jia Li, Shogo Wada, Lehn K. Weaver, Chhanda Biswas, Edward M. Behrens, and Zoltan Arany
Definition of a multiple myeloma progenitor population in mice driven by enforced expression of XBP1s
Joshua Kellner, Caroline Wallace, Bei Liu, and Zihai Li
Exogenous sickle erythrocytes combined with vascular disruption trigger disseminated tumor vaso-occlusion and lung tumor regression
Chiao-Wang Sun, Li-Chen Wu, Mamta Wankhede, Dezhi Wang, Jutta Thoerner, Lawrence Woody, Brian S. Sorg, Tim M. Townes, and David S. Terman
Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice
Russell G. Rogers, Mario Fournier, Lizbeth Sanchez, Ahmed G. Ibrahim, Mark A. Aminzadeh, Michael I. Lewis, and Eduardo Marbán
Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC
Guoxin Zhang, Zhen Dong, Briana C. Prager, Leo J.K. Kim, Qiulian Wu, Ryan C. Gimple, Xiuxing Wang, Shideng Bao, Petra Hamerlik, and Jeremy N. Rich
Human duct cells contribute to β cell compensation in insulin resistance
Ercument Dirice, Dario F. De Jesus, Sevim Kahraman, Giorgio Basile, Raymond W.S. Ng, Abdelfattah El Ouaamari, Adrian Kee Keong Teo, Shweta Bhatt, Jiang Hu, and Rohit N. Kulkarni
A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus
Courtney M. Fernandez-Petty, Gareth W. Hughes, Hannah L. Bowers, John D. Watson, Bradley H. Rosen, Stacy M. Townsend, Carlo Santos, Caroline E. Ridley, Kengyeh K. Chu, Susan E. Birket, Yao Li, Hui Min Leung, Marina Mazur, Bryan A. Garcia, T. Idil Apak Evans, Emily Falk Libby, Heather Hathorne, Justin Hanes, Guillermo J. Tearney, John P. Clancy, John F. Engelhardt, William E. Swords, David J. Thornton, William P. Wiesmann, Shenda M. Baker, and Steven M. Rowe
Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies
Terisse A. Brocato, Ursa Brown-Glaberman, Zhihui Wang, Reed G. Selwyn, Colin M. Wilson, Edward F. Wyckoff, Lesley C. Lomo, Jennifer L. Saline, Anupama Hooda-Nehra, Renata Pasqualini, Wadih Arap, C. Jeffrey Brinker, and Vittorio Cristini
Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsiesTFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance
Matthew R. Lynch, Mei T. Tran, Kenneth M. Ralto, Zsuzsanna K. Zsengeller, Vinod Raman, Swati S. Bhasin, Nuo Sun, Xiuying Chen, Daniel Brown, Ilsa I. Rovira, Kensei Taguchi, Craig R. Brooks, Isaac E. Stillman, Manoj K. Bhasin, Toren Finkel, and Samir M. Parikh
Autophagy links antimicrobial activity with antigen presentation in Langerhans cells
Angeline Tilly Dang, Rosane M.B. Teles, Phillip T. Liu, Aaron Choi, Annalisa Legaspi, Euzenir N. Sarno, Maria T. Ochoa, Kislay Parvatiyar, Genhong Cheng, Michel Gilliet, Barry R. Bloom, and Robert L. Modlin
Safety and tolerability of conditioning chemotherapy followed by CD19-targeted CAR T cells for relapsed/refractory CLL
Mark B. Geyer, Isabelle Rivière, Brigitte Sénéchal, Xiuyan Wang, Yongzeng Wang, Terence J. Purdon, Meier Hsu, Sean M. Devlin, M. Lia Palomba, Elizabeth Halton, Yvette Bernal, Dayenne G. van Leeuwen, Michel Sadelain, Jae H. Park, and Renier J. Brentjens
Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis
Edward J. Schenck, Kevin C. Ma, David R. Price, Thomas Nicholson, Clara Oromendia, Eliza Rose Gentzler, Elizabeth Sanchez, Rebecca M. Baron, Laura E. Fredenburgh, Jin-Won Huh, Ilias I. Siempos, and Augustine M.K. Choi
Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin-1B
Benjamin J. Frisch, Corey M. Hoffman, Sarah E. Latchney, Mark W. LaMere, Jason Myers, John Ashton, Allison J. Li, Jerry Saunders II, James Palis, Archibald S. Perkins, Amanda McCabe, Julianne N.P. Smith, Kathleen E. McGrath, Fatima Rivera-Escalera, Andrew McDavid, Jane L. Liesveld, Vyacheslav A. Korshunov, Michael R. Elliott, Katherine C. MacNamara, Michael W. Becker, and Laura M. Calvi
Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation
Jeffrey J. Hsu, Vijay Vedula, Kyung In Baek, Cynthia Chen, Junjie Chen, Man In Chou, Jeffrey Lam, Shivani Subhedar, Jennifer Wang, Yichen Ding, Chih-Chiang Chang, Juhyun Lee, Linda L. Demer, Yin Tintut, Alison L. Marsden, and Tzung K. Hsiai
Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions
Guangrui Yang, Lihong Chen, Jiayang Zhang, Baoyin Ren, and Garret A. FitzGerald
TLR9/MyD88/TRIF signaling activates host immune inhibitory CD200 in Leishmania infection
Ismael P. Sauter, Katerine G. Madrid, Josiane B. de Assis, Anderson Sá-Nunes, Ana C. Torrecilhas, Daniela I. Staquicini, Renata Pasqualini, Wadih Arap, and Mauro Cortez
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Dennis G. Moledina, F. Perry Wilson, Jordan S. Pober, Mark A. Perazella, Nikhil Singh, Randy L. Luciano, Wassim Obeid, Haiqun Lin, Michael Kuperman, Gilbert W. Moeckel, Michael Kashgarian, Lloyd G. Cantley, and Chirag R. Parikh
Tertiary lymphoid structures in the choroid plexus in neuropsychiatric lupus
Ariel D. Stock, Evan Der, Sivan Gelb, Michelle Huang, Karen Weidenheim, Ayal Ben-Zvi, and Chaim Putterman
Down syndrome mouse models have an abnormal enteric nervous system
Ellen M. Schill, Christina M. Wright, Alisha Jamil, Jonathan M. LaCombe, Randall J. Roper, and Robert O. Heuckeroth
Early alterations in stem-like/marrow-resident T cells and innate and myeloid cells in preneoplastic gammopathy
Jithendra Kini Bailur, Samuel S. McCachren, Deon B. Doxie, Mahesh Shrestha, Katherine Pendleton, Ajay K. Nooka, Natalia Neparidze, Terri L. Parker, Noffar Bar, Jonathan L. Kaufman, Craig C. Hofmeister, Lawrence H. Boise, Sagar Lonial, Melissa L. Kemp, Kavita M. Dhodapkar, and Madhav V. Dhodapkar
Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction
Oscar Okwudiri Onyema, Yizhan Guo, Bayan Mahgoub, Qing Wang, Amir Manafi, Zhongcheng Mei, Anirban Banerjee, Dongge Li, Mark H. Stoler, Melissa T. Zaidi, Adam G. Schrum, Daniel Kreisel, Andrew E. Gelman, Elizabeth A. Jacobsen, and Alexander Sasha Krupnick
Robust surgical approach for cutaneous neurofibroma in neurofibromatosis type 1
Bahir H. Chamseddin, La’Nette Hernandez, Dezehree Solorzano, Juan Vega, and Lu Q. Le
Functional methylome analysis of human diabetic kidney disease
Jihwan Park, Yuting Guan, Xin Sheng, Caroline Gluck, Matthew J. Seasock, A. Ari Hakimi, Chengxiang Qiu, James Pullman, Amit Verma, Hongzhe Li, Matthew Palmer, and Katalin Susztak
PARP-1 controls NK cell recruitment to the site of viral infection
Qiyang Shou, Huiying Fu, Xiaopei Huang, and Yiping Yang
Protective role of B cells in sterile particulate–induced lung injury
Shaikh M. Atif, Douglas G. Mack, Amy S. McKee, Javier Rangel-Moreno, Allison K. Martin, Andrew Getahun, Lisa A. Maier, John C. Cambier, Rubin Tuder, and Andrew P. Fontenot
Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity
Shenqiu Wang, Sayan Mondal, Chunying Zhao, Marjan Berishaj, Phani Ghanakota, Connie Lee Batlevi, Ahmet Dogan, Venkatraman E. Seshan, Robert Abel, Michael R. Green, Anas Younes, and Hans-Guido Wendel
Genomic analysis of benign prostatic hyperplasia implicates cellular relandscaping in disease pathogenesis
Lance W. Middleton, Zhewei Shen, Sushama Varma, Anna S. Pollack, Xue Gong, Shirley Zhu, Chunfang Zhu, Joseph W. Foley, Sujay Vennam, Robert T. Sweeney, Karen Tu, Jewison Biscocho, Okyaz Eminaga, Rosalie Nolley, Robert Tibshirani, James D. Brooks, Robert B. West, and Jonathan R. Pollack
Cigarette smoke–induced reduction of C1q promotes emphysema
Xiaoyi Yuan, Cheng-Yen Chang, Ran You, Ming Shan, Bon Hee Gu, Matthew C. Madison, Gretchen Diehl, Sarah Perusich, Li-Zhen Song, Lorraine Cornwell, Roger D. Rossen, Rick Wetsel, Rajapakshe Kimal, Cristian Coarfa, Holger K. Eltzschig, David B. Corry, and Farrah Kheradmand
Vitamin D–regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification
Loan Nguyen-Yamamoto, Ken-Ichiro Tanaka, Rene St-Arnaud, and David Goltzman
Landscape of innate immune system transcriptome and acute T cell–mediated rejection of human kidney allografts
Franco B. Mueller, Hua Yang, Michelle Lubetzky, Akanksha Verma, John R. Lee, Darshana M. Dadhania, Jenny Z. Xiang, Steven P. Salvatore, Surya V. Seshan, Vijay K. Sharma, Olivier Elemento, Manikkam Suthanthiran, and Thangamani Muthukumar
Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma
Chang-Lung Lee, Yvonne M. Mowery, Andrea R. Daniel, Dadong Zhang, Alexander B. Sibley, Joe R. Delaney, Amy J. Wisdom, Xiaodi Qin, Xi Wang, Isibel Caraballo, Jeremy Gresham, Lixia Luo, David Van Mater, Kouros Owzar, and David G. Kirsch
Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis
Davide Povero, Eva M. Pinatel, Aleksandra Leszczynska, Nidhi P. Goyal, Takahiro Nishio, Jihoon Kim, David Kneiber, Lucas de Araujo Horcel, Akiko Eguchi, Paulina M. Ordonez, Tatiana Kisseleva, and Ariel E. Feldstein
TAZ is required for lung alveolar epithelial cell differentiation after injury
Tianhe Sun, Zhiyu Huang, Hua Zhang, Clara Posner, Guiquan Jia, Thirumalai R. Ramalingam, Min Xu, Hans Brightbill, Jackson G. Egen, Anwesha Dey, and Joseph R. Arron
Hyperactivity of factor IX Padua (R338L) depends on factor VIIIa cofactor activity
Benjamin J. Samelson-Jones, Jonathan D. Finn, Lindsey A. George, Rodney M. Camire, and Valder R. Arruda
Immunomodulatory role of nonneuronal cholinergic signaling in myocardial injury
Cibele Rocha-Resende, Carla Weinheimer, Geetika Bajpai, Luigi Adamo, Scot J. Matkovich, Joel Schilling, Philip M. Barger, Kory J. Lavine, and Douglas L. Mann
Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor
Michael V. Ortiz, Saima Ahmed, Melissa Burns, Anton G. Henssen, Travis J. Hollmann, Ian MacArthur, Shehana Gunasekera, Lyvia Gaewsky, Gary Bradwin, Jeremy Ryan, Anthony Letai, Ying He, Arlene Naranjo, Yueh-Yun Chi, Michael LaQuaglia, Todd Heaton, Paolo Cifani, Jeffrey S. Dome, Samantha Gadd, Elizabeth Perlman, Elizabeth Mullen, Hanno Steen, and Alex Kentsis
Skin-restricted commensal colonization accelerates skin graft rejection
Yuk Man Lei, Martin Sepulveda, Luqiu Chen, Ying Wang, Isabella Pirozzolo, Betty Theriault, Anita S. Chong, Yasmine Belkaid, and Maria-Luisa Alegre
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
Maria Plataki, LiChao Fan, Elizabeth Sanchez, Ziling Huang, Lisa K. Torres, Mitsuru Imamura, Yizhang Zhu, David E. Cohen, Suzanne M. Cloonan, and Augustine M.K. Choi
Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma
Nilay Sethi, Osamu Kikuchi, James McFarland, Yanxi Zhang, Max Chung, Nicholas Kafker, Mirazul Islam, Benjamin Lampson, Abhishek Chakraborty, William G. Kaelin Jr., and Adam J. Bass
MondoA drives muscle lipid accumulation and insulin resistance
Byungyong Ahn, Shibiao Wan, Natasha Jaiswal, Rick B. Vega, Donald E. Ayer, Paul M. Titchenell, Xianlin Han, Kyoung Jae Won, and Daniel P. Kelly
NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis
Chao He, Jennifer L. Larson-Casey, Dana Davis, Vidya Sagar Hanumanthu, Ana Leda F. Longhini, Victor J. Thannickal, Linlin Gu, and A. Brent Carter
Computational modeling reveals multiple abnormalities of myocardial noradrenergic function in Lewy body diseases
David S. Goldstein, Mark J. Pekker, Graeme Eisenhofer, and Yehonatan Sharabi
A G protein–coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23
Qing He, Lauren T. Shumate, Julia Matthias, Cumhur Aydin, Marc N. Wein, Jordan M. Spatz, Regina Goetz, Moosa Mohammadi, Antonius Plagge, Paola Divieti Pajevic, and Murat Bastepe
High-fat diet–induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel
Gintautas Grabauskas, Xiaoyin Wu, ShiYi Zhou, JiYao Li, Jun Gao, and Chung Owyang
Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis
Qian Wang, Kazuhiro Onuma, Changhao Liu, Heidi Wong, Michelle S. Bloom, Eileen E. Elliott, Richard R.L. Cao, Nick Hu, Nithya Lingampalli, Orr Sharpe, Xiaoyan Zhao, Dong Hyun Sohn, Christin M. Lepus, Jeremy Sokolove, Rong Mao, Cecilia T. Cisar, Harini Raghu, Constance R. Chu, Nicholas J. Giori, Stephen B. Willingham, Susan S. Prohaska, Zhen Cheng, Irving L. Weissman, and William H. Robinson
Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys
Niranjana Natarajan, Ana Vujic, Jishnu Das, Annie C. Wang, Krystal K. Phu, Spencer H. Kiehm, Elisabeth M. Ricci-Blair, Anthony Y. Zhu, Kelli L. Vaughan, Ricki J. Colman, Julie A. Mattison, and Richard T. Lee
Adoptive lymphocyte transfer to an HIV-infected progressor from an elite controller
Stephen A. Migueles, Cheryl Chairez, Siying Lin, Noah V. Gavil, Danielle M. Rosenthal, Milad Pooran, Ven Natarajan, Adam Rupert, Robin Dewar, Tauseef Rehman, Brad T. Sherman, Joseph Adelsberger, Susan F. Leitman, David Stroncek, Caryn G. Morse, Mark Connors, H. Clifford Lane, and Joseph A. Kovacs
Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain
Gregory N. Ruegsegger, Patrick M. Vanderboom, Surendra Dasari, Katherine A. Klaus, Parijat Kabiraj, Christina B. McCarthy, Claudia F. Lucchinetti, and K. Sreekumaran Nair
Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality
Asim Saha, Patricia A. Taylor, Christopher J. Lees, Angela Panoskaltsis-Mortari, Mark J. Osborn, Colby J. Feser, Govindarajan Thangavelu, Wolfgang Melchinger, Yosef Refaeli, Geoffrey R. Hill, David H. Munn, William J. Murphy, Jonathan S. Serody, Ivan Maillard, Katharina Kreymborg, Marcel van den Brink, Chen Dong, Shuyu Huang, Xingxing Zang, James P. Allison, Robert Zeiser, and Bruce R. Blazar
HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia
Jingyu Xiang, Daniel A. Rauch, Devra D. Huey, Amanda R. Panfil, Xiaogang Cheng, Alison K. Esser, Xinming Su, John C. Harding, Yalin Xu, Gregory C. Fox, Francesca Fontana, Takayuki Kobayashi, Junyi Su, Hemalatha Sundaramoorthi, Wing Hing Wong, Yizhen Jia, Thomas J. Rosol, Deborah J. Veis, Patrick L. Green, Stefan Niewiesk, Lee Ratner, and Katherine N. Weilbaecher
Resident memory CD8+ T cells within cancer islands mediate survival in breast cancer patients
Colt A. Egelston, Christian Avalos, Travis Y. Tu, Anthony Rosario, Roger Wang, Shawn Solomon, Gayathri Srinivasan, Michael S. Nelson, Yinghui Huang, Min Hui Lim, Diana L. Simons, Ting-Fang He, John H. Yim, Laura Kruper, Joanne Mortimer, Susan Yost, Weihua Guo, Christopher Ruel, Paul H. Frankel, Yuan Yuan, and Peter P. Lee
Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice
Yazmin I. Rovira Gonzalez, Adam L. Moyer, Nicolas J. LeTexier, August D. Bratti, Siyuan Feng, Congshan Sun, Ting Liu, Jyothi Mula, Pankhuri Jha, Shama R. Iyer, Richard Lovering, Brian O’Rourke, Hye Lim Noh, Sujin Suk, Jason K. Kim, George K. Essien Umanah, and Kathryn R. Wagner
MicroRNA-7a overexpression in VMH restores the sympathoadrenal response to hypoglycemia
Rahul Agrawal, Griffin Durupt, Dinesh Verma, Michael Montgomery, Adriana Vieira-de Abreu, Casey Taylor, Sankar Swaminathan, and Simon J. Fisher
Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics
Jennifer M. Speth, Loka R. Penke, Joseph D. Bazzill, Kyung Soo Park, Rafael Gil de Rubio, Daniel J. Schneider, Hideyasu Ouchi, James J. Moon, Venkateshwar G. Keshamouni, Rachel L. Zemans, Vibha N. Lama, Douglas A. Arenberg, and Marc Peters-Golden
iPreP is a three-dimensional nanofibrillar cellulose hydrogel platform for long-term ex vivo preservation of human islets
Yi-Ju Chen, Taiji Yamazoe, Karla F. Leavens, Fabian L. Cardenas-Diaz, Andrei Georgescu, Dongeun Huh, Paul Gadue, and Ben Z. Stanger
NK cell defects in X-linked pigmentary reticulate disorder
Petro Starokadomskyy, Katelynn M. Wilton, Konrad Krzewski, Adam Lopez, Luis Sifuentes-Dominguez, Brittany Overlee, Qing Chen, Ann Ray, Aleksandra Gil-Krzewska, Mary Peterson, Lisa N. Kinch, Luis Rohena, Eyal Grunebaum, Andrew R. Zinn, Nick V. Grishin, Daniel D. Billadeau, and Ezra Burstein
TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy
Ali Javaheri, Geetika Bajpai, Antonino Picataggi, Smrithi Mani, Layla Foroughi, Hosannah Evie, Attila Kovacs, Carla J. Weinheimer, Krzystztof Hyrc, Qingli Xiao, Andrea Ballabio, Jin-Moo Lee, Scot J. Matkovich, Babak Razani, Joel D. Schilling, Kory J. Lavine, and Abhinav Diwan
Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes
Nahal Mansouri, Gareth R. Willis, Angeles Fernandez-Gonzalez, Monica Reis, Sina Nassiri, S. Alex Mitsialis, and Stella Kourembanas
Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer
Louise A. Koopman, Mikkel G. Terp, Gijs G. Zom, Maarten L. Janmaat, Kirstine Jacobsen, Elke Gresnigt-van den Heuvel, Marcel Brandhorst, Ulf Forssmann, Freddy de Bree, Nora Pencheva, Andreas Lingnau, Maria A. Zipeto, Paul W.H.I. Parren, Esther C.W. Breij, and Henrik J. Ditzel
Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis
V. Eric Kerchberger, Julie A. Bastarache, Ciara M. Shaver, Hiromasa Nagata, J. Brennan McNeil, Stuart R. Landstreet, Nathan D. Putz, Wen-Kuang Yu, Jordan Jesse, Nancy E. Wickersham, Tatiana N. Sidorova, David R. Janz, Chirag R. Parikh, Edward D. Siew, and Lorraine B. Ware
Effects of rosuvastatin on the immune system in healthy volunteers with normal serum cholesterol
Peer W.F. Karmaus, Min Shi, Shira Perl, Angélique Biancotto, Julián Candia, Foo Cheung, Yuri Kotliarov, Neal Young, Michael B. Fessler, and the CHI Consortium
Investigation of a dilated cardiomyopathy–associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes
Chris McDermott-Roe, Wenjian Lv, Tania Maximova, Shogo Wada, John Bukowy, Maribel Marquez, Shuping Lai, Amarda Shehu, Ivor Benjamin, Aron Geurts, and Kiran Musunuru
TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway
Shilai Li, Zhongjie Yi, Meihong Deng, Melanie J. Scott, Chenxuan Yang, Wenbo Li, Zhao Lei, Nicole M. Santerre, Patricia Loughran, and Timothy R. Billiar
Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination
Bo Sun, Hui-Hsin Chang, Ari Salinger, Beverly Tomita, Mandar Bawadekar, Caitlyn L. Holmes, Miriam A. Shelef, Eranthie Weerapana, Paul R. Thompson, and I-Cheng Ho
Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia
Alessandro Matte, Enrica Federti, Michael Winter, Annette Koerner, Anja Harmeier, Norman Mazer, Tomas Tomka, Maria Luisa Di Paolo, Luigia Defalco, Immacolata Andolfo, Elisabetta Beneduce, Achille Iolascon, Alejandra Macias-Garcia, Jane-Jane Chen, Anne Janin, Christhophe Lebouef, Franco Turrini, Carlo Brugnara, and Lucia De Franceschi
Phase 2a randomized, placebo-controlled study of anti–IL-33 in peanut allergy
Sharon Chinthrajah, Shu Cao, Cherie Liu, Shu-Chen Lyu, Sayantani B. Sindher, Andrew Long, Vanitha Sampath, Daniel Petroni, Marco Londei, and Kari C. Nadeau
Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors
Katja Pekrun, Gustavo De Alencastro, Qing-Jun Luo, Jun Liu, Youngjin Kim, Sean Nygaard, Feorillo Galivo, Feijie Zhang, Ren Song, Matthew R. Tiffany, Jianpeng Xu, Matthias Hebrok, Markus Grompe, and Mark A. Kay
Cardiac sympathectomy and spinal cord stimulation attenuate reflex-mediated norepinephrine release during ischemia preventing ventricular fibrillation
Jeffrey L. Ardell, Robert D. Foreman, J. Andrew Armour, and Kalyanam Shivkumar
C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections
Serena Bettoni, Jutamas Shaughnessy, Karolina Maziarz, David Ermert, Sunita Gulati, Bo Zheng, Matthias Mörgelin, Susanne Jacobsson, Kristian Riesbeck, Magnus Unemo, Sanjay Ram, and Anna M. Blom
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model
Zhousheng Xiao, Gwendalyn King, Salvatore Mancarella, Undral Munkhsaikhan, Li Cao, Chun Cai, and Leigh Darryl Quarles
Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis
Divya Bhatia, Kuei-Pin Chung, Kiichi Nakahira, Edwin Patino, Michelle C. Rice, Lisa K. Torres, Thangamani Muthukumar, Augustine M.K. Choi, Oleh M. Akchurin, and Mary E. Choi
Discovery of specialized NK cell populations infiltrating human melanoma metastases
Lucas Ferrari de Andrade, Yuheng Lu, Adrienne Luoma, Yoshinaga Ito, Deng Pan, Jason W. Pyrdol, Charles H. Yoon, Guo-Cheng Yuan, and Kai W. Wucherpfennig
Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC
Julia Kargl, Xiaodong Zhu, Huajia Zhang, Grace H.Y. Yang, Travis J. Friesen, Melissa Shipley, Dean Y. Maeda, John A. Zebala, Jill McKay-Fleisch, Gavin Meredith, Afshin Mashadi-Hossein, Christina Baik, Robert H. Pierce, Mary W. Redman, Jeffrey C. Thompson, Steven M. Albelda, Hamid Bolouri, and A. McGarry Houghton
Low-level Cxcr4-haploinsufficient HSC engraftment is sufficient to correct leukopenia in WHIM syndrome mice
Ji-Liang Gao, Albert Owusu-Ansah, Andrea Paun, Kimberly Beacht, Erin Yim, Marie Siwicki, Alexander Yang, Qian Liu, David H. McDermott, and Philip M. Murphy
Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming
Mattia Quattrocelli, Aaron S. Zelikovich, Zhen Jiang, Clara Bien Peek, Alexis R. Demonbreun, Nancy L. Kuntz, Grant D. Barish, Saptarsi M. Haldar, Joseph Bass, and Elizabeth M. McNally
Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis
Jasmohan S. Bajaj, Nita Salzman, Chathur Acharya, Hajime Takei, Genta Kakiyama, Andrew Fagan, Melanie B. White, Edith A. Gavis, Mary L. Holtz, Michael Hayward, Hiroshi Nittono, Phillip B. Hylemon, I. Jane Cox, Roger Williams, Simon D. Taylor-Robinson, Richard K. Sterling, Scott C. Matherly, Michael Fuchs, Hannah Lee, Puneet Puri, R. Todd Stravitz, Arun J. Sanyal, Lola Ajayi, Adrien Le Guennec, R. Andrew Atkinson, Mohammad S. Siddiqui, Velimir Luketic, William M. Pandak, Masoumeh Sikaroodi, and Patrick M. Gillevet

JCI Editor’s update: Plan S, JCI Scholars, recent reviews, and more

Posted on by Maya Hoptman

Dear Colleague,

I’d like to take this opportunity to remind you of the JCI’s longstanding commitment to making all research articles available free of charge. The ASCI adopted this model in 1996 when the journal first went online, and all of our research content, from 1924 to the present, is publicly available. As ever more journals have created open access options, both researchers and funders have become involved in the conversation about publishing models and disseminating journal content. A coalition of European funders recently proposed requirements that research articles funded by their organizations be published in open access publications (see Free access to scientific publications: contrasting the JCI approach to Plan S). While details of Plan S are still emerging, I want to reaffirm the JCI’s continued support for free access for all to scientific research, a tradition that is also carried on in JCI Insight.

I would also like to highlight the JCI Scholars program, an initiative started by the current editorial board when our tenure began in 2017. The program provides physician-scientist trainees a unique opportunity to participate in manuscript evaluation and better understand the peer review and publishing process. We’ve recently expanded the program to include medical fellows as well as MD/PhD students from Johns Hopkins and the University of Maryland, and we have 8 new trainees participating in 2019. A Viewpoint article written by JCI Scholars who recently completed the program shares insights gained during their time shadowing the Editorial Board. I hope that their perspective might be useful to other young scientists in your lab as well. Read their article, as well as others in our Viewpoint series.

Sincerely,

Rexford S. Ahima, MD, PhD
Editor, The Journal of Clinical Investigation

Features for authors

Recent Review Series

ASCI members are indicated in bold.

Biology of familial cancer predisposition syndromes

Series edited by Mary Armanios and Agata Smogorzewska

Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers
John C. Chappell, Laura Beth Payne, and W. Kimryn Rathmell

PTEN-opathies: from biological insights to evidence-based precision medicine
Lamis Yehia, Joanne Ngeow, and Charis Eng

Misactivation of Hedgehog signaling causes inherited and sporadic cancers
David R. Raleigh and Jeremy F. Reiter

Transcription factor mutations as a cause of familial myeloid neoplasms
Jane E. Churpek and Emery H. Bresnick

Recently published Reviews

Corresponding authors who are ASCI members are indicated in bold.

Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas
Estela Area-Gomez, Cristina Guardia-Laguarta, Eric A. Schon, and Serge Przedborski

Molecular imaging of fibrosis: recent advances and future directions
Sydney B. Montesi, Pauline Désogère, Bryan C. Fuchs, and Peter Caravan

Mixing old and young: enhancing rejuvenation and accelerating aging
Ashley Lau, Brian K. Kennedy, James L. Kirkland, and Stefan G. Tullius

Functional significance of the platelet immune receptors GPVI and CLEC-2
Julie Rayes, Steve P. Watson, and Bernhard Nieswandt

Selective tissue targeting of synthetic nucleic acid drugs
Punit P. Seth, Michael Tanowitz, and C. Frank Bennett

Autoimmune seizures and epilepsy
Christian Geis, Jesus Planagumà, Mar Carreño, Francesc Graus, and Josep Dalmau

Environmental exposures and mechanisms in allergy and asthma development
Liza Bronner Murrison, Eric B. Brandt, Jocelyn Biagini Myers, and Gurjit K. Khurana Hershey

Epithelial barrier repair and prevention of allergy
Elena Goleva, Evgeny Berdyshev, and Donald Y.M. Leung

Top-cited JCI research articles

Data from Scopus, February 25, 2019. Corresponding authors who are ASCI members are indicated in bold.

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression
Heng Lin, Shuang Wei, Elaine M. Hurt, Michael D. Green, Lili Zhao, Linda Vatan, Wojciech Szeliga, Ronald Herbst, Paul W. Harms, Leslie A. Fecher, Pankaj Vats, Arul M. Chinnaiyan, Christopher D. Lao, Theodore S. Lawrence, Max Wicha, Junzo Hamanishi, Masaki Mandai, Ilona Kryczek, and Weiping Zou
Times cited: 28

PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression
Haidong Tang, Yong Liang, Robert A. Anders, Janis M. Taube, Xiangyan Qiu, Aditi Mulgaonkar, Xin Liu, Susan M. Harrington, Jingya Guo, Yangchun Xin, Yahong Xiong, Kien Nham, William Silvers, Guiyang Hao, Xiankai Sun, Mingyi Chen, Raquibul Hannan, Jian Qiao, Haidong Dong, Hua Peng, and Yang-Xin Fu
Times cited: 25

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction
Eleanor M. Dunican, Brett M. Elicker, David S. Gierada, Scott K. Nagle, Mark L. Schiebler, John D. Newell, Wilfred W. Raymond, Marrah E. Lachowicz-Scroggins, Selena Di Maio, Eric A. Hoffman, Mario Castro, Sean B. Fain, Nizar N. Jarjour, Elliot Israel, Bruce D. Levy, Serpil C. Erzurum, Sally E. Wenzel, Deborah A. Meyers, Eugene R. Bleecker, Brenda R. Phillips, David T. Mauger, Erin D. Gordon, Prescott G. Woodruff, Michael C. Peters, John V. Fahy, and The National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP)
Times cited: 22

Early B cell changes predict autoimmunity following combination immune checkpoint blockade
Rituparna Das, Noffar Bar, Michelle Ferreira, Aaron M. Newman, Lin Zhang, Jithendra Kini Bailur, Antonella Bacchiocchi, Harriet Kluger, Wei Wei, Ruth Halaban, Mario Sznol, Madhav V. Dhodapkar, and Kavita M. Dhodapkar
Times cited: 19

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells
Szu-Han Huang, Yanqin Ren, Allison S. Thomas, Dora Chan, Stefanie Mueller, Adam R. Ward, Shabnum Patel, Catherine M. Bollard, Conrad Russell Cruz, Sara Karandish, Ronald Truong, Amanda B. Macedo, Alberto Bosque, Colin Kovacs, Erika Benko, Alicja Piechocka-Trocha, Hing Wong, Emily Jeng, Douglas F. Nixon, Ya-Chi Ho, Robert F. Siliciano, Bruce D. Walker, and R. Brad Jones
Times cited: 18

Hepatitis B virus–specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation
Laura Rivino, Nina Le Bert, Upkar S. Gill, Kamini Kunasegaran, Yang Cheng, Damien Z.M. Tan, Etienne Becht, Navjyot K. Hansi, Graham R. Foster, Tung-Hung Su, Tai-Chung Tseng, Seng Gee Lim, Jia-Horng Kao, Evan W. Newell, Patrick T.F. Kennedy, and Antonio Bertoletti
Times cited: 17

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Gina A. Montealegre Sanchez, Adam Reinhardt, Suzanne Ramsey, Helmut Wittkowski, Philip J. Hashkes, Yackov Berkun, Susanne Schalm, Sara Murias, Jason A. Dare, Diane Brown, Deborah L. Stone, Ling Gao, Thomas Klausmeier, Dirk Foell, Adriana A. de Jesus, Dawn C. Chapelle, Hanna Kim, Samantha Dill, Robert A. Colbert, Laura Failla, Bahar Kost, Michelle O’Brien, James C. Reynolds, Les R. Folio, Katherine R. Calvo, Scott M. Paul, Nargues Weir, Alessandra Brofferio, Ariane Soldatos, Angelique Biancotto, Edward W. Cowen, John J. Digiovanna, Massimo Gadina, Andrew J. Lipton, Colleen Hadigan, Steven M. Holland, Joseph Fontana, Ahmad S. Alawad, Rebecca J. Brown, Kristina I. Rother, Theo Heller, Kristina M. Brooks, Parag Kumar, Stephen R. Brooks, Meryl Waldman, Harsharan K. Singh, Volker Nickeleit, Maria Silk, Apurva Prakash, Jonathan M. Janes, Seza Ozen, Paul G. Wakim, Paul A. Brogan, William L. Macias, and Raphaela Goldbach-Mansky
Times cited: 15

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles
Angela Pizzolla, Thi H.O. Nguyen, Sneha Sant, Jade Jaffar, Tom Loudovaris, Stuart I. Mannering, Paul G. Thomas, Glen P. Westall, Katherine Kedzierska, and Linda M. Wakim
Times cited: 15

Insulin resistance causes inflammation in adipose tissue
Mitsugu Shimobayashi, Verena Albert, Bettina Woelnerhanssen, Irina C. Frei, Diana Weissenberger, Anne Christin Meyer-Gerspach, Nicolas Clement, Suzette Moes, Marco Colombi, Jerome A. Meier, Marta M. Swierczynska, Paul Jenö, Christoph Beglinger, Ralph Peterli, and Michael N. Hall
Times cited: 14

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
Xing Fu, Hadi Khalil, Onur Kanisicak, Justin G. Boyer, Ronald J. Vagnozzi, Bryan D. Maliken, Michelle A. Sargent, Vikram Prasad, Iñigo Valiente-Alandi, Burns C. Blaxall, and Jeffery D. Molkentin
Times cited: 13

CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis
Liang Guo, Hirokuni Akahori, Emanuel Harari, Samantha L. Smith, Rohini Polavarapu, Vinit Karmali, Fumiyuki Otsuka, Rachel L. Gannon, Ryan E. Braumann, Megan H. Dickinson, Anuj Gupta, Audrey L. Jenkins, Michael J. Lipinski, Johoon Kim, Peter Chhour, Paul S. de Vries, Hiroyuki Jinnouchi, Robert Kutys, Hiroyoshi Mori, Matthew D. Kutyna, Sho Torii, Atsushi Sakamoto, Cheol Ung Choi, Qi Cheng, Megan L. Grove, Mariem A. Sawan, Yin Zhang, Yihai Cao, Frank D. Kolodgie, David P. Cormode, Dan E. Arking, Eric Boerwinkle, Alanna C. Morrison, Jeanette Erdmann, Nona Sotoodehnia, Renu Virmani, and Aloke V. Finn
Times cited: 13

Recent articles with ASCI members as corresponding authors

Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates
Ranjit Sivanandham, Egidio Brocca-Cofano, Noah Krampe, Elizabeth Falwell, Sindhuja Murali Kilapandal Venkatraman, Ruy M. Ribeiro, Cristian Apetrei, and Ivona Pandrea

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted
Jeremy S. Tilstra, Lyndsay Avery, Ashley V. Menk, Rachael A. Gordon, Shuchi Smita, Lawrence P. Kane, Maria Chikina, Greg M. Delgoffe, and Mark J. Shlomchik

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction
Dennis M. Abraham, Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, Geoffrey S. Pitt, Svati H. Shah, Matthew J. Wolf, and Howard A. Rockman

Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis
Maria Florencia Martinez, Silvia Medrano, Evan A. Brown, Turan Tufan, Stephen Shang, Nadia Bertoncello, Omar Guessoum, Mazhar Adli, Brian C. Belyea, Maria Luisa S. Sequeira-Lopez, and R. Ariel Gomez

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease
Ta-Chiang Liu, Justin T. Kern, Kelli L. VanDussen, Shanshan Xiong, Gerard E. Kaiko, Craig B. Wilen, Michael W. Rajala, Roberta Caruso, Michael J. Holtzman, Feng Gao, Dermot P.B. McGovern, Gabriel Nunez, Richard D. Head, and Thaddeus S. Stappenbeck

SMAD4 promotes TGF-β–independent NK cell homeostasis and maturation and antitumor immunity
Youwei Wang, Jianhong Chu, Ping Yi, Wejuan Dong, Jennifer Saultz, Yufeng Wang, Hongwei Wang, Steven Scoville, Jianying Zhang, Lai-Chu Wu, Youcai Deng, Xiaoming He, Bethany Mundy-Bosse, Aharon G. Freud, Li-Shu Wang, Michael A. Caligiuri, and Jianhua Yu

Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice
Jacqueline G. Parchem, Keizo Kanasaki, Megumi Kanasaki, Hikaru Sugimoto, Liang Xie, Yuki Hamano, Soo Bong Lee, Vincent H. Gattone, Samuel Parry, Jerome F. Strauss, Vesna D. Garovic, Thomas F. McElrath, Karen H. Lu, Baha M. Sibai, Valerie S. LeBleu, Peter Carmeliet, and Raghu Kalluri

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease
Dongchang Zhao, Yeung-Hyen Kim, Seihwan Jeong, Joel K. Greenson, Mohammed S. Chaudhry, Matthias Hoepting, Erik R. Anderson, Marcel R.M. van den Brink, Jonathan U. Peled, Antonio L.C. Gomes, Ann E. Slingerland, Michael J. Donovan, Andrew C. Harris, John E. Levine, Umut Ozbek, Lora V. Hooper, Thaddeus S. Stappenbeck, Aaron Ver Heul, Ta-Chiang Liu, Pavan Reddy, and James L.M. Ferrara

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells
Aditi Shastri, Gaurav Choudhary, Margarida Teixeira, Shanisha Gordon-Mitchell, Nandini Ramachandra, Lumie Bernard, Sanchari Bhattacharyya, Robert Lopez, Kith Pradhan, Orsolya Giricz, Goutham Ravipati, Li-Fan Wong, Sally Cole, Tushar D. Bhagat, Jonathan Feld, Yosman Dhar, Matthias Bartenstein, Victor J. Thiruthuvanathan, Amittha Wickrema, B. Hilda Ye, David A. Frank, Andrea Pellagatti, Jacqueline Boultwood, Tianyuan Zhou, Youngsoo Kim, A. Robert MacLeod, P.K. Epling-Burnette, Minwei Ye, Patricia McCoon, Richard Woessner, Ulrich Steidl, Britta Will, and Amit Verma

Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis
Babita Madan, Nathan Harmston, Gahyathiri Nallan, Alex Montoya, Peter Faull, Enrico Petretto, and David M. Virshup

PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression
Shuai Dong, Bonnie K. Harrington, Eileen Y. Hu, Joseph T. Greene, Amy M. Lehman, Minh Tran, Ronni L. Wasmuth, Meixiao Long, Natarajan Muthusamy, Jennifer R. Brown, Amy J. Johnson, and John C. Byrd

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup
Stephanie A. Christenson, Maarten van den Berge, Alen Faiz, Kai Inkamp, Nirav Bhakta, Luke R. Bonser, Lorna T. Zlock, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Richard C. Boucher, Russell P. Bowler, Alejandro P. Comellas, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Pieter S. Hiemstra, Robert J. Kaner, Jerry A. Krishnanm, Fernando J. Martinez, Wanda K. O’Neal, Robert Paine III, Wim Timens, J. Michael Wells, Avrum Spira, David J. Erle, and Prescott G. Woodruff

Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
Sungro Jo, Tatiana L. Fonseca, Barbara M.L.C. Bocco, Gustavo W. Fernandes, Elizabeth A. McAninch, Anaysa P. Bolin, Rodrigo R. Da Conceição, Joao Pedro Werneck-de-Castro, Daniele L. Ignacio, Péter Egri, Dorottya Németh, Csaba Fekete,Maria Martha Bernardi, Victoria D. Leitch, Naila S. Mannan, Katharine F. Curry, Natalie C. Butterfield, J.H. Duncan Bassett, Graham R. Williams, Balázs Gereben, Miriam O. Ribeiro, and Antonio C. Bianco

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
Jun Wei, Anantha Marisetty, Brett Schrand, Konrad Gabrusiewicz, Yuuri Hashimoto, Martina Ott, Zacharia Grami, Ling-Yuan Kong, Xiaoyang Ling, Hillary Caruso, Shouhao Zhou, Y. Alan Wang, Gregory N. Fuller, Jason Huse, Eli Gilboa, Nannan Kang, Xingxu Huang, Roel Verhaak, Shulin Li, and Amy B. Heimberger

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity
Chien-Chun Steven Pai, Donald M. Simons, Xiaoqing Lu, Michael Evans, Junnian Wei, Yung-hua Wang, Mingyi Chen, John Huang, Chanhyuk Park, Anthony Chang, Jiaxi Wang, Susan Westmoreland, Christine Beam, Dave Banach, Diana Bowley, Feng Dong, Jane Seagal, Wendy Ritacco, Paul L. Richardson, Soumya Mitra, Grace Lynch, Pete Bousquet, John Mankovich, Gillian Kingsbury, and Lawrence Fong

Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
Ming Chen, Jiangwen Zhang, Alice H. Berger, Moussa S. Diolombi, Christopher Ng, Jacqueline Fung, Roderick T. Bronson, Mireia Castillo-Martin, Tin Htwe Thin, Carlos Cordon-Cardo, Robin Plevin, and Pier Paolo Pandolfi

ʟ-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
Robert A. Koeth, Betzabe Rachel Lam-Galvez, Jennifer Kirsop, Zeneng Wang, Bruce S. Levison, Xiaodong Gu, Matthew F. Copeland, David Bartlett, David B. Cody, Hong J. Dai, Miranda K. Culley, Xinmin S. Li, Xiaoming Fu, Yuping Wu, Lin Li, Joseph A. DiDonato, W.H. Wilson Tang, Jose Carlos Garcia-Garcia, and Stanley L. Hazen

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia
Toshiro Saito, Jihoon Nah, Shin-ichi Oka, Risa Mukai, Yoshiya Monden, Yasuhiro Maejima, Yoshiyuki Ikeda, Sebastiano Sciarretta, Tong Liu, Hong Li, Erdene Baljinnyam, Diego Fraidenraich, Luke Fritzky, Peiyong Zhai, Shizuko Ichinose, Mitsuaki Isobe, Chiao-Po Hsu, Mondira Kundu, and Junichi Sadoshima

Cardiac CaV1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking
Lin Yang, Alexander Katchman, Jared Kushner, Alexander Kushnir, Sergey I. Zakharov, Bi-xing Chen, Zunaira Shuja, Prakash Subramanyam, Guoxia Liu, Arianne Papa, Daniel Roybal, Geoffrey S. Pitt, Henry M. Colecraft, and Steven O. Marx

Rescue of recurrent deep intronic mutation underlying cell type–dependent quantitative NEMO deficiency
Bertrand Boisson, Yoshitaka Honda, Masahiko Ajiro, Jacinta Bustamante, Matthieu Bendavid, Andrew R. Gennery, Yuri Kawasaki, Jose Ichishima, Mitsujiro Osawa, Hiroshi Nihira, Takeshi Shiba, Takayuki Tanaka, Maya Chrabieh, Benedetta Bigio, Hong Hur, Yuval Itan, Yupu Liang, Satoshi Okada, Kazushi Izawa, Ryuta Nishikomori, Osamu Ohara, Toshio Heike, Laurent Abel, Anne Puel, Megumu K. Saito, Jean-Laurent Casanova, Masatoshi Hagiwara, and Takahiro Yasumi

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia
Hongjie Wang, Aphrodite Georgakopoulou, Nikoletta Psatha, Chang Li, Chrysi Capsali, Himanshu Bhusan Samal, Achilles Anagnostopoulos, Anja Ehrhardt, Zsuzsanna Izsvák, Thalia Papayannopoulou, Evangelia Yannaki, and André Lieber

Gene fitness landscape of group A streptococcus during necrotizing myositis
Luchang Zhu, Randall J. Olsen, Stephen B. Beres, Jesus M. Eraso, Matthew Ojeda Saavedra, Samantha L. Kubiak, Concepcion C. Cantu, Leslie Jenkins, Amelia R. L. Charbonneau, Andrew S. Waller, and James M. Musser

HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia
Alejandro A. Pezzulo, Rosarie A. Tudas, Carley G. Stewart, Luis G. Vargas Buonfiglio, Brian D. Lindsay, Peter J. Taft, Nicholas D. Gansemer, and Joseph Zabner

Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
Sahra Bodo, Cécile Campagne, Tin Htwe Thin, Daniel S. Higginson, H. Alberto Vargas, Guoqiang Hua, John D. Fuller, Ellen Ackerstaff, James Russell, Zhigang Zhang, Stefan Klingler, HyungJoon Cho, Matthew G. Kaag, Yousef Mazaheri, Andreas Rimner, Katia Manova-Todorova, Boris Epel, Joan Zatcky, Cristian R. Cleary, Shyam S. Rao, Yoshiya Yamada, Michael J. Zelefsky, Howard J. Halpern, Jason A. Koutcher, Carlos Cordon-Cardo, Carlo Greco, Adriana Haimovitz-Friedman, Evis Sala, Simon N. Powell, Richard Kolesnick, and Zvi Fuks

Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection
Wenjun Li, Jason M. Gauthier, Ryuji Higashikubo, Hsi-Min Hsiao, Satona Tanaka, Linh Vuong, Jon H. Ritter, Alice Y. Tong, Brian W. Wong, Ramsey R. Hachem, Varun Puri, Ankit Bharat, Alexander S. Krupnick, Chyi S. Hsieh, William M. Baldwin III, Francine L. Kelly, Scott M. Palmer, Andrew E. Gelman, and Daniel Kreisel

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
Sam C. Nalle, Li Zuo, Ma. Lora Drizella M. Ong, Gurminder Singh, Alicia M. Worthylake, Wangsun Choi, Mario Cabrero Manresa, Anna P. Southworth, Karen L. Edelblum, Gregory J. Baker, Nora E. Joseph, Peter A. Savage, and Jerrold R. Turner

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome
Elena Gallo MacFarlane, Sarah J. Parker, Joseph Y. Shin, Benjamin E. Kang, Shira G. Ziegler, Tyler J. Creamer, Rustam Bagirzadeh, Djahida Bedja, Yichun Chen, Juan F. Calderon, Katherine Weissler, Pamela A. Frischmeyer-Guerrerio, Mark E. Lindsay, Jennifer P. Habashi, and Harry C. Dietz

JCI Insight Editor’s update: January 2018

Posted on by Maya Hoptman

I am pleased to update you on recent JCI Insight activity. Together, our outstanding Editorial Board and distinguished team of Consulting Editors have helped JCI Insight publish excellent science across all areas of biomedicine, quickly and efficiently.

As authors, ASCI members have been a driving force behind the success of the journal since its launch in January 2016 (see below for a list of recent research articles with members as corresponding authors). I encourage you to consider submitting your research to JCI Insight. A reminder: ASCI members who are the corresponding author of a first-round submission to JCI Insight may designate up to three submissions per calendar year to be guaranteed for external peer review. For further details, visit the For Authors page.

To mark its second year of publication, JCI Insight began publishing reviews in 2017. These reviews, many of which are authored by recently elected ASCI members, cover topics in oncology, hepatology, transplantation, and other areas; they are listed at the end of this message.

By the end of last year, the journal published nearly 640 articles across the following categories.

It is gratifying to note that JCI Insight articles are being recognized in their respective fields; a sample of those that have been widely cited appears below. The volume of papers directly submitted to JCI Insight for consideration has been steadily increasing, another sign of the recognition the journal is receiving.

In addition to evaluating submissions previously considered at the JCI, JCI Insight also considers papers submitted with reviews from other top-tier journals, which we feel is important in reducing the overall burden on authors and reviewers. Read more about the process here.

As always, I look forward to seeing your research and welcome your feedback.

Howard A. Rockman, MD
Editor, JCI Insight

Recent articles with ASCI members as corresponding authors (indicated in bold)

Research
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs
Erin Janssen, Sudha Kumari, Mira Tohme, Sumana Ullas, Victor Barrera, Jeroen M.J. Tas, Marcela Castillo-Rama, Roderick T. Bronson, Shariq M. Usmani, Darrell J. Irvine, Thorsten R. Mempel, and Raif S. Geha
Research
Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair
Michael S. Hu, Graham G. Walmsley, Leandra A. Barnes, Kipp Weiskopf, Robert C. Rennert, Dominik Duscher, Michael Januszyk, Zeshaan N. Maan, Wan Xing Hong, Alexander T.M. Cheung, Tripp Leavitt, Clement D. Marshall, Ryan C. Ransom, Samir Malhotra, Alessandra L. Moore, Jayakumar Rajadas, H. Peter Lorenz, Irving L. Weissman, Geoffrey C. Gurtner, and Michael T. Longaker
Clinical Medicine
Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults
Sergei Spitsin, Pablo Tebas, Jeffrey S. Barrett, Vasiliki Pappa, Deborah Kim, Deanne Taylor, Dwight L. Evans, and Steven D. Douglas

Research
Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity
Mark Rochman, Jared Travers, J. Pablo Abonia, Julie M. Caldwell, and Marc E. Rothenberg
Research
Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1
Cuiwen He, Xuchen Hu, Rachel S. Jung, Mikael Larsson, Yiping Tu, Sandra Duarte-Vogel, Paul Kim, Norma P. Sandoval, Tara R. Price, Christopher M. Allan, Brian Raney, Haibo Jiang, André Bensadoun, Rosemary L. Walzem, Richard I. Kuo, Anne P. Beigneux, Loren G. Fong, and Stephen G. Young

Research
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment
Amar N. Mirza, Micah A. Fry, Nicole M. Urman, Scott X. Atwood, Jon Roffey, Gregory R. Ott, Bin Chen, Alex Lee, Alexander S. Brown, Sumaira Z. Aasi, Tyler Hollmig, Mark A. Ator, Bruce D. Dorsey, Bruce R. Ruggeri, Craig A. Zificsak, Marina Sirota, Jean Y. Tang, Atul Butte, Ervin Epstein, Kavita Y. Sarin, and Anthony E. Oro
Research
B cell–derived IL-4 acts on podocytes to induce proteinuria and foot process effacement
Alfred H.J. Kim, Jun-Jae Chung, Shreeram Akilesh, Ania Koziell, Sanjay Jain, Jeffrey B. Hodgin, Mark J. Miller, Thaddeus S. Stappenbeck, Jeffrey H. Miner, and Andrey S. Shaw

Technical Advance
Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics
Yichen Ding, Arash Abiri, Parinaz Abiri, Shuoran Li, Chih-Chiang Chang, Kyung In Baek, Jeffrey J. Hsu, Elias Sideris, Yilei Li, Juhyun Lee, Tatiana Segura, Thao P. Nguyen, Alexander Bui, René R. Sevag Packard, Peng Fei, and Tzung K. Hsiai
Clinical Medicine
Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients
Serpil M. Deger, Adriana M. Hung, Jorge L. Gamboa, Edward D. Siew, Charles D. Ellis, Cindy Booker, Feng Sha, Haiming Li, Aihua Bian, Thomas G. Stewart, Roy Zent, William E. Mitch, Naji N. Abumrad, and T. Alp Ikizler
Research
Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency–induced bone loss
Chike Cao, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, Amy L. McNulty, Farshid Guilak, Courtney M. Karner, Matthew J. Hilton, and Geoffrey S. Pitt

Research
β-Arrestin2 mediates progression of murine primary myelofibrosis
Lindsay A.M. Rein, James W. Wisler, Jihee Kim, Barbara Theriot, LiYin Huang, Trevor Price, Haeyoon Yang, Minyong Chen, Wei Chen, Dorothy Sipkins, Yuri Fedoriw, Julia K.L. Walker, Richard T. Premont, and Robert J. Lefkowitz
Research
Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants
Jia W. Tan, Tina Gupta, Worapaka Manosroi, Tham M. Yao, Paul N. Hopkins,
Jonathan S. Williams, Gail K. Adler, Jose R. Romero, and Gordon H. Williams

Research
Alveolar injury and regeneration following deletion of ABCA3
Tara N. Rindler, Courtney A. Stockman, Alyssa L. Filuta, Kari M. Brown, John M. Snowball, Wenjia Zhou, Ruud Veldhuizen, Erika M. Zink, Sydney E. Dautel, Geremy Clair, Charles Ansong, Yan Xu, James P. Bridges, and Jeffrey A. Whitsett
Research
Eosinophils promote inducible nitric oxide synthase–mediated lung allograft acceptance
Oscar Okwudiri Onyema, Yizhan Guo, Qing Wang, Mark H. Stoler, Christine Lau, Kang Li, Christopher Nazaroff, Xingan Wang, Wenjun Li, Daniel Kreisel, Andrew E. Gelman, James J Lee, Elizabeth A. Jacobsen, and Alexander Sasha Krupnick
Research
Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet–induced oxidative stress
Tsehay Abebe, Jana Mahadevan, Lindsey Bogachus, Stephanie Hahn, Michele Black, Elizabeth Oseid, Fumihiko Urano, Vincenzo Cirulli, and R. Paul Robertson
Research
Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms
Mary C. Drinane, Usman Yaqoob, Haibin Yu, Fanghong Luo, Thomas Greuter, Juan P. Arab, Enis Kostallari, Vikas K. Verma, Jessica Maiers, Thiago Milech De Assuncao, Michael Simons, Debabrata Mukhopadhyay, Tatiana Kisseleva, David A. Brenner, Raul Urrutia, Gwen Lomberk, Yandong Gao, Giovanni Ligresti, Daniel J. Tschumperlin, Alexander Revzin, Sheng Cao, and Vijay H. Shah

Top-cited JCI Insight research articles

Data are from Web of Science, as of January 9, 2018. Corresponding authors who are ASCI members are indicated in bold.
Research
Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype Citations: 28
Konrad Gabrusiewicz, Benjamin Rodriguez, Jun Wei, Yuuri Hashimoto, Luke M. Healy, Sourindra N. Maiti, Ginu Thomas, Shouhao Zhou, Qianghu Wang, Ahmed Elakkad, Brandon D. Liebelt, Nasser K. Yaghi, Ravesanker Ezhilarasan, Neal Huang, Jeffrey S. Weinberg, Sujit S. Prabhu, Ganesh Rao, Raymond Sawaya, Lauren A. Langford, Janet M. Bruner, Gregory N. Fuller, Amit Bar-Or, Wei Li, Rivka R. Colen, Michael A. Curran, Krishna P. Bhat, Jack P. Antel, Laurence J. Cooper, Erik P. Sulman, and Amy B. Heimberger
Research
Zika virus productively infects primary human placenta-specific macrophages Citations: 26
Kellie Ann Jurado, Michael K. Simoni, Zhonghua Tang, Ryuta Uraki, Jesse Hwang, Sarah Householder, Mingjie Wu, Brett D. Lindenbach, Vikki M. Abrahams, Seth Guller, and Erol Fikrig
Research
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis Citations: 22
Lucy V. Norling, Sarah E. Headland, Jesmond Dalli, Hildur H. Arnardottir, Oliver Haworth, Hefin R. Jones, Daniel Irimia, Charles N. Serhan, and Mauro Perretti
Clinical Medicine
Protection against Plasmodium falciparum malaria by PfSPZ Vaccine Citations: 19
Judith E. Epstein, Kristopher M. Paolino, Thomas L. Richie, Martha Sedegah, Alexandra Singer, Adam J. Ruben, Sumana Chakravarty, April Stafford, Richard C. Ruck, Abraham G. Eappen, Tao Li, Peter F. Billingsley, Anita Manoj, Joana C. Silva, Kara Moser, Robin Nielsen, Donna Tosh, Susan Cicatelli, Harini Ganeshan, Jessica Case, Debbie Padilla, Silas Davidson, Lindsey Garver, Elizabeth Saverino, Tooba Murshedkar, Anusha Gunasekera, Patrick S. Twomey, Sharina Reyes, James E. Moon, Eric R. James, Natasha KC, Minglin Li, Esteban Abot, Arnel Belmonte, Kevin Hauns, Maria Belmonte, Jun Huang, Carlos Vasquez, Shon Remich, Mary Carrington, Yonas Abebe, Amy Tillman, Bradley Hickey, Jason Regules, Eileen Villasante, B. Kim Lee Sim, and Stephen L. Hoffman
Clinical Medicine
Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata Citations: 19
Milène Kennedy Crispin, Justin M. Ko, Brittany G. Craiglow, Shufeng Li, Gautam Shankar, Jennifer R. Urban, James C. Chen, Jane E. Cerise, Ali Jabbari, Mårten C.G. Winge, M. Peter Marinkovich, Angela M. Christiano, Anthony E. Oro, and Brett A. King
Clinical Medicine
Institutional implementation of clinical tumor profiling on an unselected cancer population Citations: 18
Lynette M. Sholl, Khanh Do, Priyanka Shivdasani, Ethan Cerami, Adrian M. Dubuc, Frank C. Kuo, Elizabeth P. Garcia, Yonghui Jia, Phani Davineni, Ryan P. Abo, Trevor J. Pugh, Paul van Hummelen, Aaron R. Thorner, Matthew Ducar, Alice H. Berger, Mizuki Nishino, Katherine A. Janeway, Alanna Church, Marian Harris, Lauren L. Ritterhouse, Joshua D. Campbell, Vanesa Rojas-Rudilla, Azra H. Ligon, Shakti Ramkissoon, James M. Cleary, Ursula Matulonis, Geoffrey R. Oxnard, Richard Chao, Vanessa Tassell, James Christensen, William C. Hahn, Philip W. Kantoff, David J. Kwiatkowski, Bruce E. Johnson, Matthew Meyerson, Levi A. Garraway, Geoffrey I. Shapiro, Barrett J. Rollins, Neal I. Lindeman, and Laura E. MacConaill

JCI Insight Reviews

Corresponding authors who are ASCI members are indicated in bold.
Microbiota, cirrhosis, and the emerging oral-gut-liver axis
Chathur Acharya, Sinem Esra Sahingur, and Jasmohan S. Bajaj
Emerging therapies for acute myeloid leukemia: translating biology into the clinic
Simon Kavanagh, Tracy Murphy, Arjun Law, Dana Yehudai, Jenny M. Ho, Steve Chan, and Aaron D. Schimmer
Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis
Thomas Greuter, Harmeet Malhi, Gregory J. Gores, and Vijay H. Shah
Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
Elia J. Duh, Jennifer K. Sun, and Alan W. Stitt
Immunity against fungi
Michail S. Lionakis, Iliyan D. Iliev, and Tobias M. Hohl
Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop
Vibha N. Lama, John A. Belperio, Jason D. Christie, Souheil El-Chemaly, Michael C. Fishbein, Andrew E. Gelman, Wayne W. Hancock, Shaf Keshavjee, Daniel Kreisel, Victor E. Laubach, Mark R. Looney, John F. McDyer, Thalachallour Mohanakumar, Rebecca A. Shilling, Angela Panoskaltsis-Mortari, David S. Wilkes, Jerry P. Eu, and Mark R. Nicolls
Discerning functional hierarchies of microRNAs in pulmonary hypertension
Vinny Negi and Stephen Y. Chan
Setting the target for pemphigus vulgaris therapy
Christoph T. Ellebrecht and Aimee S. Payne

Call for nominations, 2018 Stanley J. Korsmeyer Award

Posted on by Maya Hoptman

Nominations for the ASCI’s 2018 Stanley J. Korsmeyer Award are now open. This coming year represents a milestone for the Award — 20 years of recognizing the outstanding achievements of ASCI member physician-scientists. The recognition, first called the ASCI Award, was renamed in 2006 in honor of Dr. Korsmeyer, the first recipient of the Award in 1998, who passed away in 2005. The Korsmeyer Award recognizes individuals for their advancement of knowledge in a specific field and mentoring of future generations of life science researchers. Information on all past honorees is available here.

Nominees for the Stanley J. Korsmeyer Award must be ASCI members who are 55 years of age or younger as of January 1, 2018. They shall have made significant contributions to biomedical science and shall have adhered to the principles of scientific excellence that the ASCI exemplifies. The nominee should have a record that reflects high standards of intellectual integrity, a deep and abiding respect for the community of biomedical scientists, and a strong commitment to mentoring the next generation of physician-scientists. Prior nominees may be re-nominated. However, current ASCI Council members and prior Award recipients may not be nominated.

Nominations consist of:

  • a summary of the nominee’s accomplishments (in plain text, not to exceed 250 words),
  • a brief NIH biosketch (as a PDF),
  • a full curriculum vitae, including all publications and invited lectures (as a PDF),
  • and a trainee table (preferred as a PDF).

Nominations must be submitted by ASCI members through their online accounts.

The deadline for nominations is October 13, 2017, at 11:59 PM EDT.

Gordon F. Tomaselli elected as next JCI Editor in Chief

Posted on by Maya Hoptman

Dr. Tomaselli

The ASCI is pleased to announce the election of Gordon F. Tomaselli, MD, as Editor of the Journal of Clinical Investigation (ASCI profile). Dr. Tomaselli’s tenure as Editor begins July 1 and extends to June 30, 2022. Dr. Tomaselli is Michel Mirowski, MD, Professor of Cardiology; Professor of Medicine; Professor of Cellular and Molecular Medicine; and Chief, Division of Cardiology at the Johns Hopkins University. He is an expert in the fields of sudden cardiac death and arrhythmias, with research focused on ion channel structure, function, and remodeling.

Dr. Tomaselli is the 24th editor of the JCI, and his election represents the first time Johns Hopkins will host the journal’s Editorial Board, which since its founding in 1924 has had 5-year tenures at academic medical centers. Serving alongside Dr. Tomaselli as Deputy Editors will be Rexford S. Ahima, MD, PhD, Bloomberg Distinguished Professor of Diabetes, whose research focuses on central and peripheral regulation of energy homeostasis, and glucose and lipid metabolism; and Arturo Casadevall, MD, PhD, Bloomberg Distinguished Professor of Molecular Microbiology & Immunology and Infectious Diseases, who studies fungal and bacterial pathogenesis and basic immunology of antibody structure-function.

The distinguished Editorial Board of Johns Hopkins faculty members serving as JCI Associate Editors will include Richard F. Ambinder, MD, PhD (oncology), Mark E. Anderson, MD, PhD (cardiology), Mary Y. Armanios, MD (oncology, aging), William R. Bishai, MD, PhD (infectious disease), Robert A. Brodsky, MD (hematology), Peter A. Calabresi, MD (neuroinflammation), Thomas L. Clemens, PhD (bone biology), Franco R. D’Alessio, MD (pulmonology), Ted M. Dawson, MD, PhD (neuroscience), Angelo M. DeMarzo, MD, PhD (oncology), Stephen Desiderio, MD, PhD (immunology, cell biology), Harry C. Dietz III, MD (genetics), Mark Donowitz, MD (gastroenterology), Andrew P. Feinberg, MD, MPH (genetics), Sharon Gerecht, PhD (vascular biology, tissue engineering), Paul M. Hassoun, MD (pulmonology), Elizabeth M. Jaffe, MD (oncology, immunology), David A. Kass, MD (cardiology), Kieren A. Marr, MD (infectious disease, transplantation), Timothy H. Moran, PhD (metabolism and psychiatric disorders), William Nelson, MD, PhD (oncology), Brian O’Rourke, PhD (cardiology), Ben Ho Park, MD, PhD (oncology), Jonathan D. Powell, MD, PhD (immunology), Thomas C. Quinn, MD (infectious disease), Hamid Rabb, MD (nephrology), Stuart C. Ray, MD (infectious disease), Antony Rosen, MD (rheumatology), Jeffrey D. Rothstein, MD, PhD (neuroscience), Scheherazade Sadegh-Nasseri, PhD (immunology), Jonathan Schneck, MD, PhD (immunology), Gregg L. Semenza, MD, PhD (cell biology, signaling), Robert F. Siliciano, MD, PhD (infectious disease, HIV), Charlotte Sumner, MD (muscle biology), David L. Thomas, MD, MPH (infectious disease), and Robert G. Weiss, MD (cardiology, energetics).

Applications for JCI Editor were evaluated by the JCI Editor Selection Committee: Vivian G. Cheung (Chair), Benjamin L. Ebert, Jonathan A. Epstein, Helen H. Hobbs, Brendan Lee, Andrew R. Marks, Charles L. Sawyers, Arthur Weiss, Stephen J. Weiss, and Leonard I. Zon. The ASCI Council approved the recommended candidate, whose selection was submitted for a vote by the Active members of the Society. The vote approving the selection of Dr. Tomaselli was confirmed May 17, 2017.