The ASCI’s 2018 Young Physician-Scientist Awards

The ASCI is pleased to recognize the 35 recipients of its 2018 Young Physician-Scientist Awards. The Awardees presented their work at the ASCI’s Food & Science Evening, on April 21, 2018, as part of the AAP/ASCI/APSA Joint Meeting, April 20-22, 2018.

Awardee Institution Abstract title
Ana Paula Abreu, MD, PhD Brigham and Women’s Hospital, Harvard Medical School MKRN3, a new player in the reproductive axis
Raag D. Airan, MD, PhD Stanford University Spatiotemporally precise and versatile noninvasive neuromodulation via focused ultrasonic drug uncaging
Francis J. Alenghat, MD, PhD University of Chicago Skap2 regulates atherosclerosis through macrophage polarization and efferocytosis
Vivek K. Arora, MD, PhD Washington University School of Medicine Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation
Megan T. Baldridge, MD, PhD Washington University School of Medicine Transferable microbiota factor stimulates resistance to norovirus infection in immunodeficient mice
Scott W. Canna, MD University of Pittsburgh/Children’s Hospital of Pittsburgh Dysregulation of interleukin-18 diagnostically distinguishes and pathogenically promotes macrophage activation syndrome
Brian Curran Capell, MD, PhD Perelman School of Medicine, University of Pennsylvania KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
Kevin J. Cheung, MD Fred Hutchinson Cancer Research Center Tumor cell clustering promotes breast cancer metastasis by increasing apoptosis resistance and cell proliferation
Silvia S. Chiang, MD Alpert Medical School of Brown University/ Hasbro Children’s Hospital/ Center for International Health Research Barriers to the diagnosis of childhood tuberculosis: a qualitative study
Janet Chou, MD Boston Children’s Hospital Leucine-rich repeat–containing 8A (LRRC8A) is essential for T cell activation by non-hematopoietic antigen-presenting cells
Louis Jared Cohen, MD, MS Icahn School of Medicine at Mount Sinai Bacterial modulation of human glycans in inflammatory bowel disease
Kimberley Jane Evason, MD, PhD Huntsman Cancer Institute and University of Utah Serotonin in zebrafish liver development and tumorigenesis
Jennifer E. Flythe, MD, MPH University of North Carolina-Chapel Hill Failed target weight achievement associates with short-term hospital encounters
Robert David Guzy, MD, PhD University of Chicago Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis through inhibition of fibroblast collagen production
Andrew M. Intlekofer, MD, PhD Memorial Sloan Kettering Cancer Center Acquired clinical resistance to IDH inhibition through in trans IDH2 mutations
Prasanna Jagannathan, MD Stanford University Impact of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy on risk of malaria in early childhood
Benjamin Levi, MD University of Michigan Tuning inflammation to improve musculoskeletal wound healing through modification of monocyte/macrophage Tgfb1
Piro Lito, MD, PhD Memorial Sloan Kettering Cancer Center Modeling the evolution of resistance to ERK signaling inhibitors at the single cell level
Steven E. Mansoor, MD, PhD Knight Cardiovascular Institute, Oregon Health and Science University Mechanisms of P2X receptor activation, desensitization, and antagonism­­­­
Jonathan J. Miner, MD, PhD Washington University Mouse models of Zika virus pathogenesis
Zaman Mirzadeh, MD, PhD Barrow Neurological Institute Perineuronal net formation in the hypothalamic arcuate nucleus-median eminence corresponds with the end of the critical period for AgRP/NPY neuron maturation
Chiadi Ericson Ndumele, MD, PhD Johns Hopkins University The association of longitudinal changes in metabolic syndrome with incident heart failure: the Atherosclerosis Risk in Communities (ARIC) study
Esther A. Obeng, MD, PhD St. Jude Children’s Research Hospital The nonsense-mediated decay pathway is a therapeutic vulnerability in myelodysplastic syndromes
Michael Joseph Ombrello, MD National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH IL1RN variation is associated with systemic juvenile idiopathic arthritis and predicts non-response to anakinra treatment
Cevher Ozcan, MD University of Chicago Mitochondrial mechanism of atrial fibrillation and novel therapies for primary prevention of the disease process
James R. Priest, MD Stanford University School of Medicine Rare inherited variants confer substantial risk for congenital heart disease in a large British cohort
Jarrad M. Scarlett, MD, PhD University of Washington Diabetes remission induced by the central action of fibroblast growth factor 1
Chetan Shenoy, MBBS University of Minnesota Long-term outcomes after detection of left ventricular thrombus by late gadolinium enhancement cardiovascular magnetic resonance imaging
Neeraj K. Surana, MD, PhD Boston Children’s Hospital Moving beyond microbiome-wide associations to causal microbe identification
David B. Sykes, MD, PhD Massachusetts General Hospital DHODH inhibition as differentiation therapy for acute myeloid leukemia: understanding the metabolic therapeutic window
Viviany R. Taqueti, MD, MPH Brigham and Women’s Hospital Coronary microvascular dysfunction is a better discriminator of cardiovascular risk than body mass index in obese patients
Sarah Kathleen Tasian, MD Children’s Hospital of Philadelphia and University of Pennsylvania Essential JAK, SRC, and PI3K signaling pathways regulate cell survival in human Ph-like acute lymphoblastic leukemia
Kirk J. Wangensteen, MD, PhD University of Pennsylvania Perelman School of Medicine Novel combination therapy for hepatocellular carcinoma identified by genetic screening
Melissa Y. Yeung, MD Harvard Medical School / Brigham and Women’s Hospital Identifying key regulators of B cell–mediated transplant tolerance
Lilei Zhang, MD, PhD Baylor College of Medicine KLF15 regulates the circadian susceptibility to ischemia reperfusion injury in the heart

Best Poster Award recipients

Each year, the ASCI recognizes three presenters with $1,000 Best Poster Awards. The 2018 Best Poster Award recipients are, from left, Drs. Guzy, Mansoor, and Canna.