The ASCI’s 2019 Young Physician-Scientist Awards

The ASCI is pleased to recognize the 35 recipients of its 2019 Young Physician-Scientist Awards. The Awardees will present their work at the ASCI’s Food & Science Evening, on April 6, 2019, as part of the AAP/ASCI/APSA Joint Meeting, April 5-7, 2019.

Recipient Institution Abstract title
Kristopher R. Bosse, MD University of Pennsylvania The antibody-drug conjugate D3-GPC2-PBD potently eradicates neuroblastoma patient-derived xenografts
Lindsay C. Burrage, MD, PhD Baylor College of Medicine Biallelic variants in TONSL cause SPONASTRIME dysplasia and varied skeletal dysplasia phenotypes
James E. Cassat, MD, PhD Vanderbilt University Medical Center Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions
Tara I. Chang, MD, MS Stanford University School of Medicine Systolic and diastolic blood pressure and the risks of myocardial infarction, stroke and death: a reanalysis of ALLHAT
Scott M. Damrauer, MD University of Pennsylvania Perelman School of Medicine Genetics of peripheral artery disease in the Million Veteran Program
Maneesh Dave, MBBS, MPH Case Western Reserve University and University Hospitals Intestinal stem cell niche-derived 3D organoids recapitulate features of Crohn’s disease
Matthew J. Feinstein, MD, MSc Northwestern University Feinberg School of Medicine Phenotypes and characteristics of incident heart failure in human immunodeficiency virus
Marcus D. Goncalves, MD, PhD Weill Cornell College of Medicine High-fructose corn syrup enhances intestinal tumor growth
Gentzon Hall, MD, PhD Duke University The LMX1βR246Q mutation induces podocyte injury through dysregulation of cholesterol transport gene expression
Arnold Han, MD, PhD Columbia University Tracking individual T cell clones in response to immunotherapy
Brent A. Hanks, MD, PhD Duke University A novel inflammasome-Wnt signaling axis drives adaptive resistance to anti-PD-1 antibody immunotherapy in cancer
Cheng-Ying Ho, MD, PhD University of Maryland The role of keratinocyte-derived SIRT1 and BDNF in alleviating diabetic neuropathy
Ali Javaheri, MD, PhD Washington University School of Medicine Macrophage transcription factor EB attenuates myocardial dysfunction and inflammation after ischemia-reperfusion injury
Douglas B. Johnson, MD, MSCI Vanderbilt University Medical Center Clinical and molecular profiling of immune checkpoint inhibitor (ICI) induced neurotoxicity
Judith R. Kelsen, MD, MS The Children’s Hospital of Philadelphia A predictive signature of immune-mediated monogenic defects in children with very early-onset inflammatory bowel disease
Rami Khoriaty, MD University of Michigan SEC23A and SEC23B have overlapping functions in mice
Corrine R. Kliment, MD, PhD University of Pittsburgh Mitochondrial adenine nucleotide translocase influences ciliary function and airway homeostasis
Jonathan A. Kropski, MD Vanderbilt University Medical Center Single-cell genomic analysis of pulmonary fibrosis phenotypes
Alisa B. Lee-Sherick, MD University of Colorado School of Medicine MerTK is a potential immunotherapeutic target in acute leukemia
Stephanie Lovinsky-Desir, MD, MS Columbia University The role of tidal volume and respiratory rate in the relationship between pollutant exposure and airway inflammation
Jonathan M. Nizar, MD University of Iowa Dietary potassium regulates Thiazide diuretic sensitivity and is necessary for obesity-induced Thiazide sensitivity
Michael L. O’Byrne, MD, MSCE The Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania Practice variation in transcatheter and operative closure of patent ductus arteriosus in United States neonatal intensive care units
Ross A. Okimoto, MD University of California, San Francisco The CIC-DUX4 fusion oncoprotein drives metastasis and tumor growth via distinct downstream regulatory programs and therapeutic targets in sarcoma
Mitesh S. Patel, MD, MBA, MS University of Pennsylvania Effect of an automated patient dashboard using active choice and peer comparison performance feedback to physicians on statin prescribing: the PRESCRIBE Cluster Randomized Clinical Trial
Jennifer E. Posey, MD, PhD Baylor College of Medicine Rare variant family-based genomics reveals impact of population substructure on rate of multiple molecular diagnoses
Kurt Prins, MD, PhD University of Minnesota Increased protein O-GlcNAcylation is associated with right ventricular dysfunction in pulmonary arterial hypertension
Sunad Rangarajan, MD University of Colorado Anschutz Medical Campus Mitochondrial uncoupling protein-2 and fibroblast senescence in age-related lung fibrosis
Jeffery D. Roizen, MD, PhD The Children’s Hospital of Philadelphia Differential prevalence of CYP2R1 mutations across populations reveals an adaptive mechanism and pathway selection for maintaining serum 25-hydroxyvitamin D
Jason J. Rose, MD, MBA University of Pittsburgh School of Medicine Recombinant neuroglobin reverses the molecular mitochondrial effects of CO poisoning through CO scavenging
Benjamin D. Singer, MD Northwestern University Feinberg School of Medicine The epigenetic regulator Uhrf1 is essential for regulatory T cell development and maintenance
Benjamin H. Singer, MD, PhD University of Michigan Sepsis drives both pro-inflammatory and anti-inflammatory transcriptional responses in the human brain
Elizabeth A. Stewart, MD St. Jude Children’s Research Hospital Preclinical modeling of targeted therapeutics in pediatric solid tumors
Junko Takeshita, MD, PhD, MSCE University of Pennsylvania Perelman School of Medicine Racial disparities in use of ambulatory and emergency care among children with atopic dermatitis in the Pediatric Eczema Elective Registry
Zuzana Tothova, MD, PhD Dana-Farber Cancer Institute STAG2 mutations in leukemia alter cohesin complex function, DNA damage repair, and splicing
David Wu, MD, PhD University of Chicago Single cell metabolism reveals that a RhoA-mediated glycolytic burst drives endothelial cell contractions