Recipient of the 2025 Louis W. Sullivan, MD, Award: Consuelo H. Wilkins, MD, MSCI

Consuelo H. Wilkins, MD, MSCI
Dr. Wilkins

The American Society for Clinical Investigation is pleased to recognize Consuelo H. Wilkins, MD, MSCI, as recipient of the 2025 ASCI/Louis W. Sullivan, MD, Award, for her groundbreaking contributions in community engagement and health equity, including large-cohort imaging studies suggesting that amyloid-directed therapies are less likely to benefit Black, Hispanic, and Asian individuals with memory loss. Dr. Wilkins receives an honorarium of $10,000 and delivers a scientific talk at the 2026 AAP/ASCI/APSA Joint Meeting.

As part of her work in Alzheimer’s disease, Dr. Wilkins used amyloid PET imaging on large cohorts of individuals with memory loss and found that the odds of having a positive scan were lower among Black, Latino, and Asian populations. The results indicate that fewer people in these groups will be eligible for recently approved anti-amyloid therapies compared with White individuals.

Dr. Wilkins’ research has transformed efforts to increase clinical research engagement and improve health outcomes for all. Her team established the Community Engagement Studio (CES), a formalized approach to incorporating the voice of community stakeholders at all stages of clinical research — a model adopted by numerous studies and many academic health centers in the US, Canada, and the United Kingdom. Dr. Wilkins has developed and validated instruments to measure trust in research and standards for compensating community partners. She has created frameworks that serve as a blueprint for academic medical centers to personalize care based on the needs of their populations.

Dr. Sullivan’s transformational work has been an inspiration for me. My work spans clinical research, policy-focused systems change, and advocacy for health equity – all of which are areas where Dr. Sullivan is an icon. In my current roles, I have the unique opportunity to leverage my research to build new programs and develop institutional policies that ensure everyone has an opportunity to achieve optimal health.

– Dr. Wilkins

Dr. Jeffrey R. Balser, President and CEO, Vanderbilt University Medical Center (VUMC) and Dean, Vanderbilt University School of Medicine, nominated Dr. Wilkins for this recognition. He wrote, “Dr. Wilkins embodies the spirit of the Award through her groundbreaking work. Her research, particularly in Alzheimer’s disease, has reshaped the field. She leads initiatives that measurably enhance participation from all communities and promote institutional change.”

Dr. Wilkins received her MD from Howard University College of Medicine, completed a residency at Duke University Medical Center and fellowship in geriatric medicine at Barnes-Jewish Hospital/Washington University School of Medicine; and received her MSCI from Washington University School of Medicine. She is currently Senior Vice President and Senior Associate Dean for Community Health and Engagement, Mildred Thornton Stahlman Chair in Rural Health, and Professor of Medicine, VUMC; and Associate Director, Vanderbilt Institute for Clinical and Translational Research. She was elected to the National Academy of Medicine in 2020 and to the ASCI in 2022.

The 2025 Harrington Prize for Innovation in Medicine: Owen N. Witte, MD

The twelfth annual Harrington Prize for Innovation in Medicine has been awarded to Owen N. Witte, MD, Distinguished University Professor and President’s Chair in Developmental Immunology, David Geffen School of Medicine, University of California, Los Angeles. The award recognizes his foundational discoveries of targeted therapies that have transformed modern cancer treatment.

The Harrington Prize for Innovation in Medicine, established in 2014 by the Harrington Discovery Institute at University Hospitals and the American Society for Clinical Investigation (ASCI), honors physician-scientists who have moved science forward with achievements notable for innovation, creativity and potential for clinical application.

Dr. Witte is internationally known for his contributions to the understanding of human leukemias and immune disorders. His work revealed the critical role of enzymes called tyrosine kinases in human disease.

Dr. Witte discovered one of the first tyrosine kinases, the ABL oncoprotein, showing that its activity is responsible for causing chronic myeloid leukemia (CML)—a cancer of white blood cells. He predicted that drugs that inhibit the tyrosine kinase would have therapeutic benefit. Based on Dr. Witte’s work, the drug imatinib, an inhibitor of tyrosine kinase ABL, was developed as frontline therapy. Imatinib increases the 8-year survival rate for CML from 6% to 87%.

Dr. Witte subsequently discovered Bruton’s tyrosine kinase (BTK). He provided evidence that BTK’s tyrosine kinase activity was important for both normal immune function (loss of BTK led to immunodeficiency disease) and white blood cell cancers—ultimately spurring the development of the BTK inhibitor drug ibrutinib, now used to treat several types of lymphomas and leukemias.

“It is a great honor to present Dr. Witte with the Harrington Prize for Innovation in Medicine. His transformative contributions to cancer research have not only reshaped our understanding of leukemia, lymphoma, and epithelial cancers but have also revolutionized targeted therapies, directly impacting countless lives. His seminal contributions to the development of ABL and BTK inhibitors exemplifies the scientific creativity and impact this award stands for,” said Anna Greka, MD, PhD, Professor of Medicine at Harvard Medical School, Physician at Mass General Brigham, Core Institute Member of the Broad Institute of MIT and Harvard, and 2024-2025 ASCI President.

“Dr. Witte’s remarkable work serves as a powerful illustration of how basic discovery can inform the development of life-saving therapies. His groundbreaking work has bridged the gap between the laboratory bench and the clinical bedside, extending human life,” said Jonathan S. Stamler, President & Co-Founder, Harrington Discovery Institute, Robert S. and Sylvia K. Reitman Family Foundation Chair of Cardiovascular Innovation, Distinguished University Professor, and Professor of Medicine and of Biochemistry at University Hospitals and Case Western Reserve University.

A committee composed of members of the ASCI Council and the Harrington Discovery Institute Scientific Advisory Board reviewed nominations from leading academic medical centers from six countries before selecting the 2025 Harrington Prize recipient.

In addition to receiving the Prize’s $20,000 honorarium, Dr. Witte will deliver the Harrington Prize Lecture at the 2025 AAP/ASCI/APSA Joint Meeting on April 25-27, and he will be a featured speaker at the 2025 Harrington Scientific Symposium May 21-22 and is invited to publish an essay in the Journal of Clinical Investigation.