| Benjamin D. Humphreys | 2023-2024 | Super chickens, givers, and collective intelligence: the importance of collaboration, teamwork, and mentorship in science |
| Sohail F. Tavazoie | 2022-2023 | From Avicenna to ASCI: embracing the challenges and opportunities of biomedical research |
| Hossein Ardehali | 2021-2022 | My journey to ASCI: why ASCI is so important to me |
| Lorraine B. Ware | 2020-2021 | Physician-scientists in the pandemic era: tidal wave or rising tide? |
| W. Kimryn Rathmell | 2019-2020 | Disruptions in the realm of medical science |
| Kieren A. Marr | 2018-2019 | The ownership paradox: nurturing continuity and change for the future ASCI |
| Benjamin L. Ebert | 2017-2018 | Generations of physician-scientists |
| Vivian G. Cheung | 2016-2017 | Vitalizing physician-scientists: it’s time to overcome our imagination fatigue |
| Levi A. Garraway | 2015-2016 | Believe the miracles: of biomedical science and human suffering |
| Mukesh K. Jain | 2014-2015 | Advancing the mission |
| Peter Tontonoz | 2013-2014 | Leading by example: pastors, mentors, physician-scientists, and the ASCI |
| William C. Hahn | 2012-2013 | The perfect storm: challenges and opportunities for translational medicine |
| Elizabeth McNally | 2011-2012 | Advocacy: yes we can |
| Paul S. Mischel | 2010-2011 | Lost — and found — in translation |
| Jonathan Epstein | 2009-2010 | Lessons of our fathers |
| Nancy Andrews | 2008-2009 | Can we keep the “academic” in academic medicine? |
| Charles L. Sawyers | 2007-2008 | Translational research: are we on the right track? |
| Barbara L. Weber | 2006-2007 | In the palace of the Sultan |
| Eric R. Fearon | 2005-2006 | Not available |
| Leonard I. Zon | 2004-2005 | 2005 ASCI Presidential Address |
| Kenneth Kaushansky | 2003-2004 | Mentoring and teaching clinical investigation |
| Chi V. Dang | 2002-2003 | Celebrating the physician-scientist |
| David Ginsburg | 2001-2002 | The history and evolution of the ASCI: déjà vu all over again |
| Gary A. Koretzky | 2000-2001 | The future of the ASCI: a lesson from the 2000 presidential election |
| Jeffrey M. Leiden | 1999-2000 | From genes to screens: crossing the digital-medical divide |
| Ajit P. Varki | 1998-1999 | Executive summary of the Nerflex Commission Report |
| Timothy J. Ley | 1997-1998 | 1998 ASCI Presidential Address |
| Judith L. Swain | 1995-1996 | Is there room left for academics in academic medicine? |
| Richard D. Klausner | 1994-1995 | Values and value: the survival of biomedical research |
| Jay A. Berzofsky | 1993-1994 | Cross-fertilization among fields: a seminal event in the progress of biomedical research |
| Bruce F. Scharschmidt | 1992-1993 | Nurturing creativity: Young Turks and young minds |
| Edward Benz | 1991-1992 | Presidential address |
| William J. Koopman | 1990-1991 | In search of Mr. Wizard |
| Stuart H. Orkin | 1989-1990 | Preparing for the next generation |
| C. Ronald Kahn | 1988-1989 | Perverted priorities: the physician/scientist as spokesman and salesman for biomedical research |
| Robert J. Lefkowitz | 1987-1988 | The spirit of science |
| Thomas P. Stossel | 1986-1987 | Brave new medicine |
| Joseph L. Goldstein | 1985-1986 | On the origin and prevention of PAIDS (Paralyzed Academic Investigator’s Disease Syndrome) |
| Robert M. Glickman | 1984-1985 | The future of the physician scientist |
| William N. Kelley | 1983-1984 | Clinical investigation and the clinical investigator: the past, present, and future |
| Louis M. Sherwood | 1982-1983 | Sustaining the spirit of inquiry: the key role of the department chairman |
| Philip W. Majerus | 1981-1982 | Fraud in medical research |
| William E. Paul | 1980-1981 | Clinical investigation — on the threshold of a golden era? |
| Jesse Roth | 1979-1980 | Sing a new song |
| Kenneth L. Melmon | 1978-1979 | A society without an obvious future: can elitism help? |
| Jean D. Wilson | 1977-1978 | Peer review and publication |
| John S. Fordtran | 1976-1977 | An ASCI tradition |
| Laurence E. Earley | 1975-1976 | The health of clinical investigation beyond Atlantic City |
| Eugene Braunwald | 1974-1975 | Can medical schools remain the optimal site for the conduct of clinical investigation? |
| Edward C. Franklin | 1973-1974 | The Individual, Science, and Society |
| Neal S. Bricker | 1972-1973 | The Time for Reflection: a Luxury of the Past |
| Paul A. Marks | 1971-1972 | Health systems research in the mainstream of academic medicine |
| Halsted R. Holman | 1970-1971 | Sounds from a different drum |
| Lloyd H. Smith Jr. | 1969-1970 | Biomedical Research and National Policy |
| Arnold S. Relman | 1968-1969 | Academic Medicine and the Public |
| Robert A. Good | 1967-1968 | Keystones |
| Grant W. Liddle | 1966-1967 | The Mores of Clinical Investigation |
| Donald W. Seldin | 1965-1966 | Some Reflections on the Role of Basic Research and Service in Clinical Departments |
| Alexander Leaf | 1964-1965 | Clinical Investigation and Social Responsibility |
| Irving M. London | 1963-1964 | The Impact of the Revolution in Biology on Clinical Investigation |
| John P. Merrill | 1962-1963 | Presidential address |
| Henry G. Kunkel | 1961-1962 | The training of the clinical investigator |
| Clement A. Finch | 1960-1961 | The shape of clinical investigation |
| Robert W. Berliner | 1959-1960 | The problems of the Society, 1960 |
| John A. Luetscher, Jr. | 1958-1959 | Observations on growth and development of clinical investigation |
| Richard V. Ebert | 1957-1958 | Clinical investigation and medical education |
| Stanley E. Bradley | 1956-1957 | The tradition of scientific critique |
| A. McGehee Harvey | 1955-1956 | The individual in medical research and the role of the university center in his training |
| Robert H. Williams | 1954-1955 | Activities of the american society for clinical investigation |
| Carl V. Moore | 1953-1954 | Presidential address |
| Eugene A. Stead, Jr. | 1952-1953 | Presidential address |
| W. Barry Wood, Jr. | 1951-1952 | The “logarithmic phase” of medical progress |
| Eugene B. Ferris, Jr. | 1950-1951 | An inquiry into the meaning of clinical investigation |
| Thomas Hale Ham | 1949-1950 | The man and quality in clinical investigation |
| Wesley W. Spink | 1948-1949 | Clinical research as a career |
| J. S. L. Browne | 1947-1948 | Medicine – its mental climate |
| Thomas Francis, Jr. | 1945-1946 | Biological beachheads |
| Fuller Albright | 1944-1945 | Some of the “do’s” and “do-not’s” in clinical investigation |
| William Dock | 1941-1942 | Presidential address |
| Isaac Starr | 1939-1940 | Functions and dysfunctions of learned societies |
| T.R. Harrison | 1938-1939 | Presidential address |
| C.C. Bass | 1925-1926 | Malaria: some interesting observations relative to malaria that have been made in the treatment of general paralysis by inoculation with malaria plasmodia |