The ASCI’s 2019 Young Physician-Scientist Awards
The ASCI is pleased to recognize the 35 recipients of its 2019 Young Physician-Scientist Awards. The Awardees will present their work at the ASCI’s Food & Science Evening, on April 6, 2019, as part of the AAP/ASCI/APSA Joint Meeting, April 5-7, 2019.
| Recipient | Institution | Abstract title |
|---|---|---|
| Kristopher R. Bosse, MD | University of Pennsylvania | The antibody-drug conjugate D3-GPC2-PBD potently eradicates neuroblastoma patient-derived xenografts |
| Lindsay C. Burrage, MD, PhD | Baylor College of Medicine | Biallelic variants in TONSL cause SPONASTRIME dysplasia and varied skeletal dysplasia phenotypes |
| James E. Cassat, MD, PhD | Vanderbilt University Medical Center | Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions |
| Tara I. Chang, MD, MS | Stanford University School of Medicine | Systolic and diastolic blood pressure and the risks of myocardial infarction, stroke and death: a reanalysis of ALLHAT |
| Scott M. Damrauer, MD | University of Pennsylvania Perelman School of Medicine | Genetics of peripheral artery disease in the Million Veteran Program |
| Maneesh Dave, MBBS, MPH | Case Western Reserve University and University Hospitals | Intestinal stem cell niche-derived 3D organoids recapitulate features of Crohn’s disease |
| Matthew J. Feinstein, MD, MSc | Northwestern University Feinberg School of Medicine | Phenotypes and characteristics of incident heart failure in human immunodeficiency virus |
| Marcus D. Goncalves, MD, PhD | Weill Cornell College of Medicine | High-fructose corn syrup enhances intestinal tumor growth |
| Gentzon Hall, MD, PhD | Duke University | The LMX1βR246Q mutation induces podocyte injury through dysregulation of cholesterol transport gene expression |
| Arnold Han, MD, PhD | Columbia University | Tracking individual T cell clones in response to immunotherapy |
| Brent A. Hanks, MD, PhD | Duke University | A novel inflammasome-Wnt signaling axis drives adaptive resistance to anti-PD-1 antibody immunotherapy in cancer |
| Cheng-Ying Ho, MD, PhD | University of Maryland | The role of keratinocyte-derived SIRT1 and BDNF in alleviating diabetic neuropathy |
| Ali Javaheri, MD, PhD | Washington University School of Medicine | Macrophage transcription factor EB attenuates myocardial dysfunction and inflammation after ischemia-reperfusion injury |
| Douglas B. Johnson, MD, MSCI | Vanderbilt University Medical Center | Clinical and molecular profiling of immune checkpoint inhibitor (ICI) induced neurotoxicity |
| Judith R. Kelsen, MD, MS | The Children’s Hospital of Philadelphia | A predictive signature of immune-mediated monogenic defects in children with very early-onset inflammatory bowel disease |
| Rami Khoriaty, MD | University of Michigan | SEC23A and SEC23B have overlapping functions in mice |
| Corrine R. Kliment, MD, PhD | University of Pittsburgh | Mitochondrial adenine nucleotide translocase influences ciliary function and airway homeostasis |
| Jonathan A. Kropski, MD | Vanderbilt University Medical Center | Single-cell genomic analysis of pulmonary fibrosis phenotypes |
| Alisa B. Lee-Sherick, MD | University of Colorado School of Medicine | MerTK is a potential immunotherapeutic target in acute leukemia |
| Stephanie Lovinsky-Desir, MD, MS | Columbia University | The role of tidal volume and respiratory rate in the relationship between pollutant exposure and airway inflammation |
| Jonathan M. Nizar, MD | University of Iowa | Dietary potassium regulates Thiazide diuretic sensitivity and is necessary for obesity-induced Thiazide sensitivity |
| Michael L. O’Byrne, MD, MSCE | The Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania | Practice variation in transcatheter and operative closure of patent ductus arteriosus in United States neonatal intensive care units |
| Ross A. Okimoto, MD | University of California, San Francisco | The CIC-DUX4 fusion oncoprotein drives metastasis and tumor growth via distinct downstream regulatory programs and therapeutic targets in sarcoma |
| Mitesh S. Patel, MD, MBA, MS | University of Pennsylvania | Effect of an automated patient dashboard using active choice and peer comparison performance feedback to physicians on statin prescribing: the PRESCRIBE Cluster Randomized Clinical Trial |
| Jennifer E. Posey, MD, PhD | Baylor College of Medicine | Rare variant family-based genomics reveals impact of population substructure on rate of multiple molecular diagnoses |
| Kurt Prins, MD, PhD | University of Minnesota | Increased protein O-GlcNAcylation is associated with right ventricular dysfunction in pulmonary arterial hypertension |
| Sunad Rangarajan, MD | University of Colorado Anschutz Medical Campus | Mitochondrial uncoupling protein-2 and fibroblast senescence in age-related lung fibrosis |
| Jeffery D. Roizen, MD, PhD | The Children’s Hospital of Philadelphia | Differential prevalence of CYP2R1 mutations across populations reveals an adaptive mechanism and pathway selection for maintaining serum 25-hydroxyvitamin D |
| Jason J. Rose, MD, MBA | University of Pittsburgh School of Medicine | Recombinant neuroglobin reverses the molecular mitochondrial effects of CO poisoning through CO scavenging |
| Benjamin D. Singer, MD | Northwestern University Feinberg School of Medicine | The epigenetic regulator Uhrf1 is essential for regulatory T cell development and maintenance |
| Benjamin H. Singer, MD, PhD | University of Michigan | Sepsis drives both pro-inflammatory and anti-inflammatory transcriptional responses in the human brain |
| Elizabeth A. Stewart, MD | St. Jude Children’s Research Hospital | Preclinical modeling of targeted therapeutics in pediatric solid tumors |
| Junko Takeshita, MD, PhD, MSCE | University of Pennsylvania Perelman School of Medicine | Racial disparities in use of ambulatory and emergency care among children with atopic dermatitis in the Pediatric Eczema Elective Registry |
| Zuzana Tothova, MD, PhD | Dana-Farber Cancer Institute | STAG2 mutations in leukemia alter cohesin complex function, DNA damage repair, and splicing |
| David Wu, MD, PhD | University of Chicago | Single cell metabolism reveals that a RhoA-mediated glycolytic burst drives endothelial cell contractions |